The molecular basis of cell-to-cell communication between hosts and intestinal microbiota, and their impact the development of metabolic diseases.
The laboratory for Host-Microbe Interactions in Metabolic Health aims scientific research on the molecular basis of the cell-to-cell communication between intestinal microbiota and the host, and the impact of its impairment in the development of metabolic diseases. The human-associated microbiota research (comprising bacteria, viruses, fungi, unicellular prokaryotes, archaea, etc.), and especially that inhabiting the gastrointestinal tract has established solid knowledge on the symbiotic relationships between these microorganisms and us across our evolutionary history and industrialization. Furthermore, microbiota research applied to biomedicine has evidenced the large impact that our microbes have in our health. Nutrients, metabolites, and proteins exchange between intestinal microbiota and our cells are fundamental to regulate several physiological processes governing our body. Recent advances in microbiota research strongly suggest that impairment in such cell-to-cell molecular communications contribute, and could be the basis, to development of some human diseases including those diet-associated (e.g. obesity, metabolic syndrome, type-2 diabetes, celiac disease, liver disease, among others), behavioural (depression), and cognitive impairment (Alzheimer’s disease).
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The people who make it all possible
Alfonso Benitez Paez
Our scientific contributions
Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men
A. BENITEZ-PAEZ, A. HESS, S. KRAUTBAUER, G. LIEBISCH, L. CHRISTENSEN, M. HJORTH, T. LARSEN, Y. SANZ and MyNewGut Consortium
MOLECULAR NUTRITION & FOOD RESEARCH, 2021 Apr,  DOI:  10.1002/mnfr.202000996,  Vol. 65,  pag.
Microbial enterotypes beyond genus level: Bacteroides species as a predictive biomarker for weight change upon controlled intervention with arabinoxylan oligosaccharides in overweight subjects
L. CHRISTENSEN, C. SORENSEN, F. WOHLK, L. KJOLBAEK, A. ASTRUP, Y. SANZ, M. HJORTH and A. BENITEZ-PAEZ
Gut Microbes, 2020 Nov,  DOI:  10.1080/19490976.2020.1847627,  Vol. 12,  pag. 1847627-1847627
Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening.
Benítez-Páez A, Gómez Del Pugar EM, López-Almela I, Moya-Pérez Á, Codoñer-Franch P and Sanz Y
mSystems, 2020 Mar,  DOI:  10.1128/mSystems.00857-19,  Vol. 5,  pag.
Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis.
Agudelo-Ochoa GM, Valdés-Duque BE, Giraldo-Giraldo NA, Jaillier-Ramírez AM, Giraldo-Villa A, Acevedo-Castaño I, Yepes-Molina MA, Barbosa-Barbosa J and Benítez-Paéz A
Gut Microbes, 2020 Jan,  DOI:  10.1080/19490976.2019.1707610,  Vol. ,  pag. 1-16
Multi-locus and long amplicon sequencing approach to study microbial diversity at species level using the MinION™ portable nanopore sequencer.
Benítez-Páez A and Sanz Y
GigaScience, 2017 Jul,  DOI:  10.1093/gigascience/gix043,  Vol. 6,  pag. 1-12