The molecular basis of cell-to-cell communication between hosts and intestinal microbiota, and their impact the development of metabolic diseases.
The laboratory for Host-Microbe Interactions in Metabolic Health aims scientific research on the molecular basis of the cell-to-cell communication between intestinal microbiota and the host, and the impact of its impairment in the development of metabolic diseases. The human-associated microbiota research (comprising bacteria, viruses, fungi, unicellular prokaryotes, archaea, etc.), and especially that inhabiting the gastrointestinal tract has established solid knowledge on the symbiotic relationships between these microorganisms and us across our evolutionary history and industrialization. Furthermore, microbiota research applied to biomedicine has evidenced the large impact that our microbes have in our health. Nutrients, metabolites, and proteins exchange between intestinal microbiota and our cells are fundamental to regulate several physiological processes governing our body. Recent advances in microbiota research strongly suggest that impairment in such cell-to-cell molecular communications contribute, and could be the basis, to development of some human diseases including those diet-associated (e.g. obesity, metabolic syndrome, type-2 diabetes, celiac disease, liver disease, among others), behavioural (depression), and cognitive impairment (Alzheimer’s disease).
Get to know us better
The people who make it all possible
Alfonso Benitez Paez
Paula Hernández Calderón
Our scientific contributions
Assessment of human microbiota stability across longitudinal samples using iteratively growing-partitioned clustering
P. SANCHEZ-SANCHEZ, F. SANTONJA and A. BENITEZ-PAEZ
BRIEFINGS IN BIOINFORMATICS, 2022 Mar,  DOI:  10.1093/bib/bbac055,  Vol. 23,  pag.
Species- and strain-level assessment using rrn long-amplicons suggests donor's influence on gut microbial transference via fecal transplants in metabolic syndrome subjects.
Benítez-Páez A, Hartstra AV, Nieuwdorp M and Sanz Y
Gut Microbes, 2022 Jan,  DOI:  10.1080/19490976.2022.2078621,  Vol. 14,  pag. 2078621-2078621
Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men
A. BENITEZ-PAEZ, A. HESS, S. KRAUTBAUER, G. LIEBISCH, L. CHRISTENSEN, M. HJORTH, T. LARSEN, Y. SANZ and MyNewGut Consortium
MOLECULAR NUTRITION & FOOD RESEARCH, 2021 Apr,  DOI:  10.1002/mnfr.202000996,  Vol. 65,  pag.
Microbial enterotypes beyond genus level: Bacteroides species as a predictive biomarker for weight change upon controlled intervention with arabinoxylan oligosaccharides in overweight subjects
L. CHRISTENSEN, C. SORENSEN, F. WOHLK, L. KJOLBAEK, A. ASTRUP, Y. SANZ, M. HJORTH and A. BENITEZ-PAEZ
Gut Microbes, 2020 Nov,  DOI:  10.1080/19490976.2020.1847627,  Vol. 12,  pag. 1847627-1847627
Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis.
Agudelo-Ochoa GM, Valdés-Duque BE, Giraldo-Giraldo NA, Jaillier-Ramírez AM, Giraldo-Villa A, Acevedo-Castaño I, Yepes-Molina MA, Barbosa-Barbosa J and Benítez-Paéz A
Gut Microbes, 2020 Jan,  DOI:  10.1080/19490976.2019.1707610,  Vol. ,  pag. 1-16