CIPF-FISABIO Joint Research Unit of Biomedical Imaging
The Joint Research Unit CIPF/FISABIO is mainly focused on the study of Brain Connectivity. The brain is a complex network of interconnected regions both structurally and functionally. The functional communications between brain regions play a key role in cognitive processes. Mental activities involve activation of neural networks in the brain areas involved creating various circuits in order to perform complex cognitive functions. The analysis of brain connectivity allows understanding the organization of the human brain, how distinct neural networks perform various tasks or how activation patterns are altered in pathological situations.
The Joint Research Unit develops methods to detect and quantify these connectivity types and their relation with brain function and combines different mathematical techniques to analyze images. It then interprets and integrates biological and medical knowledge to obtain models that explain and predict brain function in normal and pathological conditions. The objectives are: to advance in the understanding of the mechanisms involved in the neurological impairment in different pathological situations, to better understand its causes, to develop early diagnostic procedures of cognitive impairment and to evaluate the usefulness of therapeutic procedures to reverse or prevent it.
Reversible Axonal Dystrophy by Calcium Modulation in Frataxin-Deficient Sensory Neurons of YG8R Mice
Belén Mollá, Diana C. Muñoz-Lasso, Fátima Riveiro, Arantxa Bolinches-Amorós, Federico V. Pallardó, Angel Fernandez-Vilata8, María de la Iglesia-Vaya8, Francesc Palau1 and Pilar Gonzalez-Cabo
Frontiers in molecular neuroscience , 2017 Aug 30,
Clinical decision support systems in child and adolescent psychiatry: a systematic review.
Koposov R, Fossum S, Frodl T, Nytrø Ø, Leventhal B, Sourander A, Quaglini S, Molteni M, de la Iglesia Vayá M, Prokosch HU, Barbarini N, Milham MP, Castellanos FX, Skokauskas N
European child & adolescent psychiatry , 2017 Apr 28,
BIMCV: Synergy between Peta Bytes of data in population medical imaging, computer aided diagnosis and AVR
Maria de la Iglesia Vayá, JoseMariaSalinas, GonzaloM.Rojas, JuanCarlosPerezCortes, RafaelLlobet, Miguel Angel Cazorla, Jacobo Martínez, Luis Martí Bonmatí, Ignacio Blanquer, Manuel Regaña, Jose Miguel Puig Saques
Digital Healthcare Empowering Europeans , 2015 Jan 01, vol. 210, pag. 987-89
Abnormal synchrony and effective connectivity in patients with schizophrenia and auditory hallucinations.
de la Iglesia-Vaya M, Escartí MJ, Molina-Mateo J, Martí-Bonmatí L, Gadea M, Castellanos FX, Aguilar García-Iturrospe EJ, Robles M, Biswal BB, Sanjuan J
NeuroImage. Clinical , 2014, vol. 6, pag. 171-9
Increased amygdala and parahippocampal gyrus activation in schizophrenic patients with auditory hallucinations: an fMRI study using independent component analysis.
Escartí MJ, de la Iglesia-Vayá M, Martí-Bonmatí L, Robles M, Carbonell J, Lull JJ, García-Martí G, Manjón JV, Aguilar EJ, Aleman A, Sanjuán J
Schizophrenia research , 2010 Mar, vol. 117, pag. 31-41, Impact Factor: 4.374
An overlay of components that represent limbic and subcortical networks (CE09, HE11, HE06, NHE13) from controls (green), patients with hallucinations (pink) and patients without chronic hallucinations (yellow). The mesh represents an overlap between the study groups. Spatial maps associated with these networks are presented in sagittal (B), coronal (C) and axial (A) views. White lines are the reference of the top image slices.