Inmaculada Cerrada Serra
Imelda Ontoria Oviedo
Ana María Cervera Zamora
Pilar Sepúlveda Sanchís
Nahuel Aquiles Garcia
Delia Castellano Izquierdo
Rubén Carrero García
Laura Pardo García
Marina Piquer Gil
Hernan González-King Garibotti
CIPF-IISLAFE Associated Research Unit of Cardiovascular Repair
Cardiovascular diseases are a major health problem in developed countries. Among them, heart failure has limited treatments and cell therapy has emerged as an alternative tool to conventional treatments. The Mixt Unit for Cardiovascular Repair is a collaborative program between IISLAFE and Principe Felipe Research Centre. The group aims to develop a basic research with a significant translational component, that will contribute to the development of new treatments for ischemic diseases. The study of cellular mechanisms triggered by adult stem cells and factors that influence cardiomyocyte cell death in apoptotic and inflammatory environments will allow the identification of molecular targets for the development of new drugs. The scientific activity of the group focuses on the use of adult stem cells in preclinical models of cardiac repair, the study exosomes as mediators of cellular communication, the use of iPSC as tools for cardiotoxicity testing heart as well as the evaluation of new materials for cardiac repair.
A comparison of electrospun polymers reveals poly(3-hydroxybutyrate) fiber as a superior scaffold for cardiac repair.
Castellano D, Blanes M, Marco B, Cerrada I, Ruiz-Saurí A, Pelacho B, Araña M, Montero JA, Cambra V, Prosper F, Sepúlveda P
Stem cells and development , 2014 Jul 1, vol. 23, pag. 1479-90
Hypoxia-inducible factor 1 alpha contributes to cardiac healing in mesenchymal stem cells-mediated cardiac repair.
Cerrada I, Ruiz-Saurí A, Carrero R, Trigueros C, Dorronsoro A, Sanchez-Puelles JM, Diez-Juan A, Montero JA, Sepúlveda P
Stem cells and development , 2013 Feb 1, vol. 22, pag. 501-11
Allogenicity of human cardiac stem/progenitor cells orchestrated by programmed death ligand 1.
Lauden L, Boukouaci W, Borlado LR, López IP, Sepúlveda P, Tamouza R, Charron D, Al-Daccak R
Circulation research , 2013 Feb 1, vol. 112, pag. 451-64
IL1ß induces mesenchymal stem cells migration and leucocyte chemotaxis through NF-?B.
Carrero R, Cerrada I, Lledó E, Dopazo J, García-García F, Rubio MP, Trigueros C, Dorronsoro A, Ruiz-Sauri A, Montero JA, Sepúlveda P
Stem cell reviews , 2012 Sep, vol. 8, pag. 905-16, Impact Factor: 4.523
Mesenchymal stem cells provide better results than hematopoietic precursors for the treatment of myocardial infarction.
Armiñán A, Gandía C, García-Verdugo JM, Lledó E, Trigueros C, Ruiz-Saurí A, Miñana MD, Solves P, Payá R, Montero JA, Sepúlveda P
Journal of the American College of Cardiology , 2010 May 18, vol. 55, pag. 2244-53, Impact Factor: 14.293