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01jun00:0001dec00:00COURSE: Precision OncologyFrom the laboratory to the clinic
Time
June 1 (Thursday) 00:00 - December 1 (Friday) 00:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
06nov01decCOURSE: Flow Cytometry: Technical Bases 2nd Edition
Time
November 6 (Monday) 15:00 - December 1 (Friday) 19:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
12dec10:3012:00Estudio de la inflamación en distrofias heredetarias de la retina
Event Details
Event Details
Time
(Tuesday) 10:30 - 12:00
Organizer
14dec12:0013:00SEMINAR: Alihamze Fathinajabadi
Event Details
12:00 – 12:30 Alihamze Fathinajafabadi Multilevel action of AP-1 transcription factors in lung tumor microenvironment Abstract: AP-1, a group of dimeric transcriptional complexes composed of combinations of JUN, FOS,
Event Details
12:00 – 12:30 Alihamze Fathinajafabadi
Multilevel action of AP-1 transcription factors in lung tumor microenvironment
Abstract: AP-1, a group of dimeric transcriptional complexes composed of combinations of JUN, FOS, ATF and MAF family members, plays a central role in the physiology of both individual cells and the entire organism, including embryo development and tissue homeostasis. It is involved in many cellular processes such as differentiation, proliferation, and apoptosis. Dysregulation of AP-1 protein levels and their post-translationally activated states have been implicated in various pathologies, notably tumor development. Lung cancer, particularly lung adenocarcinoma, exhibits significant involvement of AP-1 members, with the overexpression of FOSL1 and FOSL2 associated with adverse patient survival.
In our laboratory, we are investigating the multilevel actions of AP-1 activity in the lung adenocarcinoma microenvironment. Employing a combination of microscopic analysis of patient samples and in vitro approaches using related cell lines, we are assessing the protein expression patterns and intracellular localization of FRA1 (encoded by FOSL1), FRA2 (encoded by FOSL2), and JUNB. Preliminary results reveal a distinct expression pattern for these three proteins, dependent on the specific cell type within the tumor tissue. This observed differential distribution suggests a spatial-temporal coordination orchestrated by FRA1, FRA2, and JUNB between tumoral cells and specific subtypes of resident leukocytes in the tumor microenvironment, such as TANs (Tumor-Associated Neutrophils). Consequently, our findings propose a multilevel control exerted by specific AP-1 members within the tumoral context, shedding light on the intricate interplay within the lung adenocarcinoma microenvironment.
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
15dec13:0014:00FBR: Prof. Simon Matoori Repurposing drug delivery systems for diagnostics
Event Details
Repurposing drug delivery systems for diagnostics Speaker: Prof. Joern Dengjel Institution: Faculté de Pharmacie, Université de Montréal, Montréal, Canada Place: Jerónimo Forteza conference room, CIPF Abstract: In the last
Event Details
Repurposing drug delivery systems for diagnostics
Speaker: Prof. Joern Dengjel
Institution: Faculté de Pharmacie, Université de Montréal, Montréal, Canada
Place: Jerónimo Forteza conference room, CIPF
Abstract:
In the last two decades, a number of drug delivery systems were repurposed for diagnostic applications. Traditional uses of diagnostic delivery systems are nanocarriers of diagnostic cargo (e.g., contrast agents) with controlled release kinetics or active targeting properties. In this seminar, I will demonstrate how established delivery systems can be used for diagnostics in less conventional ways. First, I will present the development of an enzyme-loaded vesicular reaction compartment for the quantification of lactate in whole blood. Isolating the lactate-sensing reaction in the liposomal lumen allowed this reaction to occur in whole blood as interfering substances were incapable of crossing the membrane. This vesicular reaction compartment forms the basis of a novel blood lactate assay for bedside use in sepsis. The fluorescence assay was tested in fresh human blood in an Institutional Review Board-approved study and successfully combined with a portable fluorometer. This system highlighted how the selectively permeable membrane of liposomes could be utilized to isolate an enzymatic reaction in order to enable it in a prohibiting matrix. Second, I will present the development of a series of novel non-releasing hydrogels for diagnostic applications. Hydrogels are widely used in tissue engineering and drug delivery, and their localization is tied to their function. As means for hydrogel localization in the body are limited, we developed a new and broadly applicable method to track hydrogels by encapsulating a clinically used oil-based contrast agent. This non-releasing system was visualized in mice using computed tomography. Another example of a non-releasing hydrogel is a pH-sensing diagnostic wound dressing for chronic wounds. Hydrogels loaded with pH-sensitive fluorescent microparticles were developed and sensed the pH in a clinically relevant range on dorsal mouse wounds. The dye was highly retained on microparticles in the presence of biological fluids to minimize the risk of wound exposure to the dye. These liposomal and hydrogel systems highlight the high versatility and usefulness of drug delivery systems for diagnostic applications.
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Friday) 13:00 - 14:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
11apr12:0013:00SEMINAR: Edna Ripollés / Jesús Alejandro Alzate
Event Details
12:00 – 12:30 Edna Ripollés Title Abstract 12:30 – 13:00 Jesús Alejandro Alzate Title Abstract
Event Details
12:00 – 12:30 Edna Ripollés
Title
Abstract
12:30 – 13:00 Jesús Alejandro Alzate
Title
Abstract
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
01jun00:0001dec00:00COURSE: Precision OncologyFrom the laboratory to the clinic
Time
June 1 (Thursday) 00:00 - December 1 (Friday) 00:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
06nov01decCOURSE: Flow Cytometry: Technical Bases 2nd Edition
Time
November 6 (Monday) 15:00 - December 1 (Friday) 19:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
12dec10:3012:00Estudio de la inflamación en distrofias heredetarias de la retina
Event Details
Event Details
Time
(Tuesday) 10:30 - 12:00
Organizer
14dec12:0013:00SEMINAR: Alihamze Fathinajabadi
Event Details
12:00 – 12:30 Alihamze Fathinajafabadi Multilevel action of AP-1 transcription factors in lung tumor microenvironment Abstract: AP-1, a group of dimeric transcriptional complexes composed of combinations of JUN, FOS,
Event Details
12:00 – 12:30 Alihamze Fathinajafabadi
Multilevel action of AP-1 transcription factors in lung tumor microenvironment
Abstract: AP-1, a group of dimeric transcriptional complexes composed of combinations of JUN, FOS, ATF and MAF family members, plays a central role in the physiology of both individual cells and the entire organism, including embryo development and tissue homeostasis. It is involved in many cellular processes such as differentiation, proliferation, and apoptosis. Dysregulation of AP-1 protein levels and their post-translationally activated states have been implicated in various pathologies, notably tumor development. Lung cancer, particularly lung adenocarcinoma, exhibits significant involvement of AP-1 members, with the overexpression of FOSL1 and FOSL2 associated with adverse patient survival.
In our laboratory, we are investigating the multilevel actions of AP-1 activity in the lung adenocarcinoma microenvironment. Employing a combination of microscopic analysis of patient samples and in vitro approaches using related cell lines, we are assessing the protein expression patterns and intracellular localization of FRA1 (encoded by FOSL1), FRA2 (encoded by FOSL2), and JUNB. Preliminary results reveal a distinct expression pattern for these three proteins, dependent on the specific cell type within the tumor tissue. This observed differential distribution suggests a spatial-temporal coordination orchestrated by FRA1, FRA2, and JUNB between tumoral cells and specific subtypes of resident leukocytes in the tumor microenvironment, such as TANs (Tumor-Associated Neutrophils). Consequently, our findings propose a multilevel control exerted by specific AP-1 members within the tumoral context, shedding light on the intricate interplay within the lung adenocarcinoma microenvironment.
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
15dec13:0014:00FBR: Prof. Simon Matoori Repurposing drug delivery systems for diagnostics
Event Details
Repurposing drug delivery systems for diagnostics Speaker: Prof. Joern Dengjel Institution: Faculté de Pharmacie, Université de Montréal, Montréal, Canada Place: Jerónimo Forteza conference room, CIPF Abstract: In the last
Event Details
Repurposing drug delivery systems for diagnostics
Speaker: Prof. Joern Dengjel
Institution: Faculté de Pharmacie, Université de Montréal, Montréal, Canada
Place: Jerónimo Forteza conference room, CIPF
Abstract:
In the last two decades, a number of drug delivery systems were repurposed for diagnostic applications. Traditional uses of diagnostic delivery systems are nanocarriers of diagnostic cargo (e.g., contrast agents) with controlled release kinetics or active targeting properties. In this seminar, I will demonstrate how established delivery systems can be used for diagnostics in less conventional ways. First, I will present the development of an enzyme-loaded vesicular reaction compartment for the quantification of lactate in whole blood. Isolating the lactate-sensing reaction in the liposomal lumen allowed this reaction to occur in whole blood as interfering substances were incapable of crossing the membrane. This vesicular reaction compartment forms the basis of a novel blood lactate assay for bedside use in sepsis. The fluorescence assay was tested in fresh human blood in an Institutional Review Board-approved study and successfully combined with a portable fluorometer. This system highlighted how the selectively permeable membrane of liposomes could be utilized to isolate an enzymatic reaction in order to enable it in a prohibiting matrix. Second, I will present the development of a series of novel non-releasing hydrogels for diagnostic applications. Hydrogels are widely used in tissue engineering and drug delivery, and their localization is tied to their function. As means for hydrogel localization in the body are limited, we developed a new and broadly applicable method to track hydrogels by encapsulating a clinically used oil-based contrast agent. This non-releasing system was visualized in mice using computed tomography. Another example of a non-releasing hydrogel is a pH-sensing diagnostic wound dressing for chronic wounds. Hydrogels loaded with pH-sensitive fluorescent microparticles were developed and sensed the pH in a clinically relevant range on dorsal mouse wounds. The dye was highly retained on microparticles in the presence of biological fluids to minimize the risk of wound exposure to the dye. These liposomal and hydrogel systems highlight the high versatility and usefulness of drug delivery systems for diagnostic applications.
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Friday) 13:00 - 14:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
01jun00:0001dec00:00COURSE: Precision OncologyFrom the laboratory to the clinic
Time
June 1 (Thursday) 00:00 - December 1 (Friday) 00:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
06nov01decCOURSE: Flow Cytometry: Technical Bases 2nd Edition
Time
November 6 (Monday) 15:00 - December 1 (Friday) 19:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
12dec10:3012:00Estudio de la inflamación en distrofias heredetarias de la retina
Event Details
Event Details
Time
(Tuesday) 10:30 - 12:00
Organizer
14dec12:0013:00SEMINAR: Alihamze Fathinajabadi
Event Details
12:00 – 12:30 Alihamze Fathinajafabadi Multilevel action of AP-1 transcription factors in lung tumor microenvironment Abstract: AP-1, a group of dimeric transcriptional complexes composed of combinations of JUN, FOS,
Event Details
12:00 – 12:30 Alihamze Fathinajafabadi
Multilevel action of AP-1 transcription factors in lung tumor microenvironment
Abstract: AP-1, a group of dimeric transcriptional complexes composed of combinations of JUN, FOS, ATF and MAF family members, plays a central role in the physiology of both individual cells and the entire organism, including embryo development and tissue homeostasis. It is involved in many cellular processes such as differentiation, proliferation, and apoptosis. Dysregulation of AP-1 protein levels and their post-translationally activated states have been implicated in various pathologies, notably tumor development. Lung cancer, particularly lung adenocarcinoma, exhibits significant involvement of AP-1 members, with the overexpression of FOSL1 and FOSL2 associated with adverse patient survival.
In our laboratory, we are investigating the multilevel actions of AP-1 activity in the lung adenocarcinoma microenvironment. Employing a combination of microscopic analysis of patient samples and in vitro approaches using related cell lines, we are assessing the protein expression patterns and intracellular localization of FRA1 (encoded by FOSL1), FRA2 (encoded by FOSL2), and JUNB. Preliminary results reveal a distinct expression pattern for these three proteins, dependent on the specific cell type within the tumor tissue. This observed differential distribution suggests a spatial-temporal coordination orchestrated by FRA1, FRA2, and JUNB between tumoral cells and specific subtypes of resident leukocytes in the tumor microenvironment, such as TANs (Tumor-Associated Neutrophils). Consequently, our findings propose a multilevel control exerted by specific AP-1 members within the tumoral context, shedding light on the intricate interplay within the lung adenocarcinoma microenvironment.
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
15dec13:0014:00FBR: Prof. Simon Matoori Repurposing drug delivery systems for diagnostics
Event Details
Repurposing drug delivery systems for diagnostics Speaker: Prof. Joern Dengjel Institution: Faculté de Pharmacie, Université de Montréal, Montréal, Canada Place: Jerónimo Forteza conference room, CIPF Abstract: In the last
Event Details
Repurposing drug delivery systems for diagnostics
Speaker: Prof. Joern Dengjel
Institution: Faculté de Pharmacie, Université de Montréal, Montréal, Canada
Place: Jerónimo Forteza conference room, CIPF
Abstract:
In the last two decades, a number of drug delivery systems were repurposed for diagnostic applications. Traditional uses of diagnostic delivery systems are nanocarriers of diagnostic cargo (e.g., contrast agents) with controlled release kinetics or active targeting properties. In this seminar, I will demonstrate how established delivery systems can be used for diagnostics in less conventional ways. First, I will present the development of an enzyme-loaded vesicular reaction compartment for the quantification of lactate in whole blood. Isolating the lactate-sensing reaction in the liposomal lumen allowed this reaction to occur in whole blood as interfering substances were incapable of crossing the membrane. This vesicular reaction compartment forms the basis of a novel blood lactate assay for bedside use in sepsis. The fluorescence assay was tested in fresh human blood in an Institutional Review Board-approved study and successfully combined with a portable fluorometer. This system highlighted how the selectively permeable membrane of liposomes could be utilized to isolate an enzymatic reaction in order to enable it in a prohibiting matrix. Second, I will present the development of a series of novel non-releasing hydrogels for diagnostic applications. Hydrogels are widely used in tissue engineering and drug delivery, and their localization is tied to their function. As means for hydrogel localization in the body are limited, we developed a new and broadly applicable method to track hydrogels by encapsulating a clinically used oil-based contrast agent. This non-releasing system was visualized in mice using computed tomography. Another example of a non-releasing hydrogel is a pH-sensing diagnostic wound dressing for chronic wounds. Hydrogels loaded with pH-sensitive fluorescent microparticles were developed and sensed the pH in a clinically relevant range on dorsal mouse wounds. The dye was highly retained on microparticles in the presence of biological fluids to minimize the risk of wound exposure to the dye. These liposomal and hydrogel systems highlight the high versatility and usefulness of drug delivery systems for diagnostic applications.
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Friday) 13:00 - 14:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
18jan12:0013:00SEMINAR: Javier Martínez / Carlos Camps
Event Details
12:00 – 12:30 Javier Martínez Latorre Title Abstract 12:30 – 13:00 Carlos Camps Title Abstract
Event Details
12:00 – 12:30 Javier Martínez Latorre
Title
Abstract
12:30 – 13:00 Carlos Camps
Title
Abstract
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
22feb12:0013:00SEMINAR: Verónica Llorens / Jose Luís López
Event Details
12:00 – 12:30 Verónica Llorens Title Abstract 12:30 – 13:00 Jose Luís López Title Abstract
Event Details
12:00 – 12:30 Verónica Llorens
Title
Abstract
12:30 – 13:00 Jose Luís López
Title
Abstract
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
11apr12:0013:00SEMINAR: Edna Ripollés / Jesús Alejandro Alzate
Event Details
12:00 – 12:30 Edna Ripollés Title Abstract 12:30 – 13:00 Jesús Alejandro Alzate Title Abstract
Event Details
12:00 – 12:30 Edna Ripollés
Title
Abstract
12:30 – 13:00 Jesús Alejandro Alzate
Title
Abstract
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
16may12:0013:00SEMINAR: To be confirmed / Regina Rodrigo
Event Details
12:00 – 12:30 To be confirmed Abstract 12:30 – 13:00 Regina Rodrigo Title Abstract
Event Details
12:00 – 12:30 To be confirmed
Abstract
12:30 – 13:00 Regina Rodrigo
Title
Abstract
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
20jun12:0013:00SEMINAR: Mª del Mar Sánchez / Mª Ángeles Juanes
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín Abstract 12:30 – 13:00 Mª Ángeles Juanes Title Abstract
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín
Abstract
12:30 – 13:00 Mª Ángeles Juanes
Title
Abstract
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
december 2023
01jun00:0001dec00:00COURSE: Precision OncologyFrom the laboratory to the clinic
Time
June 1 (Thursday) 00:00 - December 1 (Friday) 00:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
06nov01decCOURSE: Flow Cytometry: Technical Bases 2nd Edition
Time
November 6 (Monday) 15:00 - December 1 (Friday) 19:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
12dec10:3012:00Estudio de la inflamación en distrofias heredetarias de la retina
Event Details
Event Details
Time
(Tuesday) 10:30 - 12:00
Organizer
january, 2024
upcoming events
take note
december 2023
01jun00:0001dec00:00COURSE: Precision OncologyFrom the laboratory to the clinic
Time
June 1 (Thursday) 00:00 - December 1 (Friday) 00:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
06nov01decCOURSE: Flow Cytometry: Technical Bases 2nd Edition
Time
November 6 (Monday) 15:00 - December 1 (Friday) 19:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
12dec10:3012:00Estudio de la inflamación en distrofias heredetarias de la retina
Event Details
Event Details
Time
(Tuesday) 10:30 - 12:00
Organizer
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