We are interested in how different molecular and cellular regulatory mechanisms control inflammatory processes in pathological conditions.
The major focus of our research is the regulation of immune responses in the contexts of infection, autoimmune disease, and cancer. This is because inflammation plays a fundamental physiological role in all of these processes. We are particularly interested in how different molecular and cellular regulatory mechanisms control inflammatory processes in pathological conditions. Therefore, we are trying to understand the links between inflammation and cancer, and inflammation and metabolism, with a particular emphasis on how metabolism governs this process.
Our work currently focuses on the role of metabolism in regulating T helper cell development and function. In particular, we are using a wide variety of in vivo and in vitro approaches which combine advanced genetic murine modeling and immunological techniques. We hope to use these tools to address some fundamental questions in immune cell metabolism and its impact on protective immunity against infection, autoimmunity, and cancer.
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The people who make it all possible
Enric Esplugues Artola
Salvador Meseguer Llopis
Maria Paz Rubio Rodriguez
Our scientific contributions
T H 17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine.
Pascual-Reguant A, Bayat Sarmadi J, Baumann C, Noster R, Cirera-Salinas D, Curato C, Pelczar P, Huber S, Zielinski CE, Löhning M, Hauser AE and Esplugues E
Mucosal Immunology, 2017 Nov,  DOI:  10.1038/mi.2017.5,  Vol. 10,  pag. 1431-1442
Apoptosis in response to microbial infection induces autoreactive TH17 cells.
Campisi L, Barbet G, Ding Y, Esplugues E, Flavell RA and Blander JM
NATURE IMMUNOLOGY, 2016 Sep,  DOI:  10.1038/ni.3512,  Vol. 17,  pag. 1084-1092
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
Gagliani N, Amezcua Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva RS, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, Cotton MJ, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S and Flavell RA
NATURE, 2015 Jul,  DOI:  10.1038/nature14452,  Vol. 523,  pag. 221-225
Control of TH17 cells occurs in the small intestine.
Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC and Flavell RA
NATURE, 2011 Jul,  DOI:  10.1038/nature10228,  Vol. 475,  pag. 514-518
Th17 cells express interleukin-10 receptor and are controlled by Foxp3? and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.
Huber S, Gagliani N, Esplugues E, O'Connor W, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M and Flavell RA
IMMUNITY, 2011 Apr,  DOI:  10.1016/j.immuni.2011.01.020,  Vol. 34,  pag. 554-565