IDENTIFICATION OF THE MECHANISMS RESPONSIBLE FOR THE FORMATION OF MEMORY IN NORMAL CONDITIONS AND IN NEURODEGENERATIVE DISEASES.
Neural plasticity is defined as the ability of neuronal circuits to undergo functional changes that are decisive to our adaptive behavior. The main objective of our laboratory is to identify neuronal plasticity mechanisms involved in memory formation under normal conditions and in animal models of neurodegenerative diseases such as Alzheimer’s disease. To do this, we use a sophisticated combination of electrophysiology and molecular biology techniques, together with learning and memory tasks in rodents.
The results of our line of research will
- Increase our understanding of the neurobiological basis of memory formation in mammals.
- Enable the identification of the molecular mechanisms involved in cognitive impairment such as memory loss.
- Allow us to develop approaches that can be used to manipulate neuronal plasticity in order to facilitate memory formation and cognitive performance in the context of neurodegenerative pathologies.
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Our scientific contributions
Developmental Disruption of Erbb4 in Pet1 + Neurons Impairs Serotonergic Sub-System Connectivity and Memory Formation.
Barettino C, Ballesteros-Gonzalez Á, Aylón A, Soler-Sanchis X, Ortí L, Díaz S, Reillo I, García-García F, Iborra FJ, Lai C, Dehorter N, Leinekugel X, Flames N and Del Pino I
Frontiers in Cell and Developmental Biology, 2021 Dec, DOI: 10.3389/fcell.2021.770458, Vol. 9, pag. 770458-770458
COUP-TFI/Nr2f1 Orchestrates Intrinsic Neuronal Activity during Development of the Somatosensory Cortex.
Del Pino I, Tocco C, Magrinelli E, Marcantoni A, Ferraguto C, Tomagra G, Bertacchi M, Alfano C, Leinekugel X, Frick A and Studer M
CEREBRAL CORTEX, 2020 Nov, DOI: 10.1093/cercor/bhaa137, Vol. 30, pag. 5667-5685
Neural circuit dysfunction in mouse models of neurodevelopmental disorders.
Del Pino I, Rico B and Marín O
CURRENT OPINION IN NEUROBIOLOGY, 2018 Feb, DOI: 10.1016/j.conb.2017.12.013, Vol. 48, pag. 174-182
Abnormal wiring of CCK + basket cells disrupts spatial information coding.
Del Pino I, Brotons-Mas JR, Marques-Smith A, Marighetto A, Frick A, Marín O and Rico B
NATURE NEUROSCIENCE, 2017 Jun, DOI: 10.1038/nn.4544, Vol. 20, pag. 784-792
Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch.
Dehorter N, Ciceri G, Bartolini G, Lim L, del Pino I and Marín O
SCIENCE, 2015 Sep, DOI: 10.1126/science.aab3415, Vol. 349, pag. 1216-1220
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