CIPF-UPV Joint Research Unit of Diseases Mechanisms and Nanomedicine
The original research interest of our group is to understand the basic mechanisms of the interplay of cell signaling and planar cell polarity during development. Our main experimental model is the developing limb of the fruitfly Drosophila melanogaster.
In addition, we are using our expertise in Genetics and Developmental Biology, and the experimental toolkit of Drosophila, to generate disease models to study the pathophysiology of neuromuscular diseases, with a particular interest in the Charcot-Marie-Tooth neuropathy.
In collaboration with other groups within the Programme of Genetic and Rare Diseases at the CIPF, we are contributing to the development of the Cellular Reprogramming Platform. This technological service aims to generate induced pluripotent stem (iPS) cells from a variety of sources as a tool for basic and translational research.
A Drosophila model of GDAP1 function reveals the involvement of insulin signalling in the mitochondria-dependent neuromuscular degeneration.
López Del Amo V, Palomino-Schätzlein M, Seco-Cervera M, García-Giménez JL, Pallardó FV, Pineda-Lucena A, Galindo MI
Biochimica et biophysica acta , 2017 Mar, vol. 1863, pag. 801-809
Mitochondrial defects and neuromuscular degeneration caused by altered expression of Drosophila Gdap1: implications for the Charcot-Marie-Tooth neuropathy.
López Del Amo V, Seco-Cervera M, García-Giménez JL, Whitworth AJ, Pallardó FV, Galindo MI
Human molecular genetics , 2015 Jan 1, vol. 24, pag. 21-36
Planar cell polarity controls directional Notch signaling in the Drosophila leg.
Capilla A, Johnson R, Daniels M, Benavente M, Bray SJ, Galindo MI
Development (Cambridge, England) , 2012 Jul, vol. 139, pag. 2584-93, Impact Factor: 6.208
Control of Distal-less expression in the Drosophila appendages by functional 3' enhancers.
Galindo MI, Fernández-Garza D, Phillips R, Couso JP
Developmental biology , 2011 May 15, vol. 353, pag. 396-410, Impact Factor: 4.069
Missense mutations in the SH3TC2 protein causing Charcot-Marie-Tooth disease type 4C affect its localization in the plasma membrane and endocytic pathway.
Lupo V, Galindo MI, Martínez-Rubio D, Sevilla T, Vílchez JJ, Palau F, Espinós C
Human molecular genetics , 2009 Dec 1, vol. 18, pag. 4603-14