Stem Cell Therapies in Neurodegenerative Diseases
The focus of our group is development of new cell therapy approaches using pluripotent stem cells such as human embryonic stem (hES) cells and induced human pluripotent stem (ihPS) cells as well as adult stem cells in neurodegenerative diseases. Our aim is to develop clinically acceptable protocols for neural differentiation in animal-free conditions as therapeutic tool for treatment spinal cord injury, Parkinson disease and different types of ataxias and test them in animal models. We also apply combinatorial approaches using small molecules in order to increase the success of cell-based therapy.
Another subject of our interest is hereditary retinal dystrophies. We are particularly interested in creating new human retinal dystrophies disease models using patient-specific ihPS cells and their derivates, retinal pigment epithelial (RPE) cells and photoreceptors, in order to investigate the disease mechanisms, develop treatments, toxicity screens and model development. We are also optimizing RPE and photoreceptors derivation from ihPS cells as a cell source for transplantation therapy of retinal degeneration diseases.
Concise Review: Human Induced Pluripotent Stem Cell Models of Retinitis Pigmentosa.
Artero Castro A, Lukovic D, Jendelova P, Erceg S
Stem cells (Dayton, Ohio) , 2018 Apr, vol. 36, pag. 474-481
Highly Efficient Neural Conversion of Human Pluripotent Stem Cells in Adherent and Animal-Free Conditions.
Lukovic D, Diez Lloret A, Stojkovic P, Rodríguez-Martínez D, Perez Arago MA, Rodriguez-Jimenez FJ, González-Rodríguez P, López-Barneo J, Sykova E, Jendelova P, Kostic J, Moreno-Manzano V, Stojkovic M, Bhattacharya SS, Erceg S
Stem cells translational medicine , 2017 Feb 18,
hiPSC Disease Modeling of Rare Hereditary Cerebellar Ataxias.
Lukovic D, Moreno-Manzano V, Rodriguez-Jimenez FJ, Vilches A, Sykova E, Jendelova P, Stojkovic M, Erceg S
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry , 2016 Oct 1, , pag. 1073858416672652
Human iPSC derived disease model of MERTK-associated retinitis pigmentosa.
Lukovic D, Artero Castro A, Delgado AB, Bernal Mde L, Luna Pelaez N, Díez Lloret A, Perez Espejo R, Kamenarova K, Fernández Sánchez L, Cuenca N, Cortón M, Avila Fernandez A, Sorkio A, Skottman H, Ayuso C, Erceg S, Bhattacharya SS
Scientific reports , 2015 Aug 11, vol. 5, pag. 12910
Brief report: astrogliosis promotes functional recovery of completely transected spinal cord following transplantation of hESC-derived oligodendrocyte and motoneuron progenitors.
Lukovic D, Valdés-Sanchez L, Sanchez-Vera I, Moreno-Manzano V, Stojkovic M, Bhattacharya SS, Erceg S
Stem cells (Dayton, Ohio) , 2014 Feb, vol. 32, pag. 594-9