THE JOINT UNIT ON NEUROLOGICAL IMPAIRMENT CIPF-INCLIVA PERFORMS BASIC AND TRANSLATIONAL RESEARCH ON COGNITIVE, MOTOR, SLEEP AND CIRCADIAN RHYTHMS ALTERATIONS IN DIFFERENT PATHOLOGICAL SITUATIONS, INCLUDING: MINIMAL AND CLINICAL HEPATIC ENCEPHALOPATHY (HE), HYPERAMMONEMIA AND DEVELOPMENTAL EXPOSURE TO FOOD AND ENVIRONMENTAL CONTAMINANTS.
We also apply our wide range of methodologies to other pathological situations. The aims are:
In animal models:
- Unveil the molecular mechanisms leading to neurological impairment.
- Identify new therapeutic targets for its treatment.
- Design and assess new therapeutic procedures to reverse neurological impairment.
In patients:
- Study the mechanisms, diagnosis and treatment of neurological impairment.
- Identify early diagnostic procedures for neurological impairment.
- Bring to the clinic the diagnostic procedures identified.
PRESENTATION
GET TO KNOW US BETTER
RESEARCH STAFF
THE PEOPLE WHO MAKE IT ALL POSSIBLE
Carmina Montoliu Felix
cmontoliu@cipf.es
José Tomás Real
Amparo Urios Lluch
aurios@cipf.es
Andrea Cabrera Pastor
Danna Campos Hoyos
Laura ávila
María Oliver
Cristina Montón
Desamparados Escudero
Gergana Mincheva Ganeva
givaylova@cipf.es
Juan Tosca
José Ballester
María Pilar Ballester
Paloma Lluch
Paula Izquierdo Altarejos
pizquierdo@cipf.es
Sergio Martinez
Adriá López Gramaje
Concepción Gómez
PUBLICATIONS
OUR SCIENTIFIC CONTRIBUTIONS
Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-kappa B pathway
Journal of Neuroinflammation 2020 Feb, DOI: 10.1186/s12974-020-01746-z, Vol. 17, pag. 70-70
Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy
Journal of Clinical Medicine 2020 Jul, DOI: 10.3390/jcm9072154, Vol. 9, pag.
Hyperammonemia alters the mismatch negativity in the auditory evoked potential by altering functional connectivity and neurotransmission
JOURNAL OF NEUROCHEMISTRY 2020 Jul, DOI: 10.1111/jnc.14941, Vol. 154, pag. 56-70