Pathophysiology and Therapy for Vision Disorders
The group of Pathophysiology and Therapies for Vision Disorders employs different approaches to clarify the molecular and cellular mechanisms involved in inherited retinal diseases like retinitis pigmentosa (RP). This rare disease is the main genetic cause of blindness in the developed world. We are also interested in the study of common eye disorders.
RP, like a most rare diseases, is highly heterogeneous in both clinical and genetic features. The genetic defect is responsible for the death of photoreceptors and pigment epithelium and the progressive loss of vision. However, upregulation of inflammatory mediators such as tumour necrosis factor alpha (TNFα) as well as oxidative stress, would exacerbate the neurodegenerative process.
Our final purpose is translating our knowledge from the basic sciences into the development of new treatments for patients. We focus on searching new pharmacological therapies to reduce deleterious effects of the chronic inflammation and oxidative stress present in these diseases.
We assess anti-inflammatory and antioxidant therapies in cell models, retinal explant and murine models. Besides, we develop study with RP patients to slow down the vision loss. These pharmacological approaches are mutation-independent therapies.
HIF-1a stabilization reduces retinal degeneration in a mouse model of retinitis pigmentosa.
Olivares-González L, Martínez-Fernández de la Cámara C, Hervás D, Millán JM, Rodrigo R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology , 2018 May, vol. 32, pag. 2438-2451
cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants.
Olivares-González L, Martínez-Fernández de la Cámara C, Hervás D, Marín MP, Lahoz A, Millán JM, Rodrigo R
PloS one , 2016 Nov 18, vol. 11, pag. e0166717
Adalimumab Reduces Photoreceptor Cell Death in A Mouse Model of Retinal Degeneration.
Martínez-Fernández de la Cámara C, Hernández-Pinto AM, Olivares-González L, Cuevas-Martín C, Sánchez-Aragó M, Hervás D, Salom D, Cuezva JM, de la Rosa EJ, Millán JM, Rodrigo R
Scientific reports , 2015 Jul 14, vol. 5, pag. 11764
Infliximab reduces Zaprinast-induced retinal degeneration in cultures of porcine retina.
Martínez-Fernández de la Cámara C, Olivares-González L, Hervás D, Salom D, Millán JM, Rodrigo R
Journal of neuroinflammation , 2014 Oct 10, vol. 11, pag. 172
Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa.
Martínez-Fernández de la Cámara C, Salom D, Sequedo MD, Hervás D, Marín-Lambíes C, Aller E, Jaijo T, Díaz-Llopis M, Millán JM, Rodrigo R
PloS one , 2013 Sep 12, vol. 8, pag. e74223