CIPF-UV Joint Research Unit of Organic Molecules

Medicinal Chemistry is the subject that refers to the discovery, identification and preparation of new biologically active chemical entities at the molecular level. Its ultimate goal is to achieve safer and more efficient drugs for the treatment of diverse pathologies. The main aim of the research that we develop in the Organic Molecules laboratory is the synthesis of new compounds with potential biological activity. Therefore, the fundamental research level is made up of the development of new synthetic methodologies leading to those molecules in a simple and selective manner. In this sense, our research group is interested in the synthesis of organofluorine compounds, since it is well known that the introduction of fluorine atoms into organic molecules often improves their chemical and pharmacological properties. Additionally, we are also interested in the design and synthesis of new peptidomimetics and other small molecules capable of activating or inhibiting specific therapeutic targets.

Selected Publications

From 2000 to mid-2010: a fruitful decade for the synthesis of pyrazoles.
Fustero S, Sánchez-Roselló M, Barrio P, Simón-Fuentes A
Chemical reviews , 2011 Nov 9, vol. 111, pag. 6984-7034, Impact Factor: 40.197
Asymmetric synthesis of quaternary a-amino acid derivatives and their fluorinated analogues.
Fustero S, Sánchez-Roselló M, Báez C, Del Pozo C, García Ruano JL, Alemán J, Marzo L, Parra A
Amino acids , 2011 Aug, vol. 41, pag. 559-73, Impact Factor: 3.248
New cathepsin inhibitors to explore the fluorophilic properties of the S2 pocket of cathepsin B: design, synthesis, and biological evaluation.
Fustero S, Rodrigo V, Sánchez-Roselló M, del Pozo C, Timoneda J, Frizler M, Sisay MT, Bajorath J, Calle LP, Cañada FJ, Jiménez-Barbero J, Gütschow M
Chemistry (Weinheim an der Bergstrasse, Germany) , 2011 May 2, vol. 17, pag. 5256-60, Impact Factor: 5.925
Diastereoselective intramolecular additions of allyl- and propargylsilanes to iminium ions: synthesis of cyclic and bicyclic quaternary amino acids.
Fustero S, Mateu N, Simón-Fuentes A, Aceña JL
Organic letters , 2010 Jul 2, vol. 12, pag. 3014-7, Impact Factor: 5.25
FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status.
Moreno-Manzano V, Rodríguez-Jiménez FJ, Aceña-Bonilla JL, Fustero-Lardíes S, Erceg S, Dopazo J, Montaner D, Stojkovic M, Sánchez-Puelles JM
The Journal of biological chemistry , 2010 Jan 8, vol. 285, pag. 1333-42, Impact Factor: 5.328