Stem Cell Therapies in Neurodegenerative Diseases
The focus of our group is development of new cell therapy approaches using pluripotent stem cells such as human embryonic stem (hES) cells and induced human pluripotent stem (ihPS) cells as well as adult stem cells in neurodegenerative diseases. Our aim is to develop clinically acceptable protocols for neural differentiation in animal-free conditions as therapeutic tool for treatment spinal cord injury, Parkinson disease and different types of ataxias and test them in animal models. We also apply combinatorial approaches using small molecules in order to increase the success of cell-based therapy.
Another subject of our interest is hereditary retinal dystrophies. We are particularly interested in creating new human retinal dystrophies disease models using patient-specific ihPS cells and their derivates, retinal pigment epithelial (RPE) cells and photoreceptors, in order to investigate the disease mechanisms, develop treatments, toxicity screens and model development. We are also optimizing RPE and photoreceptors derivation from ihPS cells as a cell source for transplantation therapy of retinal degeneration diseases.
Human iPSC derived disease model of MERTK-associated retinitis pigmentosa.
Lukovic D, Artero Castro A, Delgado AB, Bernal Mde L, Luna Pelaez N, Díez Lloret A, Perez Espejo R, Kamenarova K, Fernández Sánchez L, Cuenca N, Cortón M, Avila Fernandez A, Sorkio A, Skottman H, Ayuso C, Erceg S, Bhattacharya SS
Scientific reports , 2015 Aug 11, vol. 5, pag. 12910
Complete rat spinal cord transection as a faithful model of spinal cord injury for translational cell transplantation.
Lukovic D, Moreno-Manzano V, Lopez-Mocholi E, Rodriguez-Jiménez FJ, Jendelova P, Sykova E, Oria M, Stojkovic M, Erceg S
Scientific reports , 2015 Apr 10, vol. 5, pag. 9640
Brief report: astrogliosis promotes functional recovery of completely transected spinal cord following transplantation of hESC-derived oligodendrocyte and motoneuron progenitors.
Lukovic D, Valdés-Sanchez L, Sanchez-Vera I, Moreno-Manzano V, Stojkovic M, Bhattacharya SS, Erceg S
Stem cells (Dayton, Ohio) , 2014 Feb, vol. 32, pag. 594-9
Concise review: human pluripotent stem cells in the treatment of spinal cord injury.
Lukovic D, Moreno Manzano V, Stojkovic M, Bhattacharya SS, Erceg S
Stem cells (Dayton, Ohio) , 2012 Sep, vol. 30, pag. 1787-92, Impact Factor: 7.701
Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection.
Erceg S, Ronaghi M, Oria M, Roselló MG, Aragó MA, Lopez MG, Radojevic I, Moreno-Manzano V, Rodríguez-Jiménez FJ, Bhattacharya SS, Cordoba J, Stojkovic M
Stem cells (Dayton, Ohio) , 2010 Sep, vol. 28, pag. 1541-9, Impact Factor: 7.871