CIPF-UV Joint Research Unit of Cytomics
Cytomics is the discipline that studies heterogeneous cellular systems at the individual cell level, based upon the methodologies of flow cytometry and high content image cytometry. Cytomics, or Systems Cytometry, is oriented to the knowledge of the functionality and architecture of the individual cells and their components, allowing also the generation of highly purified populations of biological cells or particles.
The CIPF-UVEG Joint Research Unit Cytomics continues the activities of the former CIPF-UVEG Joint Research Unit Laboratory of Cytomics which operated continuously from 2005 to 2015 and allowed the creation of the current Service of Cytomics, developing successfully in these years various research projects funded by European agencies and national and pharmaceutical companies. This synergy made possible to recruit expert personnel and advanced technologies in flow cytometry, cell separation and high content analysis, which arenow applied to the own research lines of the Mixed Unit, mainly in in vitro studies of prediction of toxic risk of chemical compounds. The Joint Unit also develops collaborations with research groups in CIPF, Incliva, La Fe Health Research Institute and other research centers and hospitals of the Valencian Community, as well as with Spanish and European research centers.
The Joint Unit carries out an important task of training in Cytometry, through the organization of national and international face-to-face and online courses.
Mesenchymal stromal cells enhance the engraftment of hematopoietic stem cells in an autologous mouse transplantation model.
Fernández-García M, Yañez RM, Sánchez-Domínguez R, Hernando-Rodriguez M, Peces-Barba M, Herrera G, O'Connor JE, Segovia JC, Bueren JA, Lamana ML
Stem cell research & therapy , 2015 Sep 7, vol. 6, pag. 165
Real-time cytometric assay of nitric oxide and superoxide interaction in peripheral blood monocytes: A no-wash, no-lyse kinetic method.
Balaguer S, Diaz L, Gomes A, Herrera G, O'Connor JE, Urios A, Felipo V, Montoliu C
Cytometry. Part B, Clinical cytometry , 2015 Mar 11,
Systems Biology and immune aging.
O'Connor JE, Herrera G, Martínez-Romero A, de Oyanguren FS, Díaz L, Gomes A, Balaguer S, Callaghan RC
Immunology letters , 2014 Nov, vol. 162, pag. 334-45
Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation.
Pinto S, Martínez-Romero A, O'Connor JE, Gil-Benso R, San-Miguel T, Terrádez L, Monteagudo C, Callaghan RC
BMC cancer , 2014 Feb 22, vol. 14, pag. 118
Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Tolosa L, Pinto S, Donato MT, Lahoz A, Castell JV, O'Connor JE, Gómez-Lechón MJ
Toxicological sciences : an official journal of the Society of Toxicology , 2012 May, vol. 127, pag. 187-98