Molecular and Celular Pathology of Alcohol
Molecular bases of the neurotoxicity and the neurological alterations associated with alcohol consumption.
We are interested in the molecular and cellular actions of ethanol in the adult and developing brain. Prenatal alcohol exposure is a leading preventable cause of birth defects, mental retardation and neurodevelopmental disorders (FASD) including the foetal alcohol syndrome (FAS). The new pattern of binge-alcohol drinking during adolescence not only induces the neurotoxicity associated with behavioural and cognitive deficits, but also increases the vulnerability to alcohol dependence. We use neural cells in primary culture and animal models which mimic the alterations observed in alcohol-related pathologies, we attempt to: i) study the differential molecular mechanisms of the neurotoxicity of ethanol in the developing and in the adult brain, ii) elucidate the bases of the vulnerability of the developing neural cells to the action of ethanol, iii) assess the activation of the innate immune system in the brain damage and behavioral dysfunction induced by alcohol abuse, iv) investigate new biological markers that could detect neuroinflammation and prevent further brain damage and cognitive dysfunctions. We hope that our research will contribute to the understanding of ethanol-related brain injury, and will provide clues for developing potential strategies with the aim of preventing, curtailing or even restoring ethanol-induced brain damage.
Gender differences in the inflammatory cytokine and chemokine profiles induced by binge ethanol drinking in adolescence.
Pascual M, Montesinos J, Marcos M, Torres JL, Costa-Alba P, García-García F, Laso FJ, Guerri C
Addiction biology , 2017 Nov, vol. 22, pag. 1829-1841
TLR4 response mediates ethanol-induced neurodevelopment alterations in a model of fetal alcohol spectrum disorders.
Pascual M, Montesinos J, Montagud-Romero S, Forteza J, Rodríguez-Arias M, Miñarro J, Guerri C
Journal of neuroinflammation , 2017 Jul 24, vol. 14, pag. 145
Involvement of TLR4 in the long-term epigenetic changes, rewarding and anxiety effects induced by intermittent ethanol treatment in adolescence.
Montesinos J, Pascual M, Rodríguez-Arias M, Miñarro J, Guerri C
Brain, behavior, and immunity , 2016 Mar, vol. 53, pag. 159-71
TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain.
Pla A, Pascual M, Renau-Piqueras J, Guerri C
Cell death & disease , 2014 Feb 20, vol. 5, pag. e1066
Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage.
Alfonso-Loeches S, Pascual-Lucas M, Blanco AM, Sanchez-Vera I, Guerri C
The Journal of neuroscience : the official journal of the Society for Neuroscience , 2010 Jun 16, vol. 30, pag. 8285-95, Impact Factor: 7.271