UPCOMING EVENTS
SHARING IDEAS AND RESEARCH FINDINGS



UPCOMING EVENTS
SHARING IDEAS AND RESEARCH FINDINGS
OUR UPCOMING
EVENTS
We are working towards becoming a reference center for knowledge, education, and scientific training in Valencia. One way we are achieving this is by regularly holding public events and strengthening our connections with local educational and civic entities. Hence, we offer an ample calendar of specific events designed both for the general public and for the wider scientific community.
this
month
May 2025
Event Details
Title: Development and application of novel computational approaches for the characterization of cancer subtypes Autor: Camilla Pegoraro Directors: María de la Iglesia-Vayá, Francisco García García Abstract: Cancer remains a global health
Event Details
Title: Development and application of novel computational approaches for the
characterization of cancer subtypes
Autor: Camilla Pegoraro
Directors: María de la Iglesia-Vayá, Francisco García García
Abstract: Cancer remains a global health crisis, demanding further research to understand its molecular basis. Even within the same cancer type, inter-patient variability is an obstacle to disease understanding and therapy development. Cancer subtyping, therefore, becomes essential to address cancer heterogeneity. One promising approach to unravel this heterogeneity is through cancer subtyping based on the transcriptomic landscape of patients. Through gene expression profiling, researchers can identify groups of patients that may represent distinct cancer subtypes with unique biological characteristics, response to therapies and clinical outcomes. However, this approach has its major challenge in requiring large sample sizes, which are crucial for the identification of meaningful subtypes.
This is where transcriptomics data meta-analysis emerges as a powerful statistical tool. By systematically collecting and re-analyzing data from public repositories,
researchers can integrate sample sizes across multiple studies, overcoming the limitations of individual datasets. This approach allows for the identification of subtle
yet critical differences in gene expression patterns that might be missed in smaller cohorts. In this thesis, we explored cancer heterogeneity in two distinct contexts: lung adenocarcinoma and pancreatic ductal adenocarcinoma. We used an in-silico approach, leveraging published data through meta-analysis, overcoming limitations
of individual studies, and driving novel discoveries. We have identified sex-specific transcriptomic differences in lung adenocarcinoma, particularly in the immune system, purinergic signaling, and lipid metabolism pathways. We have also characterized the transcriptomic landscape of pancreatic ductal adenocarcinoma and its links to patient survival, revealing two prognostic gene signatures associated with the immune system and the extracellular matrix.
Time
07.05.2025 12:30 - 14:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
08may12:0013:00SEMINAR: Juan José Esteve / Carla Perpiñá
Event Details
12:00 – 12:30 – Juan José Esteve Smart Nanoparticles for Targeted Cancer Therapy: From Controlled Drug Release to Self-Propelled Nanomotors Abstract: Nanomedicine has revolutionized cancer therapy by enabling precise drug
Event Details
12:00 – 12:30 – Juan José Esteve
Smart Nanoparticles for Targeted Cancer Therapy: From Controlled Drug Release to Self-Propelled Nanomotors
Abstract: Nanomedicine has revolutionized cancer therapy by enabling precise drug delivery, minimizing side effects, and improving treatment efficacy. Advanced nanocarriers offer innovative strategies to overcome biological barriers and enhance therapeutic outcomes. Here we present a collection of “smart” and multifunctional nanoparticles to release cytotoxic drugs in a controlled manner (using molecular gates or magnetic field), improving the therapeutic effect of the drugs.
In recent years, near-infrared (NIR) light has gained significant interest as a strategy for localized tumor treatment due to its precise targeting capabilities. We have developed two systems based on gold nanostars to enable photoactivation of Doxorubicin prodrugs by NIR light. The results demosntrated that the chemotherapeutic agent is released exclusively at the irradiated site and significantly improved therapeutic effect in a melanoma tumor model.
On the other hand, we developed nanoparticles with autonomous movement (nanomotors) to enhanced drug delivery into deep areas of the tumors. In this case, Janus nanoparticles based on platinum and mesoporous silica nanoparticles (MSNs) faces were used as scaffold. Doxorubicin was loaded into the pores of MSNs and the enzyme lactate oxidase (Lox) was used as capping ensemble (to control drug release) and unit to start the movement. The movement is driven by catalytic elements (e.g., metals or enzymes) that convert surrounding chemical species into kinetic energy, enabling self-propulsion. The results demonstrated the remarkable advantages of the movement, including enhanced penetration in melanoma spheroids and improved therapeutic effect in a melanoma tumor model.
12:30 – 13:00 – Carla Perpiñà
Sex-Based Molecular Responses to Alcohol: Insights from Integrated Lipidomic and Transcriptomic Profiling from the Plasma Secretome
Abstract: Sex influences the biological response to alcohol at multiple molecular levels. In this talk, I will present findings from my PhD project, which integrates lipidomic and miRNA analyses of plasma extracellular vesicles to study the effects of binge drinking and alcohol use disorder (AUD) in both humans and mouse models (WT and TLR4-KO), with a particular focus on sex differences. Our principal findings in humans with AUD reveal sex-specific molecular signatures associated with neuroinflammation, hepatotoxicity, and cancer-related pathways. In females, we observed alterations in lysophosphatidylcholine/phosphatidylcholine ratios and increased phospholipase activity, suggesting enhanced neuroinflammatory and oncogenic signaling. In contrast, males exhibited disruptions in sphingomyelin metabolism, pointing to hepatotoxic effects. Functional miRNA analyses further highlight sex-divergent regulation of gene expression, protein turnover, vesicle trafficking, and neuronal structure. Additionally, integrative multi-omic analysis revealed that both alcohol exposure and sex significantly contribute to the observed molecular variance. This multi-omic approach uncovers novel sex-dependent biomarkers and mechanisms, offering new insights into the molecular basis of alcohol-related disorders.
Time
08.05.2025 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
09may10:3012:00Avances Preclínicos en Gotas Oculares para el Tratamiento de la Retinosis Pigmentaria
Event Details
Avances Preclínicos en Gotas Oculares para el Tratamiento de la Retinosis Pigmentaria ¿No puedes asistir? ACCESO ONLINE
Event Details
Avances Preclínicos en Gotas Oculares para el Tratamiento de la Retinosis Pigmentaria
¿No puedes asistir? ACCESO ONLINE
Time
09.05.2025 10:30 - 12:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Title: Study of molecular bases behind sex differences in non-alcoholic fatty liver disease and multiple sclerosis through transcriptomic meta-analysis Autor: Francisco Català Senent Directors: Francisco García García & Marta R. Hidalgo
Event Details
Title: Study of molecular bases behind sex differences in non-alcoholic fatty liver disease and multiple sclerosis through transcriptomic meta-analysis
Autor: Francisco Català Senent
Directors: Francisco García García & Marta R. Hidalgo
Abstract: Sex differences in health are one of the primary biases in medicine today. Traditionally, males have been used as models in research and medicine, ignoring the fact that the development, symptoms, and response to a pathology are not necessarily the same in both sexes. Fortunately, in recent decades, researchers and institutions have made significant advances to reduce this bias, with the aim of providing more efficient treatment of diseases.
In this context, this doctoral thesis has contributed in reducing sex bias in medicine by studying the molecular basis of sex-related alterations in two diseases with a significant impact on the population: non-alcoholic fatty liver disease (NAFLD) and multiple sclerosis (MS). NAFLD comprises a range of liver disorders that begin with an accumulation of fat in the hepatocytes (NAFL) and progress to the development of inflammation (NASH), which can lead to loss of liver function and cancer. The latest studies estimate the overall prevalence of the disease at around 30% (with an upward trend), being higher in men (40%) than in women (26%). Among women, a lower prevalence is observed in premenopausal women, while after menopause, it is equal to that of men. This high prevalence of the pathology makes NAFLD a worldwide problem and the most common liver disease in developed countries.
On the other hand, MS is a chronic autoimmune, inflammatory, and degenerative disease of the central nervous system. This pathology presents different forms and stages and can, in the most severe cases, seriously affect the quality of life of those who suffer from it. As is usual in neurodegenerative diseases, MS is more prevalent in women than in men and is mainly diagnosed in young adults.
In the NAFLD work, 7 studies, including 323 patients, were selected from the 114 baseline work. Meta-analyses identified molecular mechanisms significantly overexpressed in premenopausal women versus men, including processes associated with DNA regulation, vinculin binding, responses to interleukin-2 (IL-2), negative regulation of neuronal death, and ion and cation transport. In males, we discovered an overrepresentation of genes associated with negative regulation of interleukin-6 (IL-6) and the establishment of planar polarity involved in neural tube closure. The differences in immune response observed between premenopausal men and women in the transition from NAFL to NASH suggest the role of IL-2 and IL-6 in the differential progression of NAFLD as a function of sex.
On the other hand, in the chapter on MS, 122 publications were reviewed, of which 9 met the defined criteria. These 9 studies (5 of blood samples and 4 of brain tissue samples) included 474 individuals. The blood and brain tissue meta-analyses identified, respectively, 1 and 13 MS-associated genes altered differently between men and women. In the case of functional analyses in the brain, sex-associated immune patterns were detected, among others. Women were more affected in the proinflammatory environment and innate immune responses related to the myeloid lineage, whereas adaptive responses were more affected in men.
Overall, the results of this dissertation reaffirm the usefulness of the systematic review and meta-analysis strategy as a tool for the reuse of openly published data. In this case, the application of this methodology has allowed us to detect a set of molecular alterations affected differently between women and men in both non-alcoholic fatty liver disease and multiple sclerosis. Particularly noteworthy is the presence of changes associated with interleukins 2 and 6 in both diseases, which highlights the role that the immune system plays in sex-associated alterations. The results of this work open the door to further research to translate these results into clinical practice.
Time
12.05.2025 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
16may12:3013:30SEMINAR: Konstantin Mineev
Event Details
12:30 – Konstantin Mineev Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe University, Frankfurt/Main, Germ
Event Details
12:30 – Konstantin Mineev
Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe University, Frankfurt/Main, Germ
Time
16.05.2025 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Speaker: José Manuel García Aznar Aragon Institute of Engineering Research (I3A) Department of Mechanical Engineering University of Zaragoza Role of the mechanical microenvironment in tumor growth and immunotherapy: from microfluidic-based cultures
Event Details
Speaker: José Manuel García Aznar
Aragon Institute of Engineering Research (I3A)
Department of Mechanical Engineering
University of Zaragoza
Role of the mechanical microenvironment in tumor growth and immunotherapy: from microfluidic-based cultures to computational simulations
Abstract: Mechanobiology is a field of science that aims to understand how mechanics regulate biology. It focuses on how mechanical forces and alterations in mechanical properties of cell or tissues regulate biological processes in development, physiology and disease. In fact, all these processes occur in our body, which presents a clear structural and hierarchical organization that goes from the organism to the cellular level. To advance in the understanding of all these processes at different scales requires the use of simplified representations of our body, which is normally known as modelling or equivalently the creation of a model. Different types of models can be found in the literature: in-vitro, in-vivo and in-silico models.
Here, I will present our modelling strategy in which we integrate different mathematical models and in-vitro experiments in order to tackle relevant mechanical-based mechanisms in tumor growth and immunotherapy [1,2].
Due to the complexity of all these mechanisms, mathematical modelling is a relevant tool for providing deeper insight and quantitative predictions of the mechanical interplay between cells and extracellular matrix during cell migration and tumour growth. To assess the predictive capacity of these models, we will compare our numerical results with microfluidic-based experiments [2,3], which provide experimental information to test and refine the main assumptions of our models. Actually, we design and fabricate multi-channel 3D microfluidics cell culture chips, which allow recreating the tumour micro-environment by means of developing tumour organoids [4]. Therefore, this kind of organ-on-a-chip experiments constitutes a novel modelling strategy of in vitro multicellular human systems that in combination with mathematical simulations provide a relevant tool for research in mechanobiology.
In the presentation I will focus on showing our more recent findings about how matrix mechanics is regulating the size and organization of tumour organoids [5].
References
- Hervas-Raluy, S., Wirthl, B., Guerrero, P. E., Rei, G. R., Nitzler, J., Coronado, E., … & Wall, W. A. (2023). Tumour growth: An approach to calibrate parameters of a multiphase porous media model based on in vitro observations of Neuroblastoma spheroid growth in a hydrogel microenvironment. Computers in Biology and Medicine, 159, 106895.
- Gonçalves, I. G., & Garcia-Aznar, J. M. (2021). Extracellular matrix density regulates the formation of tumour spheroids through cell migration. PLoS computational biology, 17(2), e1008764.
- Plou, J., Juste-Lanas, Y., Olivares, V., Del Amo, C., Borau, C., & García-Aznar, J. M. (2018). From individual to collective 3D cancer dissemination: roles of collagen concentration and TGF-β. Scientific reports, 8(1), 12723.
- Hernández-Hatibi, S., Borau, C., Martínez-Bosch, N., Navarro, P., García-Aznar, J. M., & Guerrero, P. E. (2025). Quantitative characterization of the 3D self-organization of PDAC tumor spheroids reveals cell type and matrix dependence through advanced microscopy analysis. APL bioengineering, 9(1).
- Camacho-Gomez, D., Sorzabal-Bellido, I., Ortiz-de-Solorzano, C., Garcia-Aznar, J. M., & Gomez-Benito, M. J. (2023). A hybrid physics-based and data-driven framework for cellular biological systems: Application to the morphogenesis of organoids. Iscience, 26(7).
Time
20.05.2025 11:00 - 12:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
20may12:3013:30SEMINAR: Dr. Mark AlkemaThe extended phenotype: Diet, Microbiome and Behavior
Event Details
Speaker: Dr. Mark Alkema University of Massachusetts The extended phenotype: Diet, Microbiome and Behavior Abstract:
Event Details
Speaker: Dr. Mark Alkema
University of Massachusetts
The extended phenotype: Diet, Microbiome and Behavior
Abstract:
Time
20.05.2025 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
23may09:3014:00Jornada de Presentación de la Quimioteca Pública Española
Event Details
Jornada de Presentación de la Quimioteca Pública Española ¿No puedes asistir? ACCESO ONLINE
Event Details
Time
23.05.2025 09:30 - 14:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
29may12:0014:00THESIS: Andrea Millán Trejo
Event Details
Title: Gene regulatory mechanisms underlying the emergence of novel neuronal functions Autor: Andrea Millán Trejo Unidad de Neurobiología del Desarrollo. IBV, CSIC
Event Details
Title: Gene regulatory mechanisms underlying the emergence of novel neuronal functions
Autor: Andrea Millán Trejo
Unidad de Neurobiología del Desarrollo. IBV, CSIC
Time
29.05.2025 12:00 - 14:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Speaker: Álvaro Rada Iglesias «Synthetic engineering of enhancer landscapes provides novel insights into long-range gene regulation». Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC). Universidad de Cantabria/CSIC
Event Details
Speaker: Álvaro Rada Iglesias
«Synthetic engineering of enhancer landscapes provides novel insights into long-range gene regulation».
Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC). Universidad de Cantabria/CSIC
Time
30.05.2025 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
next
month
June 2025
Event Details
V Jornadas sobre Gestión de la Oncología de Precisión de la Comunidad Valenciana Estrategia del cáncer en la Comunidad Valencia en 2025
Event Details
V Jornadas sobre Gestión de la Oncología de Precisión de la Comunidad Valenciana Estrategia del cáncer en la Comunidad Valencia en 2025
Time
11.06.2025 15:00 - 17:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
12jun12:0013:00SEMINAR: Vicente Felipo / Amina Benaicha
Event Details
12:00 – 12:30 – Vicente Felipo Mechanisms leading to cognitive and motor impairment in hyperammonemia and hepatic encephalopathy. Therapeutic implications. Abstract: The main objectives of our group are to
Event Details
12:00 – 12:30 – Vicente Felipo
Mechanisms leading to cognitive and motor impairment in hyperammonemia and hepatic encephalopathy. Therapeutic implications.
Abstract: The main objectives of our group are to identify the mechanisms by which liver diseases lead to cognitive and motor impairment in patients with minimal hepatic encephalopathy (MHE) and design and assess in rat models new treatments for MHE.
We have been working on these objectives for many years. In this seminar, I will summarize some of our key studies in the last years both in cirrhotic patients with MHE and in rat models of hyperammonemia and MHE.
Some questions that we are studying are:
Which peripheral alterations are responsible for induction of MHE in cirrhotic patients?
How these peripheral alterations are transmitted to the brain?
How this induces neuroinflammation?
How neuroinflammation impairs neurotransmission?
How impaired neurotransmission leads to cognitive and motor impairment?
We have shown that: a) MHE appearance in patients is due to a pro-inflammatory shift in peripheral inflammation; b) hyperammonemia induces inflammation and neuroinflammation, which lead to cognitive and motor impairment. c) peripheral inflammation induces neuroinflammation, increasing inflammatory factors in cerebellum and hippocampus that alter glutamate and GABA neurotransmission, membrane expression of glutamate and GABA receptors and transporters and extracellular levels of these neurotransmitters. This leads to cognitive and motor impairment. d) plasma extracellular vesicles (EV) from hyperammonemic rats, injected to control rats, induce neuroinflammation and cognitive and motor impairment, supporting that EV play a key role in the transmission of peripheral alterations to the brain and in cognitive and motor impairment.
We have been able to reverse cognitive and motor impairment in rats with hyperammonemia and MHE with different treatments acting on targets identified in the mechanistic studies.
12:30 – 13:00 – Amina Benaicha
TITLE
Abstract:
Time
12.06.2025 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Speaker: Patricia Centeno CRUK Scotland Institute Postdoctoral Fellow–R18 Decoding Tumour Permissiveness in the Skin: From Keratinocytes to Melanocytes Abstract: The skin undergoes continuous renewal, relying on stem and progenitor cells to
Event Details
Speaker: Patricia Centeno
CRUK Scotland Institute
Postdoctoral Fellow–R18
Decoding Tumour Permissiveness in the Skin: From Keratinocytes to Melanocytes
Abstract: The skin undergoes continuous renewal, relying on stem and progenitor cells to maintain its barrier function. Over time, multiple oncogenic mutations accumulate, yet the skin often tolerates them without progressing to malignancy. The mechanisms underlying this selective tolerance across different cellular populations remain poorly understood.
In this talk, I will explore how MAPK pathway activation rewires the transcriptional network to generate permissive or non-permissive microenvironments for tumour initiation. First, I will talk about cutaneous squamous cell carcinoma (cSCC), a cancer derived from the keratinocytes. Using genetically engineered mouse models, we investigated the aetiology of rapidly developing cSCC observed in melanoma patients treated with BRAF inhibitors.
Our studies reveal distinct tumour-primed and tumourresistant keratinocyte populations and identify the pioneer ranscription factor SOX2 as a key regulator of this differential response.
In the second part, I will shift focus to melanoma, arising from melanocytes, which co-inhabit the epidermis with keratinocytes. I will present unpublished data regarding melanocyte-keratinocyte crosstalk during melanoma onset.
Preliminary data suggest that neurotrophic signalling and axon guidance pathways contribute to a neuron-like mode of communication that facilitates melanoma initiation. These results open new avenues of research at the interface of neuro and cancer sciences.
Time
13.06.2025 11:00 - 12:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Title: Development of relevant preclinical models and polypeptide-based combination therapies for advanced prostate cancer Autor: Antoni Serrano Marti Abstract: Prostate cancer (PCa) often progresses from localized disease to castration-resistant form (CRPC)
Event Details
Title: Development of relevant preclinical models and polypeptide-based combination therapies for advanced prostate cancer
Autor: Antoni Serrano Marti
Abstract: Prostate cancer (PCa) often progresses from localized disease to castration-resistant form (CRPC) within five years in 20% of cases due to the reactivation of androgen receptor (AR) expression. CRPC development includes transitions from prostatic intraepithelial neoplasia to metastatic CRPC (mCRPC), with 65-75% of mCRPC cases leading to bone metastases, which complicates prognosis and treatment. Early-stage PCa treatment primarily employs prostatectomy and radiotherapy (RT); however, advanced forms lack effective treatments, with CRPC remaining highly lethal. Poly(ADP-ribose) polymerase inhibitors (PARPi) represent a promising targeted therapy for CRPC, particularly for patients with homologous recombination repair (HRR) deficiencies (e.g., BRCA1/BRCA2 mutations); however, clinical challenges (e.g., resistance mechanisms and side effects) hinder their efficacy. Combination therapies involving traditional treatment approaches (RT, abiraterone acetate (Abi), or docetaxel (Dtx)) combined with PARPi offer improved outcomes by driving synthetic lethality in HR-deficient cells. Despite their potential, combination therapy-based approaches face issues such as toxicity, antagonistic interactions and resistances. Nanomedicine offers solutions to some of these challenges, providing controlled drug delivery through passive and active targeting, improving bioavailability, and reducing side effects.
This research focuses on developing and characterizing a bone metastatic PCa model and evaluating the effects of nanomedicine-based therapies; furthermore, we evaluated the effects of PARPi-based combination therapies in vitro in 2D and 3D models and ultimately in vivo to optimize therapeutic outcomes in advanced PCa.
We established and characterized a bone metastatic PCa model, successfully applying this model to develop and evaluate nanomedicine-based therapeutics and combination therapies. We established and characterized novel 3D PCa models, from more straightforward (homospheroids) to more complex (heterospheroids), with the latter better mimicking tumor-stroma interactions. The 3D in vitro models and in vivo platforms effectively recapitulated TME complexity and PCa heterogeneity, providing valuable insights into therapeutic responses and resistance mechanisms. We synthesized and evaluated nanomedicinal forms of traditional therapeutics, demonstrating their potential to enhance drug delivery, reduce toxicity, and improve treatment efficacy. Furthermore, we investigated PARPi-based combination therapy with RT and Abi, highlighting synergistic effects.
Our integrated approach of molecular, preclinical, and therapeutic innovations offers promising approaches for optimizing advanced PCa treatment. We hope the routine use of these advanced models, which mirror the TME and PCa heterogeneity, will improve the development pipeline for nanomedicines and combination therapies, accelerating their clinical translation and enhancing patient outcomes.
Time
13.06.2025 11:00 - 14:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Title: Obtaining and characterising consensus transcriptional profiles for understanding the progression and severity of spinal cord injury. Autor: Rubén Grillo Risco Directors: Victoria Moreno Manzano, Marta R Hidalgo García, Francisco García
Event Details
Title: Obtaining and characterising consensus transcriptional profiles for understanding the progression and severity of spinal cord injury.
Autor: Rubén Grillo Risco
Directors: Victoria Moreno Manzano, Marta R Hidalgo García, Francisco García García
Abstract: Spinal cord injury (SCI) is a devastating condition that leads to motor, sensory, and autonomic dysfunction. Current therapeutic options remain limited,
emphasizing the need for a comprehensive understanding of the underlying SCI-associated molecular mechanisms. This study characterized distinct SCI
phases and severities at the gene and functional levels, focusing on biomarker gene identification. Our approach involved a systematic review, individual
transcriptomic analysis, gene meta-analysis, and functional characterization. We compiled a total of fourteen studies with 273 samples, leading to the
identification of severity- and phase-specific biomarker genes that allow the precise classification of transcriptomic profiles. We investigated the potential
transferability of severity-specific biomarkers and identified a twelve-gene signature that predicted injury prognosis from human blood samples. We
also report the development of MetaSCI-app – an interactive web application designed for researchers – that allows the exploration and visualization of all
generated results (https://metasci-cbl.shinyapps.io/metaSCI). Overall, we present a transcriptomic reference and provide a comprehensive framework for assessing
SCI considering severity and time perspectives, all integrated into a user-friendly tool.
Time
20.06.2025 12:30 - 14:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
more
events
July 2025
03jul12:0013:00SEMINAR: Anna Labernadie / Salvador Meseguer
Event Details
12:00 – 12:30 – Anna Labernadie TITLE Abstract: 12:30 – 13:00 – Salvador Meseguer TITLE Abstract:
Event Details
12:00 – 12:30 – Anna Labernadie
TITLE
Abstract:
12:30 – 13:00 – Salvador Meseguer
TITLE
Abstract:
Time
03.07.2025 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain