Tumor-Stroma Communication

Juan Rodríguez Vita

THE TUMOR-STROMA COMMUNICATION GROUP AIMS TO DECIPHER THE COMPLICATED CONNECTIONS BETWEEN CANCER CELLS AND THE STROMA CONTAINED IN TUMORS.

This stroma may be composed of cells or extracellular matrix proteins. Most of our work has focused on this particularity, we have described how tumor cells alter the membrane composition of macrophages, inducing dysregulation in signaling pathways that transduce inflammatory signaling and ultimately lead to immunosuppression. We have also contributed to demonstrate how tumor cells induce endothelial cell senescence, making the endothelium more permeable and enhancing metastasis. Ultimately, our research focuses on how tumor cells and stroma interact with each other, and how this interaction may influence tumor development. On the other hand, the group focuses on one of the main causes for mortality in cancer patients, cachexia. Cachexia is characterized by remodeling of white adipose tissue, which leads to altered lipid storage, apoptosis, inflammation and, ultimately, fibrosis of this tissue. Tissue wasting occurs in response to factors secreted by the cancer. Our group is studying the role of adipose tissue inflammation in the development of cachexia.

PRESENTATION

GET TO KNOW US BETTER

  • Own scientific image of the laboratory
  • Own scientific image of the laboratory

RESEARCH STAFF

THE PEOPLE WHO MAKE IT ALL POSSIBLE

Juan Rodriguez Vita
jrodriguez@cipf.es

Maravillas Mellado López
mmellado@cipf.es

Xiyi Chen 
xchen@cipf.es

Francesca De Angelis Rigotti
fangelis@cipf.es

Francesca Pontis 
fpontis@cipf.es

Amelia Ultimo 
aultimo@cipf.es

Irene Zúñiga Centenero
izuniga@cipf.es

PUBLICATIONS

OUR SCIENTIFIC CONTRIBUTIONS

Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia.

Taylor J, Uhl L, Moll I, Hasan SS, Wiedmann L, Morgenstern J, Giaimo BD, Friedrich T, Alsina-Sanchis E, De Angelis Rigotti F, Mülfarth R, Kaltenbach S, Schenk D, Nickel F, Fleming T, Sprinzak D, Mogler C, Korff T, Billeter AT, Müller-Stich BP, Berriel Diaz M, Borggrefe T, Herzig S, Rohm M, Rodriguez-Vita J and Fischer A

Nature Cancer 2023 Nov,  DOI:  10.1038/s43018-023-00622-y,  Vol. 4,  pag. 1544-1560

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HAPLN1 potentiates peritoneal metastasis in pancreatic cancer.

Wiedmann L, De Angelis Rigotti F, Vaquero-Siguero N, Donato E, Espinet E, Moll I, Alsina-Sanchis E, Bohnenberger H, Fernandez-Florido E, Mülfarth R, Vacca M, Gerwing J, Conradi LC, Ströbel P, Trumpp A, Mogler C, Fischer A and Rodriguez-Vita J

Nature Communications 2023 Apr,  DOI:  10.1038/s41467-023-38064-w,  Vol. 14,  pag. 2353-2353

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Semaphorin 3C exacerbates liver fibrosis.

De Angelis Rigotti F, Wiedmann L, Hubert MO, Vacca M, Hasan SS, Moll I, Carvajal S, Jiménez W, Starostecka M, Billeter AT, Müller-Stich B, Wolff G, Ekim-Üstünel B, Herzig S, Fandos-Ramo C, Krätzner R, Reich M, Keitel-Anselmino V, Heikenwälder M, Mogler C, Fischer A and Rodriguez-Vita J

HEPATOLOGY 2023 Oct,  DOI:  10.1097/HEP.0000000000000407,  Vol. 78,  pag. 1092-1105

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Endothelial RBPJ is essential for the education of tumor-associated macrophages.

Alsina-Sanchis E, Mülfarth R, Moll I, Böhn S, Wiedmann L, Jordana-Urriza L, Ziegelbauer T, Zimmer E, Taylor J, De Angelis Rigotti F, Stögbauer A, Giaimo BD, Cerwenka A, Borggrefe T, Fischer A and Rodriguez-Vita J

CANCER RESEARCH 2022 Dec,  DOI:  10.1158/0008-5472.CAN-22-0076,  Vol. 82,  pag. 4414-4428

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Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression.

Goossens P, Rodriguez-Vita J, Etzerodt A, Masse M, Rastoin O, Gouirand V, Ulas T, Papantonopoulou O, Van Eck M, Auphan-Anezin N, Bebien M, Verthuy C, Vu Manh TP, Turner M, Dalod M, Schultze JL and Lawrence T

Cell Metabolism 2019 Jun,  DOI:  10.1016/j.cmet.2019.02.016,  Vol. 29,  pag. 1376

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FUNDING

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