Slide STEM CELL THERAPIES IN
NEURODEGENERATIVE DISEASES
Slaven Erceg



The focus of our group is development of new cell therapy.

The focus of our group is development of new cell therapy approaches using pluripotent stem cells, such as human embryonic stem cells (hESC) and induced human pluripotent stem cells (hiPSC), as well as adult stem cells in neurodegenerative diseases. Our aim is to develop clinically acceptable protocols for neural differentiation and to test them in different animal models as therapeutic tool for treatment spinal cord injury and different types of ataxias. We also apply combinatorial approaches using small molecules in order to increase the success of cell-based therapy.

Another subject of our interest is hereditary retinal dystrophies. We are particularly interested in creating new human cellular models using patient-specific hiPSC and their derivates, retinal pigment epithelial (RPE) cells and optic-cup organoids, in order to investigate the disease mechanisms, develop treatments, toxicity screens and model development. Using our hiPSC expertise, we have been able to establish hiPSC from patients suffering from retinitis pigmentosa. Moreover, we intend to correct the faulty genes in these cells using Crispr/Cas9 technology and optimize RPE and photoreceptors derivation from corrected hiPSC as a cell source for transplantation therapy of retinal degeneration diseases.

In collaboration with other laboratories, we are developing new tools for delivering RPE and photoreceptor cells with high viability into degenerate retina in small and large animal models.

Presentation

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Research Staff

People who make it possible

Slaven Erceg Vukicevic
serceg@cipf.es

Francisco Rodríguez Jiménez
frodriguez@cipf.es

Ana Artero Castro
aartero@cipf.es

Maria Amp Pérez Arago
mparago@cipf.es

Francisca Selles Sorli
fselles@cipf.es

Publications

Our contribution to science

Concise Review: Human Induced Pluripotent Stem Cell Models of Retinitis Pigmentosa
A. CASTRO, D. LUKOVIC, P. JENDELOVA and S. ERCEG
STEM CELLS, 2018 Apr,  Vol. 36,  pag. 474-481

Highly Efficient Neural Conversion of Human Pluripotent Stem Cells in Adherent and Animal-Free Conditions
D. LUKOVIC, A. LLORET, P. STOJKOVIC, D. RODRIGUEZ-MARTINEZ, M. ARAGO, F. RODRIGUEZ-JIMENEZ, P. GONZALEZ-RODRIGUEZ, J. LOPEZ-BARNEO, E. SYKOVA, P. JENDELOVA, J. KOSTIC, V. MORENO-MANZANO, M. STOJKOVIC, S. BHATTACHARYA and S. ERCEG
Stem Cells Translational Medicine, 2017 Apr,  Vol. 6,  pag. 1217-1226

hiPSC Disease Modeling of Rare Hereditary Cerebellar Ataxias: Opportunities and Future Challenges
D. LUKOVIC, V. MORENO-MANZANO, F. RODRIGUEZ-JIMENEZ, A. VILCHES, E. SYKOVA, P. JENDELOVA, M. STOJKOVIC and S. ERCEG
NEUROSCIENTIST, 2017 Oct,  Vol. 23,  pag. 554-566

Human iPSC derived disease model of MERTK-associated retinitis pigmentosa
D. LUKOVIC, A. CASTRO, A. DELGADO, M. BERNAL, N. PELAEZ, A. LLORET, R. ESPEJO, K. KAMENAROVA, L. SANCHEZ, N. CUENCA, M. CORTON, A. FERNANDEZ, A. SORKIO, H. SKOTTMAN, C. AYUSO, S. ERCEG VUKICEVIC and S. BHATTACHARYA
Scientific Reports, 2015 Aug,  Vol. 5,  pag. 12910

Brief Report: Astrogliosis Promotes Functional Recovery of Completely Transected Spinal Cord Following Transplantation of hESC-Derived Oligodendrocyte and Motoneuron Progenitors
D. LUKOVIC, L. VALDES-SANCHEZ, I. SANCHEZ-VERA, V. MORENO-MANZANO, M. STOJKOVIC, S. BHATTACHARYA and S. ERCEG
STEM CELLS, 2014 Feb,  Vol. 32,  pag. 594-599

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