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20jan12:3013:30FBR: Toby LawrenceOntogeny and function of tumour-associated macrophages
Event Details
Speaker: Toby Lawrence Institution: Centre for Inflammation Biology and Cancer Immunology, King’s College London. London, United Kingdom Place: CIPF conference room Title: Ontogeny and function of tumour-associated macrophages Abstract:
Event Details
Speaker: Toby Lawrence
Institution: Centre for Inflammation Biology and Cancer Immunology, King’s College London. London, United Kingdom
Place: CIPF conference room
Title: Ontogeny and function of tumour-associated macrophages
Abstract:
There is now a wealth of clinical and experimental evidence that strongly links the accumulation of tumour-associated macrophages (TAM) with cancer progression, invasion and metastasis. In the vast majority of published studies increased numbers of TAM correlate with poor prognosis, but in some cases, specific TAM subsets have been associated with beneficial outcomes – which may reflect their roles in orchestrating protective immune responses. In fact, recent studies using paired single cell analysis by mass cytometry and RNA sequencing, have revealed an unprecedented level of diversity among TAM in human cancer. But will still understand little about the significance of TAM heterogeneity and the functions of different TAM subsets in disease progression, which is critical to design more targeted therapies.
We have characterised the ontogeny and function of different TAM subsets in experimental models of cancer. We have demonstrated that a subset of monocyte-derived macrophages (MDM) that express the scavenger receptor CD163, exert profound immune-suppressive functions and prevent the mobilisation of anti-tumour immune responses. In other studies, we have characterised subsets of tissue-resident macrophages of embryonic origins (TRM), which specifically promote the invasive activity of disseminated cancer cells and the metastatic spread of disease. Our studies suggest monocyte-derived and tissue-resident TAM subsets have divergent functions in tumour progression and we are actively exploring the molecular basis of TAM diversity.
Time
(Friday) 12:30 - 13:30
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
Event Details
Thesis Title: The inflammatory tumor microenvironment as a target in the design of nanoconjugates for the treatment of advanced breast cancer Author: Paula Soriano Teruel PhD. Supervisors: Mar Orzáez, Mª Jesús Vicent
Event Details
Thesis Title: The inflammatory tumor microenvironment as a target in the design of nanoconjugates for the treatment of advanced breast cancer
Author: Paula Soriano Teruel
PhD. Supervisors: Mar Orzáez, Mª Jesús Vicent
Summary:
This thesis focuses on the evaluation of a novel inflammasome inhibitor (MM01) as a chemical tool to study the role of the inflammasome in models of inflammation and cancer.
In this work we delineate a novel mechanism of action for MM01, a recently identified modulator of inflammasome activity. We demonstrate that MM01 disrupts ASC oligomerization, a process associated with the activity of various inflammasomes, and inhibits downstream IL-1β release and death by pyroptosis in various cellular and in vivo models of inflammation. We have employed MM01, to study the role of the inflammasome in tumor progression in different breast cancer models both in vitro and in vivo, and developed a synthetic strategy to obtain a novel nanomedicine that improved the solubility and tumor-targeting capabilities of MM01 in breast cancer.
Time
(Friday) 12:00 - 14:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
31jan11:3013:30Jornada Epiforward: la voz de la epilepsia
Time
(Tuesday) 11:30 - 13:30
Organizer




THERAPIES
upcoming events
Save the date!
20jan12:3013:30FBR: Toby LawrenceOntogeny and function of tumour-associated macrophages
Event Details
Speaker: Toby Lawrence Institution: Centre for Inflammation Biology and Cancer Immunology, King’s College London. London, United Kingdom Place: CIPF conference room Title: Ontogeny and function of tumour-associated macrophages Abstract:
Event Details
Speaker: Toby Lawrence
Institution: Centre for Inflammation Biology and Cancer Immunology, King’s College London. London, United Kingdom
Place: CIPF conference room
Title: Ontogeny and function of tumour-associated macrophages
Abstract:
There is now a wealth of clinical and experimental evidence that strongly links the accumulation of tumour-associated macrophages (TAM) with cancer progression, invasion and metastasis. In the vast majority of published studies increased numbers of TAM correlate with poor prognosis, but in some cases, specific TAM subsets have been associated with beneficial outcomes – which may reflect their roles in orchestrating protective immune responses. In fact, recent studies using paired single cell analysis by mass cytometry and RNA sequencing, have revealed an unprecedented level of diversity among TAM in human cancer. But will still understand little about the significance of TAM heterogeneity and the functions of different TAM subsets in disease progression, which is critical to design more targeted therapies.
We have characterised the ontogeny and function of different TAM subsets in experimental models of cancer. We have demonstrated that a subset of monocyte-derived macrophages (MDM) that express the scavenger receptor CD163, exert profound immune-suppressive functions and prevent the mobilisation of anti-tumour immune responses. In other studies, we have characterised subsets of tissue-resident macrophages of embryonic origins (TRM), which specifically promote the invasive activity of disseminated cancer cells and the metastatic spread of disease. Our studies suggest monocyte-derived and tissue-resident TAM subsets have divergent functions in tumour progression and we are actively exploring the molecular basis of TAM diversity.
Time
(Friday) 12:30 - 13:30
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
Event Details
Thesis Title: The inflammatory tumor microenvironment as a target in the design of nanoconjugates for the treatment of advanced breast cancer Author: Paula Soriano Teruel PhD. Supervisors: Mar Orzáez, Mª Jesús Vicent
Event Details
Thesis Title: The inflammatory tumor microenvironment as a target in the design of nanoconjugates for the treatment of advanced breast cancer
Author: Paula Soriano Teruel
PhD. Supervisors: Mar Orzáez, Mª Jesús Vicent
Summary:
This thesis focuses on the evaluation of a novel inflammasome inhibitor (MM01) as a chemical tool to study the role of the inflammasome in models of inflammation and cancer.
In this work we delineate a novel mechanism of action for MM01, a recently identified modulator of inflammasome activity. We demonstrate that MM01 disrupts ASC oligomerization, a process associated with the activity of various inflammasomes, and inhibits downstream IL-1β release and death by pyroptosis in various cellular and in vivo models of inflammation. We have employed MM01, to study the role of the inflammasome in tumor progression in different breast cancer models both in vitro and in vivo, and developed a synthetic strategy to obtain a novel nanomedicine that improved the solubility and tumor-targeting capabilities of MM01 in breast cancer.
Time
(Friday) 12:00 - 14:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
31jan11:3013:30Jornada Epiforward: la voz de la epilepsia
Time
(Tuesday) 11:30 - 13:30
Organizer
05may12:3013:30FBR: Jochen Prehn
Event Details
Speaker: Jochen Prehn Institution: Physiology and Medical Physics Department, Centre for Systems Medicine, Royal College of Surgeons in Ireland. Dublin, Ireland Place: CIPF conference room Abstract:
Event Details
Speaker: Jochen Prehn
Institution: Physiology and Medical Physics Department, Centre for Systems Medicine, Royal College of Surgeons in Ireland. Dublin, Ireland
Place: CIPF conference room
Abstract:
Time
(Friday) 12:30 - 13:30
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
26may12:0013:00SEMINAR: Milagros Buffa / María Ibáñez
Event Details
12:00 – 12:30 Milagros Buffa 12:30 – 13:00 María Ibáñez
Event Details
12:00 – 12:30 Milagros Buffa
12:30 – 13:00 María Ibáñez
Time
(Friday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
No Events
20jan12:3013:30FBR: Toby LawrenceOntogeny and function of tumour-associated macrophages
Event Details
Speaker: Toby Lawrence Institution: Centre for Inflammation Biology and Cancer Immunology, King’s College London. London, United Kingdom Place: CIPF conference room Title: Ontogeny and function of tumour-associated macrophages Abstract:
Event Details
Speaker: Toby Lawrence
Institution: Centre for Inflammation Biology and Cancer Immunology, King’s College London. London, United Kingdom
Place: CIPF conference room
Title: Ontogeny and function of tumour-associated macrophages
Abstract:
There is now a wealth of clinical and experimental evidence that strongly links the accumulation of tumour-associated macrophages (TAM) with cancer progression, invasion and metastasis. In the vast majority of published studies increased numbers of TAM correlate with poor prognosis, but in some cases, specific TAM subsets have been associated with beneficial outcomes – which may reflect their roles in orchestrating protective immune responses. In fact, recent studies using paired single cell analysis by mass cytometry and RNA sequencing, have revealed an unprecedented level of diversity among TAM in human cancer. But will still understand little about the significance of TAM heterogeneity and the functions of different TAM subsets in disease progression, which is critical to design more targeted therapies.
We have characterised the ontogeny and function of different TAM subsets in experimental models of cancer. We have demonstrated that a subset of monocyte-derived macrophages (MDM) that express the scavenger receptor CD163, exert profound immune-suppressive functions and prevent the mobilisation of anti-tumour immune responses. In other studies, we have characterised subsets of tissue-resident macrophages of embryonic origins (TRM), which specifically promote the invasive activity of disseminated cancer cells and the metastatic spread of disease. Our studies suggest monocyte-derived and tissue-resident TAM subsets have divergent functions in tumour progression and we are actively exploring the molecular basis of TAM diversity.
Time
(Friday) 12:30 - 13:30
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
Event Details
Thesis Title: The inflammatory tumor microenvironment as a target in the design of nanoconjugates for the treatment of advanced breast cancer Author: Paula Soriano Teruel PhD. Supervisors: Mar Orzáez, Mª Jesús Vicent
Event Details
Thesis Title: The inflammatory tumor microenvironment as a target in the design of nanoconjugates for the treatment of advanced breast cancer
Author: Paula Soriano Teruel
PhD. Supervisors: Mar Orzáez, Mª Jesús Vicent
Summary:
This thesis focuses on the evaluation of a novel inflammasome inhibitor (MM01) as a chemical tool to study the role of the inflammasome in models of inflammation and cancer.
In this work we delineate a novel mechanism of action for MM01, a recently identified modulator of inflammasome activity. We demonstrate that MM01 disrupts ASC oligomerization, a process associated with the activity of various inflammasomes, and inhibits downstream IL-1β release and death by pyroptosis in various cellular and in vivo models of inflammation. We have employed MM01, to study the role of the inflammasome in tumor progression in different breast cancer models both in vitro and in vivo, and developed a synthetic strategy to obtain a novel nanomedicine that improved the solubility and tumor-targeting capabilities of MM01 in breast cancer.
Time
(Friday) 12:00 - 14:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
31jan11:3013:30Jornada Epiforward: la voz de la epilepsia
Time
(Tuesday) 11:30 - 13:30
Organizer
20jan12:3013:30FBR: Toby LawrenceOntogeny and function of tumour-associated macrophages
Event Details
Speaker: Toby Lawrence Institution: Centre for Inflammation Biology and Cancer Immunology, King’s College London. London, United Kingdom Place: CIPF conference room Title: Ontogeny and function of tumour-associated macrophages Abstract:
Event Details
Speaker: Toby Lawrence
Institution: Centre for Inflammation Biology and Cancer Immunology, King’s College London. London, United Kingdom
Place: CIPF conference room
Title: Ontogeny and function of tumour-associated macrophages
Abstract:
There is now a wealth of clinical and experimental evidence that strongly links the accumulation of tumour-associated macrophages (TAM) with cancer progression, invasion and metastasis. In the vast majority of published studies increased numbers of TAM correlate with poor prognosis, but in some cases, specific TAM subsets have been associated with beneficial outcomes – which may reflect their roles in orchestrating protective immune responses. In fact, recent studies using paired single cell analysis by mass cytometry and RNA sequencing, have revealed an unprecedented level of diversity among TAM in human cancer. But will still understand little about the significance of TAM heterogeneity and the functions of different TAM subsets in disease progression, which is critical to design more targeted therapies.
We have characterised the ontogeny and function of different TAM subsets in experimental models of cancer. We have demonstrated that a subset of monocyte-derived macrophages (MDM) that express the scavenger receptor CD163, exert profound immune-suppressive functions and prevent the mobilisation of anti-tumour immune responses. In other studies, we have characterised subsets of tissue-resident macrophages of embryonic origins (TRM), which specifically promote the invasive activity of disseminated cancer cells and the metastatic spread of disease. Our studies suggest monocyte-derived and tissue-resident TAM subsets have divergent functions in tumour progression and we are actively exploring the molecular basis of TAM diversity.
Time
(Friday) 12:30 - 13:30
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
Event Details
Thesis Title: The inflammatory tumor microenvironment as a target in the design of nanoconjugates for the treatment of advanced breast cancer Author: Paula Soriano Teruel PhD. Supervisors: Mar Orzáez, Mª Jesús Vicent
Event Details
Thesis Title: The inflammatory tumor microenvironment as a target in the design of nanoconjugates for the treatment of advanced breast cancer
Author: Paula Soriano Teruel
PhD. Supervisors: Mar Orzáez, Mª Jesús Vicent
Summary:
This thesis focuses on the evaluation of a novel inflammasome inhibitor (MM01) as a chemical tool to study the role of the inflammasome in models of inflammation and cancer.
In this work we delineate a novel mechanism of action for MM01, a recently identified modulator of inflammasome activity. We demonstrate that MM01 disrupts ASC oligomerization, a process associated with the activity of various inflammasomes, and inhibits downstream IL-1β release and death by pyroptosis in various cellular and in vivo models of inflammation. We have employed MM01, to study the role of the inflammasome in tumor progression in different breast cancer models both in vitro and in vivo, and developed a synthetic strategy to obtain a novel nanomedicine that improved the solubility and tumor-targeting capabilities of MM01 in breast cancer.
Time
(Friday) 12:00 - 14:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
31jan11:3013:30Jornada Epiforward: la voz de la epilepsia
Time
(Tuesday) 11:30 - 13:30
Organizer
17feb09:3014:00VII Jornada Nacional de Investigadoras en Enfermedades Raras
Event Details
VII Jornada Nacional de Investigadoras en Enfermedades Raras —- PULSE AQUÍ PARA INSCRIBIRSE —-
Event Details
Time
(Friday) 09:30 - 14:00
03mar12:3013:30FBR: Marta Cascante
Event Details
Speaker: Marta Cascante Institution: Integrative Systems Biology, Metabolomics and Cancer Lab, Biomedicine Institute, University of Barcelona. Barcelona, Spain. Place: CIPF conference room Abstract:
Event Details
Speaker: Marta Cascante
Institution: Integrative Systems Biology, Metabolomics and Cancer Lab, Biomedicine Institute, University of Barcelona. Barcelona, Spain.
Place: CIPF conference room
Abstract:
Time
(Friday) 12:30 - 13:30
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
10mar12:0013:00SEMINAR: Camilla Pegoraro / Francesca de Angelis
Event Details
12:00 – 12:30 Camilla Pegoraro 12:30 – 13:00 Francesca de Angelis
Event Details
12:00 – 12:30 Camilla Pegoraro
12:30 – 13:00 Francesca de Angelis
Time
(Friday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
Time
27 (Monday) 09:30 - 28 (Tuesday) 17:00
Organizer
Event Details
“The new reality of the Mediterranean: accelerating impacts of climate change” Speaker: Samira Khodayar Pardo Institution: Head of the Meteorology and Climatology Department of the Mediterranean Center for Environmental Studies (CEAM),
Event Details
“The new reality of the Mediterranean: accelerating impacts of climate change”
Speaker: Samira Khodayar Pardo
Institution: Head of the Meteorology and Climatology Department of the Mediterranean Center for Environmental Studies (CEAM), Valencia, Spain, and Distinguished Researcher of Excellence (CIDEGENT-GVA)
Place: CIPF conference room
The Mediterranean basin is a hot spot for climate change warming up to 1.5 times faster than the rest of the world with the Mediterranean Sea warming three times more than the oceans (MedECC 2020). A consensus exists about the magnification of extreme phenomena in the area under climate change (IPCC 2021). In fact, several types of risks currently affect and will continue affecting the region severely, from more frequent extreme weather events such as heat waves, droughts, or floods, to increasing sea surface temperature and coastal erosion due to rising sea levels. The impacts affect the region’s ecosystems, economic activities, and, ultimately, human health. In addition, the effects also spread like “cascades” that generate multiple impacts in all socioeconomic sectors. Current change and future scenarios consistently point to significant and increasing risks during the coming decades in most impact domains such as water and energy resources, ecosystems, agriculture and food, fishery, health, and human security.
The impacts of climate change have accelerated on the Mediterranean coast of the Iberian Peninsula in the last decades. In this presentation, we will discuss this acceleration based on observations of the notorious and progressive rise in atmospheric and sea surface temperature and the generalized reduction of mean accumulated precipitation in the region. In this context, the magnification of extreme weather phenomena in the region will be described in detail focusing on the spatio-temporal evolution of terrestrial and marine heat waves, as well as extreme precipitation in the autumn period.
Time
(Friday) 12:30 - 13:30
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
21apr12:0013:00SEMINAR: Paula Doria / Javier González Fernández
Event Details
12:00 – 12:30 Paula Doria 12:30 – 13:00 Javier González Fernández
Event Details
12:00 – 12:30 Paula Doria
12:30 – 13:00 Javier González Fernández
Time
(Friday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
28apr12:3013:30FBR: Amanda Sferruzzi-Perri
Event Details
Speaker: Amanda Sferruzzi-Perri Institution: Physiology, Development and Neuroscience Department, Centre for Trophoblast Research, University of Cambridge. United Kingdom. Place: CIPF conference room Abstract:
Event Details
Speaker: Amanda Sferruzzi-Perri
Institution: Physiology, Development and Neuroscience Department, Centre for Trophoblast Research, University of Cambridge. United Kingdom.
Place: CIPF conference room
Abstract:
Time
(Friday) 12:30 - 13:30
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
05may12:3013:30FBR: Jochen Prehn
Event Details
Speaker: Jochen Prehn Institution: Physiology and Medical Physics Department, Centre for Systems Medicine, Royal College of Surgeons in Ireland. Dublin, Ireland Place: CIPF conference room Abstract:
Event Details
Speaker: Jochen Prehn
Institution: Physiology and Medical Physics Department, Centre for Systems Medicine, Royal College of Surgeons in Ireland. Dublin, Ireland
Place: CIPF conference room
Abstract:
Time
(Friday) 12:30 - 13:30
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
26may12:0013:00SEMINAR: Milagros Buffa / María Ibáñez
Event Details
12:00 – 12:30 Milagros Buffa 12:30 – 13:00 María Ibáñez
Event Details
12:00 – 12:30 Milagros Buffa
12:30 – 13:00 María Ibáñez
Time
(Friday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
09jun12:0013:00SEMINAR: María Ángeles Juanes / Marcos Agustina Hernández
Event Details
12:00 – 12:30 María Ángeles Juanes 12:30 – 13:00 Marcos Agustina Hernández
Event Details
12:00 – 12:30 María Ángeles Juanes
12:30 – 13:00 Marcos Agustina Hernández
Time
(Friday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
30jun12:0013:00SEMINAR: Paula Hernández Calderón / Luke Noon
Event Details
12:00 – 12:30 Paula Hernández Calderón 12:30 – 13:00 Luke Noon
Event Details
12:00 – 12:30 Paula Hernández Calderón
12:30 – 13:00 Luke Noon
Time
(Friday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
january 2023
20jan12:3013:30FBR: Toby LawrenceOntogeny and function of tumour-associated macrophages
Event Details
Speaker: Toby Lawrence Institution: Centre for Inflammation Biology and Cancer Immunology, King’s College London. London, United Kingdom Place: CIPF conference room Title: Ontogeny and function of tumour-associated macrophages Abstract:
Event Details
Speaker: Toby Lawrence
Institution: Centre for Inflammation Biology and Cancer Immunology, King’s College London. London, United Kingdom
Place: CIPF conference room
Title: Ontogeny and function of tumour-associated macrophages
Abstract:
There is now a wealth of clinical and experimental evidence that strongly links the accumulation of tumour-associated macrophages (TAM) with cancer progression, invasion and metastasis. In the vast majority of published studies increased numbers of TAM correlate with poor prognosis, but in some cases, specific TAM subsets have been associated with beneficial outcomes – which may reflect their roles in orchestrating protective immune responses. In fact, recent studies using paired single cell analysis by mass cytometry and RNA sequencing, have revealed an unprecedented level of diversity among TAM in human cancer. But will still understand little about the significance of TAM heterogeneity and the functions of different TAM subsets in disease progression, which is critical to design more targeted therapies.
We have characterised the ontogeny and function of different TAM subsets in experimental models of cancer. We have demonstrated that a subset of monocyte-derived macrophages (MDM) that express the scavenger receptor CD163, exert profound immune-suppressive functions and prevent the mobilisation of anti-tumour immune responses. In other studies, we have characterised subsets of tissue-resident macrophages of embryonic origins (TRM), which specifically promote the invasive activity of disseminated cancer cells and the metastatic spread of disease. Our studies suggest monocyte-derived and tissue-resident TAM subsets have divergent functions in tumour progression and we are actively exploring the molecular basis of TAM diversity.
Time
(Friday) 12:30 - 13:30
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
Event Details
Thesis Title: The inflammatory tumor microenvironment as a target in the design of nanoconjugates for the treatment of advanced breast cancer Author: Paula Soriano Teruel PhD. Supervisors: Mar Orzáez, Mª Jesús Vicent
Event Details
Thesis Title: The inflammatory tumor microenvironment as a target in the design of nanoconjugates for the treatment of advanced breast cancer
Author: Paula Soriano Teruel
PhD. Supervisors: Mar Orzáez, Mª Jesús Vicent
Summary:
This thesis focuses on the evaluation of a novel inflammasome inhibitor (MM01) as a chemical tool to study the role of the inflammasome in models of inflammation and cancer.
In this work we delineate a novel mechanism of action for MM01, a recently identified modulator of inflammasome activity. We demonstrate that MM01 disrupts ASC oligomerization, a process associated with the activity of various inflammasomes, and inhibits downstream IL-1β release and death by pyroptosis in various cellular and in vivo models of inflammation. We have employed MM01, to study the role of the inflammasome in tumor progression in different breast cancer models both in vitro and in vivo, and developed a synthetic strategy to obtain a novel nanomedicine that improved the solubility and tumor-targeting capabilities of MM01 in breast cancer.
Time
(Friday) 12:00 - 14:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
31jan11:3013:30Jornada Epiforward: la voz de la epilepsia
Time
(Tuesday) 11:30 - 13:30
Organizer
february, 2023
upcoming events
take note
january 2023
20jan12:3013:30FBR: Toby LawrenceOntogeny and function of tumour-associated macrophages
Event Details
Speaker: Toby Lawrence Institution: Centre for Inflammation Biology and Cancer Immunology, King’s College London. London, United Kingdom Place: CIPF conference room Title: Ontogeny and function of tumour-associated macrophages Abstract:
Event Details
Speaker: Toby Lawrence
Institution: Centre for Inflammation Biology and Cancer Immunology, King’s College London. London, United Kingdom
Place: CIPF conference room
Title: Ontogeny and function of tumour-associated macrophages
Abstract:
There is now a wealth of clinical and experimental evidence that strongly links the accumulation of tumour-associated macrophages (TAM) with cancer progression, invasion and metastasis. In the vast majority of published studies increased numbers of TAM correlate with poor prognosis, but in some cases, specific TAM subsets have been associated with beneficial outcomes – which may reflect their roles in orchestrating protective immune responses. In fact, recent studies using paired single cell analysis by mass cytometry and RNA sequencing, have revealed an unprecedented level of diversity among TAM in human cancer. But will still understand little about the significance of TAM heterogeneity and the functions of different TAM subsets in disease progression, which is critical to design more targeted therapies.
We have characterised the ontogeny and function of different TAM subsets in experimental models of cancer. We have demonstrated that a subset of monocyte-derived macrophages (MDM) that express the scavenger receptor CD163, exert profound immune-suppressive functions and prevent the mobilisation of anti-tumour immune responses. In other studies, we have characterised subsets of tissue-resident macrophages of embryonic origins (TRM), which specifically promote the invasive activity of disseminated cancer cells and the metastatic spread of disease. Our studies suggest monocyte-derived and tissue-resident TAM subsets have divergent functions in tumour progression and we are actively exploring the molecular basis of TAM diversity.
Time
(Friday) 12:30 - 13:30
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
Event Details
Thesis Title: The inflammatory tumor microenvironment as a target in the design of nanoconjugates for the treatment of advanced breast cancer Author: Paula Soriano Teruel PhD. Supervisors: Mar Orzáez, Mª Jesús Vicent
Event Details
Thesis Title: The inflammatory tumor microenvironment as a target in the design of nanoconjugates for the treatment of advanced breast cancer
Author: Paula Soriano Teruel
PhD. Supervisors: Mar Orzáez, Mª Jesús Vicent
Summary:
This thesis focuses on the evaluation of a novel inflammasome inhibitor (MM01) as a chemical tool to study the role of the inflammasome in models of inflammation and cancer.
In this work we delineate a novel mechanism of action for MM01, a recently identified modulator of inflammasome activity. We demonstrate that MM01 disrupts ASC oligomerization, a process associated with the activity of various inflammasomes, and inhibits downstream IL-1β release and death by pyroptosis in various cellular and in vivo models of inflammation. We have employed MM01, to study the role of the inflammasome in tumor progression in different breast cancer models both in vitro and in vivo, and developed a synthetic strategy to obtain a novel nanomedicine that improved the solubility and tumor-targeting capabilities of MM01 in breast cancer.
Time
(Friday) 12:00 - 14:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
31jan11:3013:30Jornada Epiforward: la voz de la epilepsia
Time
(Tuesday) 11:30 - 13:30
Organizer
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