Neuronal and Tissue Regeneration
The Neuronal and Tissue Regeneration Lab is working in the Regenerative Medicine field. We work to improve the success of the therapeutic applications of stem cell-based approaches on the clinical practice. The lab is focus on the adult stem cells characterization and therapeutic applications into much challenged associated-pathologies: Spinal cord Injury and Osteoarticular pathologies.
Spinal cord injury (SCI) results in an irreversible paralysis of the hind limb with no currently curable treatment. We showed that acute transplantation of activated ependymal stem/progenitor cell (epSPC) derivated from adult spinal cords can rescue lost neurological function after SCI in rodents (Stem Cells. 2009 Mar;27(3):733-43). The characterization of the "activation" process of the epSPC by the injury and its influence on its regenerative properties constitute an important experimental aim in our group. We aim to improve knowledge about the molecular and cellular process developed along the central nervous system injuries for a better understanding and search for pharmacological tools favoring the applied cell-based therapeutic strategies and look for synergistic effects within the pharmacological arsenal getting advantages on the application of new designed nanomedicine and biomaterials-based therapies.
Osteoarticular pathologies very often require a regeneration process for bone, cartilage and/or tendon with de novo vascularization. During the last couple of decades the mesenchymal stem cell population has been shown to be a much challenged option as a cell-based therapeutic approach. Because osteoarticular complications are very often occurring in dogs, it results as an ideal model for our studies with direct translational perspectives for the human application. In our lab we are involved in the generation and characterization of the adult adipose-derived mesenchymal cell population and its application on osteoarthritic associated pathology.
FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury.
Alastrue-Agudo A, Rodriguez-Jimenez FJ, Mocholi EL, De Giorgio F, Erceg S, Moreno-Manzano V
International journal of molecular sciences , 2018 Jan 9, vol. 19
Combined polymer-curcumin conjugate and ependymal progenitor/stem cell treatment enhances spinal cord injury functional recovery.
Requejo-Aguilar R, Alastrue-Agudo A, Cases-Villar M, Lopez-Mocholi E, England R, Vicent MJ, Moreno-Manzano V
Biomaterials , 2017 Jan, vol. 113, pag. 18-30
Human Suprapatellar Fat Pad-Derived Mesenchymal Stem Cells Induce Chondrogenesis and Cartilage Repair in a Model of Severe Osteoarthritis.
Muñoz-Criado I, Meseguer-Ripolles J, Mellado-López M, Alastrue-Agudo A, Griffeth RJ, Forteza-Vila J, Cugat R, García M, Moreno-Manzano V
Stem cells international , 2017, vol. 2017, pag. 4758930
Methacrylate-endcapped caprolactone and FM19G11 provide a proper niche for spinal cord-derived neural cells.
Valdes-Sánchez T, Rodriguez-Jimenez FJ, García-Cruz DM, Escobar-Ivirico JL, Alastrue-Agudo A, Erceg S, Monleón M, Moreno-Manzano V
Journal of tissue engineering and regenerative medicine , 2015 Jun, vol. 9, pag. 734-9
Purinergic Receptors in Spinal Cord-Derived Ependymal Stem/Progenitor Cells and Their Potential Role in Cell-Based Therapy for Spinal Cord Injury.
Gómez-Villafuertes R, Rodríguez-Jiménez FJ, Alastrue-Agudo A, Stojkovic M, Miras-Portugal MT, Moreno-Manzano V
Cell transplantation , 2015, vol. 24, pag. 1493-509