Biomodels Facility

Core Facilities

The Biomodels Facility at CIPF has established itself as a benchmark in the development and application of advanced biomodels for biomedical research. Our primary goal is to foster synergies between basic research, clinical practice, and industry, driving knowledge transfer and the creation of innovative solutions.

Being part of the ISCIII Platform strengthens our capacity to expand our service portfolio and build strategic collaborations, thereby enhancing the impact of our activities across multiple areas of biomedicine.

At the Biomodels Facility, we are committed to updating and disseminating cutting-edge technological tools, ensuring their practical application in research and contributing to the advancement of science and health on a global scale.

Our mission is to bring the most advanced tools closer to the scientific and biomedical community, facilitating the translation of research into concrete progress that improves people’s health.

Our services are organized into four specialized areas:

  • Computational and Screening Tools
  • Organoids
  • Animal Models of Disease
  • 3D and Bioprinting Technologies.

SCREENING AND COMPUTATIONAL

SERVICES

COMPUTATIONAL STRATEGIES

    • Technology / Equipment: High-performance computing cluster
    • Research Group: Computational Biomedicine
    • Contact Person: Francisco García (fgarcia@cipf.es)
    • Research Group: Computational Biomedicine
    • Contact Person: Francisco García (fgarcia@cipf.es)
    • Research Group: Computational Biomedicine
    • Contact Person: Francisco García (fgarcia@cipf.es)
    • Research Group: Computational Biomedicine
    • Contact Person: Francisco García (fgarcia@cipf.es)
    • Research Group: Computational Biomedicine
    • Contact Person: Francisco García (fgarcia@cipf.es)
    • Research Group: Computational Biomedicine
    • Contact Person: Francisco García (fgarcia@cipf.es)

SCREENING

    • Technology / Equipment: MultiFlo FX Multimode Dispenser (96-well and 384-well magnetic wash capabilities)
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Technology / Equipment: EvoTECAN Li-Ha MCA96 (Screening in 96- or 384-well plate)
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Additional Techniques: Complementary Assays to Cytotoxicity (cell cycle, apoptosis and cell death, Mitochondrial Membrane Potential Assay)
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Technology / Equipment: ClarioStar Multimode Plate Reader with AlphaScreen technology and atmospheric control by BMG LABTECH, Ensight Multimode Plate Reader with Label-free technology by PerkinElmer
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Technology / Equipment: Myriad library: 10k compounds Prestwick library > 5k, Acces to European Chemical Biology Library (ECBL)
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Technology / Equipment: NanoSight-NTA NS300
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)
    • Additional Techniques: Statistical validation of experiments, Intellectual property research, Development of medicinal chemistry (‘hit to lead’ drug discovery), Validation of biological activity in animal models, Detection and Quantification of Protein Expression( Western Blotting, flow cytometry,Immunocytochemistry and RNA and DNA Techniques), Complete Histological Processing
    • Research Group: Cribado farmacológico
    • Contact Person: Esther Masiá / María Jesús Vicent (emasia@cipf.es / mjvicent@cipf.es)

ORGANOIDS

SERVICES

    • Organoid Type / Classification: Spheroids – Prostate
    • Tumor Type / Disease: Prostate cancer
    • Cell Source: VCaP, PC3, CAF
    • Offered Services: 3D culture, technical support, collaboration
    • Unit / Center: CIPF
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent / Ana Armiñán (mjvicent@cipf.es / aarminan@cipf.es)
    • Observations: Heterospheroids: VCaP+CAF, PC3+CAF; Homospheroids
    • Organoid Type / Classification: Spheroids – Mammary epithelium
    • Tumor Type / Disease: Breast cancer
    • Cell Source: MCF-7, MDA-MB-231, MDA-MB-453, ZR-75-1
    • Offered Services: 3D culture, technical support, collaboration
    • Additional Techniques: Grown in matrix
    • Unit / Center: CIPF
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent / Ana Armiñán (mjvicent@cipf.es / aarminan@cipf.es)
    • Organoid Type / Classification: Spheroids – Ovary
    • Tumor Type / Disease: Ovarian cancer
    • Organism Origin: Malignant effusion from peritoneal ascites
    • Cell Source: PEO6, ID-8
    • Offered Services: 3D culture, technical support, collaboration
    • Unit / Center: CIPF
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent / Ana Armiñán (mjvicent@cipf.es / aarminan@cipf.es)
    • Organoid Type / Classification: Patient-Derived Organoids – Mammary epithelium
    • Tumor Type / Disease: Breast cancer
    • Cell Source: Triple negative, HER2+, Hormonal dependent
    • Frozen Organoids Available: Yes
    • Offered Services: 3D culture, technical support, collaboration
    • Unit / Center: CIPF
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent / Ana Armiñán (mjvicent@cipf.es / aarminan@cipf.es)
    • Organoid Type / Classification: Spheroids – Lung
    • Tumor Type / Disease: Lung carcinoma
    • Organism Origin: Alveolar basal epithelial cells
    • Cell Source: A549, H1650, PC-9, H23, H1395, H1993
    • Offered Services: 3D culture, technical support, collaboration
    • Unit / Center: CIPF
    • Research Group: Oncogenic Signaling
    • Contact Person: Rosa Farrás (rfarras@cipf.es)
    • Organoid Type / Classification: Spheroids – Tibia
    • Tumor Type / Disease: Osteosarcoma
    • Cell Source: U20S
    • Offered Services: 3D culture, technical support, collaboration
    • Unit / Center: CIPF
    • Research Group: Oncogenic Signaling
    • Contact Person: Rosa Farrás (rfarras@cipf.es)
    • Organoid Type / Classification: Spheroids – Uterus
    • Tumor Type / Disease: Cervix cancer
    • Cell Source: HELA
    • Offered Services: 3D culture, technical support, collaboration
    • Unit / Center: CIPF
    • Research Group: Oncogenic Signaling
    • Contact Person: Rosa Farrás (rfarras@cipf.es)
    • Organoid Type / Classification: PDO – Lung
    • Tumor Type / Disease: Lung carcinoma
    • Cell Source: 33 patient-derived tumor samples
    • Frozen Organoids Available: Yes
    • Offered Services: 3D culture, technical support, collaboration
    • Unit / Center: CIPF
    • Research Group: Oncogenic Signaling
    • Contact Person: Rosa Farrás (rfarras@cipf.es)
    • Observations: Generation of short-term organoids
    • Additional Available Techniques: Imagining and cytomics service
    • Unit / Center: CIPF
    • Research Group: Oncogenic Signaling
    • Contact Person: Rosa Farrás (rfarras@cipf.es)
    • Unit / Center: CIPF
    • Research Group: Oncogenic Signaling
    • Contact Person: Rosa Farrás (rfarras@cipf.es)

3D PRINTING

SERVICES

    • Offered Services: Design and manufacturing of anatomical 3D models
    • Equipment: SLA (Formlabs 3B+)
    • Model: Anatomical models
    • Research Group: Bioengineering of Cellular Behavior
    • Contact Person: Anna Labernadie (alabernadie@cipf.es)
    • Offered Services: Technical consulting for 3D model development
    • Equipment: 3D model cutting machine
    • Model: Mold-guide elements for microscopy devices
    • Research Group: Bioengineering of Cellular Behavior
    • Contact Person: Anna Labernadie (alabernadie@cipf.es)
    • Offered Services: Training in technical procedures and image analysis
    • Equipment: Sealer
    • Model: Microfluidic platforms
    • References: PMID: 32939725, PMID: 28218910
    • Research Group: Bioengineering of Cellular Behavior
    • Contact Person: Anna Labernadie (alabernadie@cipf.es)
    • Offered Services: Manufacturing and repair of parts for technological equipment
    • Model: 3D culture systems
    • References: PMID: 32939725
    • Research Group: Bioengineering of Cellular Behavior
    • Contact Person: Anna Labernadie (alabernadie@cipf.es)
    • Offered Services: Development and fabrication of silicon and agarose-based components
    • Model: Silicon/agarose elements
    • Research Group: Bioengineering of Cellular Behavior
    • Contact Person: Anna Labernadie (alabernadie@cipf.es)

ANIMAL MODELS OF DISEASE

SERVICES

    • Technology / Equipment: Slit lamp and cobalt blue light
    • Animal Species: Mice, rat
    • Animal strain / model: Rd10, Db/db
    • Availability: Live
    • Thematic Area: In-vivo optical imaging in rodents
    • Specific pathology: Retinal degeneration deseases
    • Pathology: Retinal degeneration diseases
    • Alternative Pathology: Diabetic Retinopathy, Retinitis Pigmentosa
    • Model Description: In vivo technique to recognize corneal damages (slit-lamp)
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Vision Disease Pathophysiology and Therapies
    • Contact Person: Regina Rodrigo (rrodrigo@cipf.es)
    • Technology / Equipment: Reti-port/scan21 Faraday chamber
    • Animal Species: Mice, rat
    • Availability: Live
    • Thematic Area: In-vivo optical imaging in rodents
    • Specific pathology: Retinal degeneration deseases
    • Pathology: Retinal degeneration diseases
    • Alternative Pathology: Diabetic Retinopathy, Retinitis Pigmentosa
    • Model Description: In vivo response of the electrical function of retinal cells. Implemented with Faraday chamber
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 36670960
    • Research Group: Vision Disease Pathophysiology and Therapies
    • Contact Person: Regina Rodrigo (rrodrigo@cipf.es)
    • Technology / Equipment: Argos biometre
    • Animal Species: Mice, rat
    • Availability: Live
    • Thematic Area: In-vivo optical imaging in rodents
    • Specific pathology: Retinal degeneration deseases
    • Pathology: Retinal degeneration diseases
    • Alternative Pathology: Diabetic Retinopathy, Retinitis Pigmentosa
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Vision Disease Pathophysiology and Therapies
    • Contact Person: Regina Rodrigo (rrodrigo@cipf.es)
    • Technology / Equipment: Micron IV Ophthalmic imaging systems
    • Animal Species: Mice, rat
    • Availability: Live
    • Thematic Area: In-vivo optical imaging in rodents
    • Specific pathology: Retinal degeneration deseases
    • Pathology: Retinal degeneration diseases
    • Alternative Pathology: Diabetic Retinopathy, Retinitis Pigmentosa
    • Model Description: In vivo Fundoscopy studies, Retinal Vascularization and Angiography
    • Model Description: In vivo response of the electrical function of retinal cells. Implemented with Faraday chamber
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Vision Disease Pathophysiology and Therapies
    • Contact Person: Regina Rodrigo (rrodrigo@cipf.es)
    • Animal Species: Pig (eyes)
    • Availability: Ex vivo
    • Thematic Area: In-vivo optical imaging in rodents
    • Specific pathology: Retinal degeneration deseases
    • Pathology: Diabetic Retinopathy Retinosis Pigmentaria Ischemic Retinopathy
    • Alternative Pathology: Diabetic Retinopathy, Retinitis Pigmentosa
    • Model Description: Explants were cultured at 37°C under normoxia or mild hypoxia conditions for 24h
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 37440070
    • Research Group: Vision Disease Pathophysiology and Therapies
    • Contact Person: Regina Rodrigo (rrodrigo@cipf.es)
    • Technology / Equipment: Light Dark Box with Anymaze software
    • Animal Species: Mice, rat
    • Availability: Ex vivo
    • Thematic Area: Animal behavior
    • Specific pathology: Retinal degeneration deseases
    • Pathology: Diabetic Retinopathy Retinosis Pigmentaria Ischemic Retinopathy
    • Alternative Pathology: Diabetic Retinopathy, Retinitis Pigmentosa
    • Model Description: Innate aversion of rodents to brightly illuminated areas and on the spontaneous exploratory behaviour of rodents in response to mild stressors
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Vision Disease Pathophysiology and Therapies
    • Contact Person: Regina Rodrigo (rrodrigo@cipf.es)
    • Animal Species: Mice, rat
    • Availability: Live
    • Specific pathology: Retinal degeneration deseases
    • Pathology: Diabetic Retinopathy Retinosis Pigmentaria Ischemic Retinopathy
    • Alternative Pathology: Diabetic Retinopathy, Retinitis Pigmentosa
    • Model Description: Mice were anesthetized and their pupils were dilated. Intravitreal injections are performed using a surgical microscope
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: DOI: 10.1096/fj.202000044RR
    • Research Group: Vision Disease Pathophysiology and Therapies
    • Contact Person: Regina Rodrigo (rrodrigo@cipf.es)
    • Technology / Equipment: Cell sorting
    • Animal Species: Mice, rat
    • Specific pathology: Retinal degeneration deseases
    • Alternative Pathology: Diabetic Retinopathy, Retinitis Pigmentosa
    • Model Description: Isolated retinal microglia by flow cytometry
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 36670960
    • Research Group: Vision Disease Pathophysiology and Therapies
    • Contact Person: Regina Rodrigo (rrodrigo@cipf.es)
    • Animal Species: Mice
    • Animal strain / model: Balb/C
    • Availability: Live
    • Thematic Area: Breast Cancer
    • Model Description: Localized injection into the mammary gland of 4T1 triple-negative cells
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Therapeutics Polymers / Targeted Therapies in Cancer and Inflammation
    • Contact Person: María Jesús Vicent (mjvicent@cipf.es)
    • Technology / Equipment: IVIS
    • Animal Species: Mice
    • Animal strain / model: Nod/Scid
    • Availability: Ex-vivo
    • Thematic Area: Breast Cancer
    • Pathology: Lung metastasis
    • Model Description: Localized injection into the mammary gland of MDA_MB231 triple-negative or E0771 cells . Luciferine trasnfected
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent (mjvicent@cipf.es)
    • Technology / Equipment: IVIS
    • Animal Species: Mice
    • Animal strain / model: Scid
    • Availability: Live
    • Thematic Area: Prostate Cancer
    • Model Description: Localized injection into the prostate of VCAP cells. Luciferine trasnfected
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent (mjvicent@cipf.es)
    • Technology / Equipment: IVIS, Computed tomography (CT)
    • Animal Species: Mice
    • Animal strain / model: Nod/Scid
    • Availability: Live, ex-vivo
    • Thematic Area: Prostate Cancer
    • Pathology: Bone metastasis
    • Model Description: Intratibial injection of PC3 cells. Luciferine trasnfected. In vivo monitoring of cathepsin K levels and ex vivo CT for bone damage quantification
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent (mjvicent@cipf.es)
    • Technology / Equipment: IVIS
    • Animal Species: Mice
    • Animal strain / model: C57/BL6
    • Availability: Live
    • Thematic Area: Abdominal cancer
    • Model Description: Intraperitoneal injection of 1D8 cells.Luciferine trasnfected
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent (mjvicent@cipf.es)
    • Technology / Equipment: Intravital microscopy
    • Animal Species: Mice
    • Availability: Live
    • Thematic Area: In-vivo imaging in rodents
    • Model Description: Determination of the half-life of compounds labeled with fluorescence
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent (mjvicent@cipf.es)
    • Technology / Equipment: IVIS
    • Animal Species: Mice
    • Availability: Live
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent (mjvicent@cipf.es)
    • Technology / Equipment: IVIS
    • Animal Species: Mice
    • Availability: Live
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent (mjvicent@cipf.es)
    • Animal Species: Mice
    • Availability: Ex-vivo
    • Model Description: Histological analysis, immunological activation, hematopoiesis modulation, marker search
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent (mjvicent@cipf.es)
    • Animal Species: Mice
    • Availability: Ex-vivo
    • Model Description: Repeated extraction at different times of venous blood in mice
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Therapeutics Polymers
    • Contact Person: María Jesús Vicent (mjvicent@cipf.es)
    • Technology / Equipment: Glucose meter
    • Animal Species: Mice
    • Animal strain / model: C57/BL6
    • Availability: Live
    • Model Description: Typically glucose tolerance tests (GTTs) are performed at 12 weeks of age, followed by an Insulin tolerrance test (ITT) 2 weeks later. Some mice are put on High Fat Diet and an ITT repeated following 10 weeks
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Obesity, diabetes, and comorbidities
    • Contact Person: Stefania Carobbio (scarobbio@cipf.es)
    • Technology / Equipment: Pheno Master
    • Animal Species: Mice
    • Availability: Live
    • Thematic Area: Metabolic deseases
    • Model Description: Three disciplines combined within a single fully automated home cage phenotyping system. Metabolic, behavioural and physiological
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Obesity, diabetes, and comorbidities
    • Contact Person: Stefania Carobbio (scarobbio@cipf.es)
    • Technology / Equipment: IVIS
    • Animal Species: Mice
    • Animal strain / model: C57/BL6
    • Availability: Live
    • Thematic Area: Metabolic deseases
    • Model Description: Trasplant of human adipose tissue-derived stem cells.Experimental model in the process of optimization
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 36670960
    • Research Group: Obesity, diabetes, and comorbidities
    • Contact Person: Stefania Carobbio (scarobbio@cipf.es)
    • Animal Species: Mice
    • Animal strain / model: Nod/Scid
    • Availability: Live
    • Thematic Area: Lung adenocarcinoma
    • Model Description: A 1 mm³ tumor sample is implanted in immunodeficient mice
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 34638519
    • Research Group: Oncogenic signaling
    • Contact Person: Rosa Farrás (rfarras@cipf.es)
    • Animal Species: Mice
    • Animal strain / model: Nod/Scid
    • Availability: Live
    • Thematic Area: Osteosarcoma
    • Model Description: Subcutaneous injection of the U20S cell line in immunodeficient mice
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 34638519
    • Research Group: Oncogenic signaling
    • Contact Person: Rosa Farrás (rfarras@cipf.es)
    • Animal Species: Mice
    • Availability: Live
    • Thematic Area: Peritonitis
    • Model Description: Intraperitoneal injection of urea crystals. Peritoneal lavage at 6h for cell collection and specific cytokine counting.
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Targeted Therapies in Cancer and Inflammation
    • Contact Person: Mar Orzaez (morzaez@cipf.es)
    • Animal Species: Mice
    • Animal strain / model: Balb/C
    • Availability: Live
    • Thematic Area: Cancer and inflamation
    • Model Description: Galactosidase activity is measured after the local injection of the 4T1 triple-negative cells
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Targeted Therapies in Cancer and Inflammation
    • Contact Person: Mar Orzaez (morzaez@cipf.es)
    • Animal Species: Mice
    • Animal strain / model: CD1
    • Availability: Live
    • Thematic Area: Cancer and inflamation
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 37515468
    • Research Group: Targeted Therapies in Cancer and Inflammation
    • Contact Person: Mar Orzaez (morzaez@cipf.es)
    • Technology / Equipment: Stereotxy
    • Animal Species: Mice
    • Animal strain / model: C57/BL6
    • Availability: Live
    • Thematic Area: Traumatic injury and cortical damage
    • Pathology: Hemorragic stroke
    • Model Description: Mice were placed in a stereotaxic frame, under isofluorane anesthesia with the skull exposed. To target the primary motor cortex, specific coordinates (mm) were selected.To perform the controlled cortical damage (CCD), a 2.1 mm diameter drill tip was introduced in the right primary motor cortex at a constant speed of 0.5 mm/s, using a motorized stereotaxic instrument to reduce injury variation
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 35897786
    • Research Group: Cortical Circuits in Health and Disease
    • Contact Person: Pietro Fazzari (pfazzari@cipf.es)
    • Animal Species: Mice
    • Availability: Live
    • Thematic Area: Motor Behavior Analysis
    • Model Description: Mice walked through a wooden pole elevated 1 m height from the table.The pole can display 3 different modes: 1 static mode, in which it remains stopped, and 2 rotation modes to the right or left direction at 3 rpm speed
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 35897787
    • Research Group: Cortical Circuits in Health and Disease
    • Contact Person: Pietro Fazzari (pfazzari@cipf.es)
    • Technology / Equipment: The Catwalk XT system
    • Animal Species: Mice
    • Availability: Live
    • Thematic Area: Motor Behavior Analysis
    • Model Description: The Catwalk XT system consists of an enclosed walkway on a glass surface, illuminated with specific light combination
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 35897788
    • Research Group: Cortical Circuits in Health and Disease
    • Contact Person: Pietro Fazzari (pfazzari@cipf.es)
    • Technology / Equipment: MotoRater TE system
    • Animal Species: Mice
    • Availability: Live
    • Thematic Area: Motor Behavior Analysis
    • Model Description: mice walked 3 times over two ladders, which differed in bar spaced distance (1 or 3 cm, respectively)
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 35897789
    • Research Group: Cortical Circuits in Health and Disease
    • Contact Person: Pietro Fazzari (pfazzari@cipf.es)
    • Technology / Equipment: Treadmill
    • Animal Species: Mice
    • Availability: Live
    • Thematic Area: Motor Behavior Analysis
    • Model Description: mice are motivated to run to avoid touching the electrified grid located at the back of the lane
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 35897790
    • Research Group: Cortical Circuits in Health and Disease
    • Contact Person: Pietro Fazzari (pfazzari@cipf.es)
    • Animal Species: Mice
    • Availability: Ex-vivo
    • Model Description: Mice were transcardially perfused with 4% paraformaldehyde to collect the brain. The brains were sectioned with a cryostat at 40 µm
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 35897791
    • Research Group: Cortical Circuits in Health and Disease
    • Contact Person: Pietro Fazzari (pfazzari@cipf.es)
    • Animal Species: Mice
    • Availability: Live
    • Thematic Area: Schizofrenia
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Research Group: Cortical Circuits in Health and Disease
    • Contact Person: Pietro Fazzari (pfazzari@cipf.es)
    • Animal Species: Mice
    • Availability: Live
    • Thematic Area: Schizofrenia
    • Model Description: phenotiping in course
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Cortical Circuits in Health and Disease
    • Contact Person: Pietro Fazzari (pfazzari@cipf.es)
    • Technology / Equipment: Stereotxy
    • Animal Species: Mice
    • Animal strain / model: Pten ko mice
    • Availability: Live
    • Thematic Area: Spinal cord injury (SCI)
    • Pathology: Regenerative medicine
    • Alternative Pathology: Spinal cord injury (SCI)
    • Model Description: Complete injury was performed by the T7–T10 double laminectomy. An incision was made using a micro scalpel blade on the right T7 side and the left side at T10 level until midline. These incisions were performed twice to ensure complete severing
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 35897791
    • Research Group: Neuronal and tisular regeneration
    • Contact Person: Victoria Moreno (vmorenom@cipf.es)
    • Technology / Equipment: CatWalk Xl,Motorater
    • Animal Species: Mice, rat
    • Animal strain / model: Sprague-Dawley Rats and C57/BL6 mice
    • Availability: Live
    • Thematic Area: Spinal cord injury (SCI)
    • Pathology: Regenerative medicine
    • Alternative Pathology: Spinal cord injury (SCI)
    • Model Description: Behavioral analysis of locomotion by using open field test and BBB score; gait analysis by using CatWalk XL, kinematics using Motorater, coordinated wallking by using narrow beam and crossobeam test, inclinated plane
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 38556794
    • Research Group: Neuronal and tisular regeneration
    • Contact Person: Victoria Moreno (vmorenom@cipf.es)
    • Animal Species: Mice, rat
    • Animal strain / model: Sprague-Dawley Rats and C57/BL6 mice
    • Availability: Live
    • Thematic Area: Sensorial Analysis
    • Pathology: Regenerative medicine
    • Alternative Pathology: Spinal cord injury (SCI)
    • Model Description: Von Frey filaments in ascending order were applied an equal number of times (three) for each paw until a withdrawal was recorded and assigned as the “mechanical withdrawal threshold” (g). The mean of each paw was then plotted
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 38556795
    • Research Group: Neuronal and tisular regeneration
    • Contact Person: Victoria Moreno (vmorenom@cipf.es)
    • Technology / Equipment: Aperio Versa scanner, Zeiss Apotome, Leica Aperio Scope
    • Animal Species: Mice, rat
    • Animal strain / model: Sprague-Dawley Rats and C57/BL6 mice
    • Availability: Ex-vivo
    • Thematic Area: Motor Behavior Analysis
    • Pathology: Regenerative medicine
    • Alternative Pathology: Spinal cord injury (SCI)
    • Model Description: Inflammatory microglia profile analysis.Neuronal fiber analysis.Myelin preservation analysis.Fibronectin expression analysis.Excitability and inhibitory neuronal input analysis
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 38556796
    • Research Group: Neuronal and tisular regeneration
    • Contact Person: Victoria Moreno (vmorenom@cipf.es)
    • Animal Species: Mice, rat
    • Animal strain / model: Sprague-Dawley Rats and C57/BL6 mice
    • Availability: Live
    • Thematic Area: Cell transplantation/scaffolds-hydrogels
    • Pathology: Regenerative medicine
    • Alternative Pathology: Spinal cord injury (SCI)
    • Model Description: Cell transplantation and or implants of different materials in the treatment area, such as hydrogels, adenoviruses and scaffolds
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • References: PMID: 30726582
    • Research Group: Neuronal and tisular regeneration
    • Contact Person: Victoria Moreno (vmorenom@cipf.es)
    • Technology / Equipment: IVIS
    • Animal Species: Mice
    • Animal strain / model: C57/BL6
    • Availability: Live
    • Thematic Area: Ovarian cancer, Pancreatic cancer
    • Model Description: IP injection of ID8 and HGS2 for ovarian cancer and KPC-HAPLNI for pancreatic cancer. The tumor growth will be monitored by luminescence using the IVIS imaging system
    • Service Type: Experimental, technical support
    • Collaboration: Yes
    • Training: Yes
    • Research Group: Tumor-Stroma Communication
    • Contact Person: Juan R.Vita (jrodriguez@cipf.es)

CONTACT US

For inquiries, please contact:
Patricia Conde
Manager
pconde@cipf.es

María Jesús Vicent
Scientific Coordinator
mjvicent@cipf.es