Jose Manuel Saborit Torres
Andrea Cabrera Pastor
Gergana Ivaylova Mincheva
Juan Jose Gallego Roig
Paula Izquierdo Altarejos
Teresa Rubio Martínez-Abarca
Mar Martinez Garcia
M Carmen Castro Quero
Yaiza Maria Arenas Ortiz
The Laboratory of Neurobiology performs basic and translational research on the mechanisms, diagnosis and treatment of neurologic (cognitive, motor, in sleep and circadian rhythms) impairment in different pathological situations.
Using animal models we study the molecular mechanisms responsible for the neurological alterations in patients with hepatic encephalopathy (HE). Once identified the molecular alteration, we try to restore normal cerebral and neurological function through pharmacological treatments. These studies allow us to 1) prevent death induced by acute ammonia intoxication; 2) prevent or delay death in rats with acute liver failure; 3) restore learning ability and, 4) reverse hypokinesia in rats with chronic HE.
In parallel studies we assess the neurologic and cerebral alterations in patients with liver cirrhosis and minimal HE (MHE) and underlying mechanisms and look for new diagnostic procedures. We have identified 3-nitrotyrosine as the first good indicator for early MHE diagnosis. This will allow generalization of MHE diagnosis and treatment.
We also study the effects on brain development of environmental and food contaminants, (methylmercury, PCBs, pesticides). We found that ingestion of these contaminants in food by female rats leads to impaired cognitive function and altered motor activity and coordination of their pups. We are studying the underlying mechanisms.
Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy.
Dadsetan S, Balzano T, Forteza J, Cabrera-Pastor A, Taoro-Gonzalez L, Hernandez-Rabaza V, Gil-Perotín S, Cubas-Núñez L, García-Verdugo JM, Agusti A, Llansola M, Felipo V
Frontiers in molecular neuroscience , 2016, vol. 9, pag. 106
Reduced white matter microstructural integrity correlates with cognitive deficits in minimal hepatic encephalopathy.
Montoliu C, Urios A, Forn C, García-Panach J, Avila C, Gimenez-Garzó C, Wassel A, Serra MA, Giner-Durán R, Gonzalez O, Aliaga R, Belloch V, Felipo V
Gut , 2014 Jun, vol. 63, pag. 1028-30
Hepatic encephalopathy: effects of liver failure on brain function.
Nature reviews. Neuroscience , 2013 Dec, vol. 14, pag. 851-8
Patients with minimal hepatic encephalopathy show impaired mismatch negativity correlating with reduced performance in attention tests.
Felipo V, Ordoño JF, Urios A, El Mlili N, Giménez-Garzó C, Aguado C, González-Lopez O, Giner-Duran R, Serra MA, Wassel A, Rodrigo JM, Salazar J, Montoliu C
Hepatology (Baltimore, Md.) , 2012 Feb, vol. 55, pag. 530-9, Impact Factor: 12.003
Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy.
Rodrigo R, Cauli O, Gomez-Pinedo U, Agusti A, Hernandez-Rabaza V, Garcia-Verdugo JM, Felipo V
Gastroenterology , 2010 Aug, vol. 139, pag. 675-84, Impact Factor: 12.032