Bryan Strange, Guillermo Velasco
Highlights
stay up to date
Latest News
Updates on our activities
working on the following programs
PATHOLOGIES
PATHOLOGIES
upcoming events
Save the date!
april
18apr12:3013:30FBR: Dr. Frank Westermann
Event Details
Developmental programs in childhood embryonal tumors Speaker: Prof. Frank Westermann Institution: Neuroblastoma Research Group, Head Division, Hopp-Children’s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany. Place: Jerónimo Forteza conference room, CIPF
Event Details
Developmental programs in childhood embryonal tumors
Speaker: Prof. Frank Westermann
Institution: Neuroblastoma Research Group, Head Division, Hopp-Children’s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Place: Jerónimo Forteza conference room, CIPF
Abstract: A prominent disparity between pediatric and adult cancers lies in the considerably lower mutational burden observed in pediatric malignancies. Unlike their adult counterparts, which often develop as a result of the gradual accumulation of genetic alterations over a longer lifespan, pediatric tumors originate in a relative short time from embryonic tissues that have undergone limited mutational changes. This lower genetic complexity is a distinctive feature of pediatric cancers and may point towards dependencies linked to fewer oncogenic drivers. Beyond mutational differences, the cell of origin plays a pivotal role in shaping the characteristics of pediatric cancers. Pediatric tumors (e.g., neuroblastoma, medulloblastoma, Ewing sarcoma) typically originate from fast-proliferating embryonic or fetal tissues, in contrast to adult cancers that predominantly arise from mature tissues with few cycling cells. Here, we studied the developing adrenal glands, sympathetic ganglia and neural crest tissue covering various developmental stages using single-nucleus RNA sequencing (snRNA-seq) to shed light on the normal development of sympathoadrenal cells in humans. Furthermore, childhood neuroblastomas were studied by snRNA-seq and their transcriptomes were compared to developing normal sympathoadrenal cells to gain insights into the developmental origins of neuroblastoma. In combination with functional genomic approaches, these transcriptome comparisons can be used to study the impact of oncogenes and tumor suppressor genes in neuroblastoma biology. Furthermore, we quantified somatic evolution of neuroblastomas by deep whole-genome sequencing, molecular clock analysis and population-genetic modeling in a comprehensive cohort covering all subtypes. We find that tumors across the entire clinical spectrum begin to develop via aberrant mitoses as early as in the first trimester of pregnancy. Neuroblastomas with favorable prognosis cease to evolve early, whereas aggressive neuroblastomas show prolonged evolution during which they acquire telomere maintenance mechanisms. In summary, understanding the developmental context and evolution of embryonal tumors is essential to identify unique vulnerabilities allowing for tailoring treatment approaches and optimizing outcomes.
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Thursday) 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
25apr12:0013:00SEMINAR: Edna Ripollés / Jesús Alejandro Alzate
Event Details
12:00 – 12:30 Edna Ripollés Potential gut microbiota-associated biomarkers in Wilson Disease The gut microbiota (GM) makes an axis with various extraintestinal organs, including the liver or brain.
Event Details
12:00 – 12:30 Edna Ripollés
Potential gut microbiota-associated biomarkers in Wilson Disease
The gut microbiota (GM) makes an axis with various extraintestinal organs, including the liver or brain. This interconnection is regulated by an intricate metabolic, endocrine, and immune host-microbe crosstalk. In this seminar, we will discuss preliminary findings related to the characterization of intestinal microbiota associated with Wilson’s disease, a rare disease characterized by toxic copper accumulation that affects the liver and nervous system. Our main aim is to identify potential bacterial biomarkers that could provide insight into the etiopathogenic mechanisms of the disease and facilitate the development of novel diagnostic and treatment strategies
12:30 – 13:00 Jesús Alejandro Alzate
Integrating AI and Data Science in Medical Imaging: A Prostate Cancer Application
In the evolving healthcare sector, the fusion of artificial intelligence (AI) and data science with medical imaging is introducing a new era of diagnostic precision. In this seminar, we will present the collaborative efforts of the Joint Biomedical Imaging Unit (Unidad Mixta de Imagén Biomédica) in applying these techniques to medical imaging, focusing on a global problematic such as prostate cancer detection.
Time
(Thursday) 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
may
16may12:0013:00SEMINAR: Marina Fuertes Agudo / Daniel Tena González
Event Details
12:00 – 12:30 Marina Fuertes Agudo 3D cell cultures for modeling liver pathologies Abstract 12:30 – 13:00 Daniel Tena González Inhibition of NLRP3 inflammasome in models of retinal degenerations
Event Details
12:00 – 12:30 Marina Fuertes Agudo
3D cell cultures for modeling liver pathologies
Abstract
12:30 – 13:00 Daniel Tena González
Inhibition of NLRP3 inflammasome in models of retinal degenerations
Abstract
Time
(Thursday) 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
24mayAll DayJuli PeretóA CREATIVE PLANET: HOW DID LIFE ON EARTH EMERGE?
Event Details
A CREATIVE PLANET: HOW DID LIFE ON EARTH EMERGE? Juli Peretó I2SYSBIO CSIC-UV Mayo 24 a las 12:30h Salón de Actos CIPF Abstract: The transition from geochemistry to biochemistry took
Event Details
A CREATIVE PLANET: HOW DID LIFE ON EARTH EMERGE?
Juli Peretó I2SYSBIO CSIC-UV
Mayo 24 a las 12:30h
Salón de Actos CIPF
Abstract: The transition from geochemistry to biochemistry took place on Earth some 4 billion years ago. How did the chemistry of the early planet organise itself into systems capable of obtaining matter and energy from the environment and making more copies of themselves? And how did these simple biological systems unfold to generate so much biodiversity? The difficulties of scientific study of the origin of life are enormous, since we do not know most of the details of what the planet was like at that time, and there are hardly any remains of the most primitive cells. The classic proposals of Oparin and Haldane, a century ago, put speculation to rest and opened the way for empirical studies. From the pioneering experiments of Miller and Oró to the most recent approaches of systems chemistry, a long road has been travelled that allows us to recreate today in the laboratory many processes analogous to those that could have occurred during the chemical origin of life on Earth. Admittedly, as in all research of a historical nature, we will never know exactly how chemistry came to life, but this does not prevent us from taking on one of the most colossal and exciting scientific challenges, an unfinished and never-ending scientific programme.
Juli Peretó is professor in the Department of Biochemistry and Molecular Biology (University of Valencia) and full member of the Institut d’Estudis Catalans. He was co-director-founder of the Institute for Integrative Systems Biology (I2SysBio, a joint University of Valencia-CSIC centre) of which he is a member of the Biotechnology and Synthetic Biology group. His research interests include the evolution of metabolism, the concept of the minimal cell, the bioprospecting of inhospitable habitats and the history of ideas about the natural origin and artificial synthesis of life. He tries to teach metabolism with an evolutionary flair to biologists, biochemists and biotechnologists. He was Secretary and Vice-President of the International Society for the Study of the Origin of Life (ISSOL), of which he was elected Fellow in 2014. He is co-founder of the company Darwin Bioprospecting Excellence SL, a spin-off of the University of Valencia installed in its Science Park. Some of his recent books are “Synthetic Biology: from iGEM to the artificial cell” (Springer, 2014), co-authored with M. Porcar, “Science at the table”, a collection of articles on scientific gastronomy by F. Sapiña (Monografies Mètode, 2019), “Illuminating human evolution, 150 years after Darwin”, co-edited with J. Bertranpetit (Springer 2022), and “Un planeta creatiu: com va començar la vida a la Terra i com la fabricarem al laboratori” (Institució Alfons el Magnànim, 2023).
Time
All Day (Friday)(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
june
07junAll DayElisa MartiBuilding Human Spinal Cord Organoids: Biomodels to Study Neural Tube Defects
Event Details
Conference Building Human Spinal Cord Organoids: Biomodels to Study Neural Tube Defects Elisa Marti Instituto Biología Molecular de Barcelona IBMB-CSIC
Event Details
Conference
Building Human Spinal Cord Organoids: Biomodels to Study Neural Tube Defects
Elisa Marti
Instituto Biología Molecular de Barcelona IBMB-CSIC
Time
All Day (Friday)(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
13jun12:3013:30FBR: Carlos Guillén
Event Details
Title Speaker: Carlos Guillén Institution: Diabetes & Obesity Lab, Universidad Complutense de Madrid, Madrid, Spain Place: Jerónimo Forteza conference room, CIPF Abstract: PATROCINADO POR: With support
Event Details
Title
Speaker: Carlos Guillén
Institution: Diabetes & Obesity Lab, Universidad Complutense de Madrid, Madrid, Spain
Place: Jerónimo Forteza conference room, CIPF
Abstract:
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Thursday) 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
27jun12:0013:00SEMINAR: Mª del Mar Sánchez / Mohammed M. Anwar
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín Title Abstract 12:30 – 13:00 Mohammed M. Anwar Title Abstract
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín
Title
Abstract
12:30 – 13:00 Mohammed M. Anwar
Title
Abstract
Time
(Thursday) 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
18apr12:3013:30FBR: Dr. Frank Westermann
Event Details
Developmental programs in childhood embryonal tumors Speaker: Prof. Frank Westermann Institution: Neuroblastoma Research Group, Head Division, Hopp-Children’s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany. Place: Jerónimo Forteza conference room, CIPF
Event Details
Developmental programs in childhood embryonal tumors
Speaker: Prof. Frank Westermann
Institution: Neuroblastoma Research Group, Head Division, Hopp-Children’s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Place: Jerónimo Forteza conference room, CIPF
Abstract: A prominent disparity between pediatric and adult cancers lies in the considerably lower mutational burden observed in pediatric malignancies. Unlike their adult counterparts, which often develop as a result of the gradual accumulation of genetic alterations over a longer lifespan, pediatric tumors originate in a relative short time from embryonic tissues that have undergone limited mutational changes. This lower genetic complexity is a distinctive feature of pediatric cancers and may point towards dependencies linked to fewer oncogenic drivers. Beyond mutational differences, the cell of origin plays a pivotal role in shaping the characteristics of pediatric cancers. Pediatric tumors (e.g., neuroblastoma, medulloblastoma, Ewing sarcoma) typically originate from fast-proliferating embryonic or fetal tissues, in contrast to adult cancers that predominantly arise from mature tissues with few cycling cells. Here, we studied the developing adrenal glands, sympathetic ganglia and neural crest tissue covering various developmental stages using single-nucleus RNA sequencing (snRNA-seq) to shed light on the normal development of sympathoadrenal cells in humans. Furthermore, childhood neuroblastomas were studied by snRNA-seq and their transcriptomes were compared to developing normal sympathoadrenal cells to gain insights into the developmental origins of neuroblastoma. In combination with functional genomic approaches, these transcriptome comparisons can be used to study the impact of oncogenes and tumor suppressor genes in neuroblastoma biology. Furthermore, we quantified somatic evolution of neuroblastomas by deep whole-genome sequencing, molecular clock analysis and population-genetic modeling in a comprehensive cohort covering all subtypes. We find that tumors across the entire clinical spectrum begin to develop via aberrant mitoses as early as in the first trimester of pregnancy. Neuroblastomas with favorable prognosis cease to evolve early, whereas aggressive neuroblastomas show prolonged evolution during which they acquire telomere maintenance mechanisms. In summary, understanding the developmental context and evolution of embryonal tumors is essential to identify unique vulnerabilities allowing for tailoring treatment approaches and optimizing outcomes.
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Thursday) 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
25apr12:0013:00SEMINAR: Edna Ripollés / Jesús Alejandro Alzate
Event Details
12:00 – 12:30 Edna Ripollés Potential gut microbiota-associated biomarkers in Wilson Disease The gut microbiota (GM) makes an axis with various extraintestinal organs, including the liver or brain.
Event Details
12:00 – 12:30 Edna Ripollés
Potential gut microbiota-associated biomarkers in Wilson Disease
The gut microbiota (GM) makes an axis with various extraintestinal organs, including the liver or brain. This interconnection is regulated by an intricate metabolic, endocrine, and immune host-microbe crosstalk. In this seminar, we will discuss preliminary findings related to the characterization of intestinal microbiota associated with Wilson’s disease, a rare disease characterized by toxic copper accumulation that affects the liver and nervous system. Our main aim is to identify potential bacterial biomarkers that could provide insight into the etiopathogenic mechanisms of the disease and facilitate the development of novel diagnostic and treatment strategies
12:30 – 13:00 Jesús Alejandro Alzate
Integrating AI and Data Science in Medical Imaging: A Prostate Cancer Application
In the evolving healthcare sector, the fusion of artificial intelligence (AI) and data science with medical imaging is introducing a new era of diagnostic precision. In this seminar, we will present the collaborative efforts of the Joint Biomedical Imaging Unit (Unidad Mixta de Imagén Biomédica) in applying these techniques to medical imaging, focusing on a global problematic such as prostate cancer detection.
Time
(Thursday) 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
16may12:0013:00SEMINAR: Marina Fuertes Agudo / Daniel Tena González
Event Details
12:00 – 12:30 Marina Fuertes Agudo 3D cell cultures for modeling liver pathologies Abstract 12:30 – 13:00 Daniel Tena González Inhibition of NLRP3 inflammasome in models of retinal degenerations
Event Details
12:00 – 12:30 Marina Fuertes Agudo
3D cell cultures for modeling liver pathologies
Abstract
12:30 – 13:00 Daniel Tena González
Inhibition of NLRP3 inflammasome in models of retinal degenerations
Abstract
Time
(Thursday) 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
24mayAll DayJuli PeretóA CREATIVE PLANET: HOW DID LIFE ON EARTH EMERGE?
Event Details
A CREATIVE PLANET: HOW DID LIFE ON EARTH EMERGE? Juli Peretó I2SYSBIO CSIC-UV Mayo 24 a las 12:30h Salón de Actos CIPF Abstract: The transition from geochemistry to biochemistry took
Event Details
A CREATIVE PLANET: HOW DID LIFE ON EARTH EMERGE?
Juli Peretó I2SYSBIO CSIC-UV
Mayo 24 a las 12:30h
Salón de Actos CIPF
Abstract: The transition from geochemistry to biochemistry took place on Earth some 4 billion years ago. How did the chemistry of the early planet organise itself into systems capable of obtaining matter and energy from the environment and making more copies of themselves? And how did these simple biological systems unfold to generate so much biodiversity? The difficulties of scientific study of the origin of life are enormous, since we do not know most of the details of what the planet was like at that time, and there are hardly any remains of the most primitive cells. The classic proposals of Oparin and Haldane, a century ago, put speculation to rest and opened the way for empirical studies. From the pioneering experiments of Miller and Oró to the most recent approaches of systems chemistry, a long road has been travelled that allows us to recreate today in the laboratory many processes analogous to those that could have occurred during the chemical origin of life on Earth. Admittedly, as in all research of a historical nature, we will never know exactly how chemistry came to life, but this does not prevent us from taking on one of the most colossal and exciting scientific challenges, an unfinished and never-ending scientific programme.
Juli Peretó is professor in the Department of Biochemistry and Molecular Biology (University of Valencia) and full member of the Institut d’Estudis Catalans. He was co-director-founder of the Institute for Integrative Systems Biology (I2SysBio, a joint University of Valencia-CSIC centre) of which he is a member of the Biotechnology and Synthetic Biology group. His research interests include the evolution of metabolism, the concept of the minimal cell, the bioprospecting of inhospitable habitats and the history of ideas about the natural origin and artificial synthesis of life. He tries to teach metabolism with an evolutionary flair to biologists, biochemists and biotechnologists. He was Secretary and Vice-President of the International Society for the Study of the Origin of Life (ISSOL), of which he was elected Fellow in 2014. He is co-founder of the company Darwin Bioprospecting Excellence SL, a spin-off of the University of Valencia installed in its Science Park. Some of his recent books are “Synthetic Biology: from iGEM to the artificial cell” (Springer, 2014), co-authored with M. Porcar, “Science at the table”, a collection of articles on scientific gastronomy by F. Sapiña (Monografies Mètode, 2019), “Illuminating human evolution, 150 years after Darwin”, co-edited with J. Bertranpetit (Springer 2022), and “Un planeta creatiu: com va començar la vida a la Terra i com la fabricarem al laboratori” (Institució Alfons el Magnànim, 2023).
Time
All Day (Friday)(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
07junAll DayElisa MartiBuilding Human Spinal Cord Organoids: Biomodels to Study Neural Tube Defects
Event Details
Conference Building Human Spinal Cord Organoids: Biomodels to Study Neural Tube Defects Elisa Marti Instituto Biología Molecular de Barcelona IBMB-CSIC
Event Details
Conference
Building Human Spinal Cord Organoids: Biomodels to Study Neural Tube Defects
Elisa Marti
Instituto Biología Molecular de Barcelona IBMB-CSIC
Time
All Day (Friday)(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
13jun12:3013:30FBR: Carlos Guillén
Event Details
Title Speaker: Carlos Guillén Institution: Diabetes & Obesity Lab, Universidad Complutense de Madrid, Madrid, Spain Place: Jerónimo Forteza conference room, CIPF Abstract: PATROCINADO POR: With support
Event Details
Title
Speaker: Carlos Guillén
Institution: Diabetes & Obesity Lab, Universidad Complutense de Madrid, Madrid, Spain
Place: Jerónimo Forteza conference room, CIPF
Abstract:
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Thursday) 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
27jun12:0013:00SEMINAR: Mª del Mar Sánchez / Mohammed M. Anwar
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín Title Abstract 12:30 – 13:00 Mohammed M. Anwar Title Abstract
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín
Title
Abstract
12:30 – 13:00 Mohammed M. Anwar
Title
Abstract
Time
(Thursday) 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
lectures
SHARING knowledge
Eva Hernando Monge
Mechanisms of neural mimicry during melanoma metastasis Speaker: Eva Hernando-Monge...
DISCOVER
meet our scientists
NEURODEGENERATIVE DISORDERS
CANCER AND INFLAMMATION
AND REGERENATIVE MEDICINE
MIGRATION AND CANCER INVASION
BIOENGINEERING
HOST-MICROBIOME INTERACTIONS