TEAM LEADER

   
   
María Jesus Vicent Docón
TEL: +34 963289681 Ext. 2307
FAX: +34 963289701

RESEARCH TEAM
Scientific Collaborator
María García Flores


Colaboradora Investigadora
Maria Medel Gonzalez


Researcher
Ana Armiñan de Benito

Inmaculada Conejos Sánchez


Post-doctoral Researcher
Zoraida Andreu Martinez

Alessio Malfanti

Katia Maso


Pre-Doctoral Researcher
Sonia Vicente-Ruiz Salvador

Oleksandr Zagorodko

Irene Dolz Perez

Fernanda Rodriguez Otormin

Paula Soriano Teruel

Tetiana Melnyk


Personal Investigador
Antoni Serrano Marti


Project Manager
Stuart Atkinson


Laboratory technician
Esther Masia Sanchis

David Charbonnier

María Helena Ferrandis Jiménez

Polymer Therapeutics


Polymer Therapeutics could be considered the first polymeric nanomedicines. Clinical proof of concept for polymer conjugates has already been achieved, mainly as an anticancer therapy. However, many challenges and opportunities still lie ahead, providing scope to further develop this technology platform. Delivery of new anticancer agents focusing on novel molecular targets and their combination, development of both new and exciting polymeric materials with defined architectures and the treatment of diseases other than cancer are the most exciting and promising areas, and are therefore the chosen research lines in the Polymer Therapeutics Laboratory.

In this context, our research activity is focused on the design of second generation polymer conjugates, novel nanomedicines with application in cancer and tissue regeneration as therapeutics, as well as molecular diagnostic tools. The development of novel biodegradable polymeric carriers, the use of combination therapy or the design of nanoconjugates directed at novel molecular targets, including novel treatments for neurodegenerative disorders (Alzheimer's Disease and Spinal Cord Injury) are some of the approaches we are following in order to achieve highly specific and effective nanopharmaceutics.

Our polymeric systems are mainly based on L-glutamic acid and are designed to allow the study of the influence of the spatial conformation on the intracellular trafficking of bioactive agents, allowing for the exploration of a broader range of therapeutic applications. Quantitative tools for the study of cell and in vivo fate of our nanopharmaceutics are also being implemented. Additionally, polymer multivalency allows the use of combination therapy and even the presence of targeting residues (antibodies or peptides) markedly enhancing, therefore, the therapeutic value of these hybrid nanoconstructs.

Selected Publications


Characterization of triple-negative breast cancer preclinical models provides functional evidence of metastatic progression.
Arroyo-Crespo JJ, Armiñán A, Charbonnier D, Deladriere C, Palomino-Schätzlein M, Lamas-Domingo R, Forteza J, Pineda-Lucena A, Vicent MJ
International journal of cancer , 2019 Mar 12,
Metabolomics facilitates the discrimination of the specific anti-cancer effects of free- and polymer-conjugated doxorubicin in breast cancer models.
Armiñán A, Palomino-Schätzlein M, Deladriere C, Arroyo-Crespo JJ, Vicente-Ruiz S, Vicent MJ, Pineda-Lucena A
Biomaterials , 2018 Apr, vol. 162, pag. 144-153
Anticancer Activity Driven by Drug Linker Modification in a Polyglutamic Acid-Based Combination-Drug Conjugate
Arroyo-Crespo, J.J., Deladriere, C., Nebot, V.J., Charbonnier, D., Masiá, E., Paul, A., James, C., Armiñán, A., and Vicent, M.J.
Advanced Functional Materials , 2018 , vol. 28(22), pag. 1800931
HIF-1a inhibition by diethylstilbestrol and its polyacetal conjugate in hypoxic prostate tumour cells: insights from NMR metabolomics.
Armiñán A, Mendes L, Carrola J, Movellan J, Vicent MJ, Duarte IF
Journal of drug targeting , 2017 Nov - Dec, vol. 25, pag. 845-855
Capturing "Extraordinary" Soft-Assembled Charge-Like Polypeptides as a Strategy for Nanocarrier Design.
Duro-Castano A, Nebot VJ, Niño-Pariente A, Armiñán A, Arroyo-Crespo JJ, Paul A, Feiner-Gracia N, Albertazzi L, Vicent MJ
Advanced materials (Deerfield Beach, Fla.) , 2017 Oct, vol. 29

Patents


Patent Application:Vicent J. Nebot; Aroa Duro-Castaño; Maria J. Vicent. Cross-linked Star-shaped self-assembled polyglutamates and its use as carriers in biomedical applications. N. Application: European patent EP15382422.2.08 August 2015.

Patent Application:María J. Vicent, Inma Conejos-Sánchez. Novel Polymer-drug conjugates for the treatment of amyloidosis. N. Application: European Patent EP13382184 20 May 2013.

FUNDACIÓN DE LA CV CENTRO DE INVESTIGACION PRÍNCIPE FELIPE participa en el proyecto "Desarrollo de una plataforma de terapia génica para enfermedades genéticas renales", expediente RTC-2017-6600-1, desarrollado en colaboración con las entidades VIRALGEN VECTOR CORE, PTS, FUNDACION PARA LA INVESTIGACIÓN MEDICA APLICADA, UNIVERSIDAD CARLOS III DE MADRID, que está siendo financiado por el Ministerio de Ciencia, Innovación y Universidades dentro del Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016, subprograma Retos-Colaboración, objetivo "Promover el desarrollo tecnológico, la innovación y una investigación de calidad", y cofinanciado con fondos FEDER.

FUNDACIÓN DE LA CV CENTRO DE INVESTIGACION PRÍNCIPE FELIPE participa en el proyecto "Desarrollo de terapias tópicas basadas en sistemas de transporte polipeptídicos", expediente RTC-2017-6465-1, desarrollado en colaboración con las entidades, PTS, UNIVERSITAT JAUME I DE CASTELLO, que está siendo financiado por el Ministerio de Ciencia, Innovación y Universidades dentro del Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016, subprograma Retos-Colaboración, objetivo "Promover el desarrollo tecnológico, la innovación y una investigación de calidad", y cofinanciado con fondos FEDER.

Agència Valenciana de la Innovació