Félix Sancenón Galarza
María Dolores Marcos Martínez
José Ramón Murguía Ibáñez
Andrea Bernardos Bau
Elena Aznar Gimeno
María del Carmen Martínez Bisbal
Alba García Fernández
Juan Francisco Blández Barradas
Paula Díez Sánchez
Alejandra Estepa Fernández
Araceli Lérida Viso
Elena Lucena Sánchez
Gema Vivo Llorca
Blanca Escriche Navarro
Beatriz Lozano Torres
Vicente Candela Noguera
Andrea Escudero Noguera
Angela Morella Aucejo
CIPF-UPV Joint Research Unit of Diseases Mechanisms and Nanomedicine
The principal objective of our unit is mainly devoted to the development and application of new nanomedicines and probes for diagnosis, prognosis, and therapy in various diseases. At this respect, our principal research lines are:
Development of nanomaterials functionalized with "molecular gates" for controlled drug release protocols: Our goal is to develop nanosystems based on mesoporous silica nanoparticles, equipped with molecular gates that are able to retain a cargo within the pore system and deliver it by applying a specific stimulus (redox changes, pH changes, enzymes, light, magnetic fields, etc). The development of these therapeutic nanosystems allows achieve a controlled release of the drug in the area of action, thus reducing undesired side effects. Another line of research in the field of controlled release involves the development of nanoparticles capable of communicating between them or with cells by exchanging chemical messengers, capable of cooperative work (nanorobots), or with the ability to move independently.
Development of nanomaterials functionalized with "molecular gates" for the detection of biomolecules: This research line is based on the development of mesoporous silica nanoparticles equipped with molecular gates for the specific detection of certain substances and biological markers (proteins, DNA, etc.). These nanodevices are designed in such a way that in the presence of the substance of interest, a recognition reaction occurs at the molecular level, allowing the displacement of the molecular gate and thus the release of the cargo within the pore system that generates an easily measurable colorimetric or fluorometric signal.
Development of molecular probes: Another of the group research line is based on the development of chemical molecular probes for the detection of molecules or biomarkers of interest both in vitro and in vivo using colorimetric or fluorometric methods.
Enzyme-Powered Gated Mesoporous Silica Nanomotors for On-Command Intracellular Payload Delivery.
Llopis-Lorente A, García-Fernández A, Murillo-Cremaes N, Hortelão AC, Patiño T, Villalonga R, Sancenón F, Martínez-Máñez R, Sánchez S.
ACS Nano. 2019, 13, 12171-12183.
An Interactive Model of Communication between Abiotic Nanodevices and Microorganisms.
De Luis B, Llopis-Lorente A, Rincón P, Gadea J, Sancenón F, Aznar E, Villalonga R, Murguía JR, Martínze-Máñez R.
Angew. Chem. Int. Ed. Engl. 2019, 58, 14986-14990.
The chemistry of senescence.
Lozano-Torres B, Estepa-Fernández A, Rovira M, Orzáez M, Serrano M, Martínez-Máñez R, Sancenón F.
Nat. Rev. Chem. 2019, 3, 426–441.
An OFF-ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo.
Lozano-Torres B, Galiana I, Rovira M, Garrido E, Chaib S, Bernardos A, Muñoz-Espín D, Serrano M, Martínez-Máñez R, Sancenón F.
J. Am. Chem. Soc. 2017, 139, 8808-8811.
Interactive models of communication at the nanoscale using nanoparticles that talk to one another.
Llopis-Lorente A, Diez P, Sánchez A, Marcos MD, Sancenón F, Martínez-Ruíz P, Villalonga R, Martínez-Máñez R.
Nat. Commun. 2017, 8, 15511-15518.