UPCOMING EVENTS
SHARING IDEAS AND RESEARCH FINDINGS



UPCOMING EVENTS
SHARING IDEAS AND RESEARCH FINDINGS
OUR UPCOMING
EVENTS
We are working towards becoming a reference center for knowledge, education, and scientific training in Valencia. One way we are achieving this is by regularly holding public events and strengthening our connections with local educational and civic entities. Hence, we offer an ample calendar of specific events designed both for the general public and for the wider scientific community.
this
month
november 2023
16nov12:0013:00SEMINAR: Jaime Navarro / Blanca Escriche
Event Details
12:00 – 12:30 Jaime Navarro Pérez Role of Pla2g6 in adipocytes differentiation and function Obesity is a significant risk factor for metabolic and cardiovascular complications. While most research
Event Details
12:00 – 12:30 Jaime Navarro Pérez
Role of Pla2g6 in adipocytes differentiation and function
Obesity is a significant risk factor for metabolic and cardiovascular complications. While most research aims to understand why obese people develop comorbidities, our lab investigates the opposite paradigm, why some obese people are resilient to develop comorbidities. One of the most widely accepted hypotheses about adipose tissue dysfunction in obese people is the adipose tissue expandability hypothesis. During the formation of adipose tissue (adipogenesis), alterations occur in the progenitors that prevent the cells from increasing in number (hyperplasia), and therefore increase in size (hypertrophy), favouring a state of chronic inflammation and insulin resistance, which favours the development of associated comorbidities. Hence, to understand the molecular mechanisms uncoupling excess adiposity from the development of metabolic complications we will characterise the role of the candidate gene Pla2g6, previously identified in a genome-wide cross-phenotype meta-analysis of adiposity-cardiometabolic trait pairs, in adipocyte differentiation and function. To address this, firstly, we performed a gene expression profiling of Pla2g6 using the GEO repository to look at the expression levels in physiological and pathophysiological conditions. In in vitro datasets, we observed that Pla2g6 expression increases along the differentiation from preadipocytes to mature adipocytes. In a human adipose tissue dataset, its expression is significantly decreased in white adipose tissue from metabolically unhealthy human individuals vs metabolically healthy and lean controls. Similarly, in vivo, in mice, the profiling of Pla2g6 reveals its upregulation in white adipose tissue of 4-weeks ob/ob mice group (healthy obesity model); and a generalised downregulation in the white adipose tissue of a mouse model of impaired white adipose tissue expansion impairment (POKO mice) vs the wild-type group. Next, we have developed an in vitro model of adipogenesis, to study the effects of the loss of Pla2g6 in the differentiation process, using a CRISPR-Cas9 KO approach in the 3T3L1 pre-adipocyte cell line. Our findings show that Pla2g6-KO cells show a significantly reduced differentiation potential vs control. They display a decreased capability to accumulate lipids, reduced expression of adipogenic genes (i.e Pparg2 and aP2), maturation markers (i.e Plin1) as well as de novo lipogenesis genes (i.e Srebp1c, Scd1 and Fasn). The depletion of Pla2g6 also affected the proliferation and morphology of the cells which shape is different from the control ones. Altogether, our research provides a potential novel role for Pla2g6 in adipose tissue expansion and further characterization is needed to understand its exact function.
12:30 – 13:00 Blanca Escriche Navarro
New therapeutic strategies targeting senescent cells
Cellular senescence is an irreversible process of cell cycle arrest triggered by various stress signals to prevent the propagation of damaged cells. However, the persistent presence of senescent cells (SCs) can promote a dysregulated inflammatory environment that can result in tissue dysfunction, contributing to the onset and progression of multiple age-related disorders. In this context, the elimination of SCs has emerged as an effective therapeutic strategy. However, a challenging factor is that the senescent phenotype is highly heterogeneous, which hinders the discovery of a universal and robust senescence biomarker and contributes to the fact that developed senescence therapies have a highly variable response in the clinic, with off-target toxic effects. Here, we have developed two nanodevices loaded with the senolytic navitoclax and a BODIPY-based photosensitizer for selective removal of SCs targeting different biomarkers of cellular senescence, such as overexpression of the cell membrane receptor dipeptidyl peptidase-4 (DPP4), matrix metalloproteinase-3 (MMP-3) and senescence-associated β-galactosidase (SA-β-gal). In vitro and in vivo results demonstrate the potential application of the three developed systems by achieving a selective elimination of SCs with clinical relevance.
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
Event Details
Jornada Internacional sobre la Enfermedad de Wilson / XIV Jornada Científica y de Convivencia de la Enfermedad de Wilson 25 y 26 de noviembre de 2023 Bombas Gens Centre d’Art (Valencia, España) Organizada
Event Details
Jornada Internacional sobre la Enfermedad de Wilson / XIV Jornada Científica y de Convivencia de la Enfermedad de Wilson
25 y 26 de noviembre de 2023
Bombas Gens Centre d’Art (Valencia, España)
Organizada por la Asociación Española de Familiares y Enfermos de Wilson, la Fundació Per Amor a l’Art y el Centro de Investigación Príncipe Felipe.
Si deseas acudir, escribe a: asociaciondewilson@gmail.com
Más información:
https://enfermedaddewilson.org/jornada-internacional-cientifica-y-de-convivencia-sobre-la-enfermedad-de-wilson/
#enfermedaddewilson
Asociación Española de Familiares y Enfermos de Wilson
Administración.
Time
25 (Saturday) 09:30 - 26 (Sunday) 13:30
Location
Bombas Gens Centre d'Art
Av. de Burjassot, 54-56
Organizer
30nov12:3013:30FBR: Eva Hernando-Monge
Event Details
Mechanisms of neural mimicry during melanoma metastasis Speaker: Eva Hernando-Monge Institution: Department of Pathology, NYU Langone Health, New York Place: Jerónimo Forteza conference room, CIPF Abstract: For most cancer types, metastatic
Event Details
Mechanisms of neural mimicry during melanoma metastasis
Speaker: Eva Hernando-Monge
Institution: Department of Pathology, NYU Langone Health, New York
Place: Jerónimo Forteza conference room, CIPF
Abstract: For most cancer types, metastatic spread of tumor cells from a primary location to distal organs throughout the body is the pivotal determinant of poor outcomes for patients. Roughly 90% of cancer deaths are attributable to metastasis, yet our understanding of the mechanisms responsible for metastatic spread is limited. Melanoma is an excellent model to investigate the mechanistic bases of metastasis. Unlike other cancers, melanoma metastasis frequently occurs from tiny primary tumors that are measured in millimeters, reflective of melanoma’s highly aggressive nature. However, the cellular and molecular mechanisms responsible for this phenotype are incompletely understood. The current staging system is insufficient at predicting which primary melanomas will recur and metastasize. To date, no genetic signatures or combinations have been found that can accurately predict metastatic behavior.
Our laboratory is studying the contributions of non-genetic alterations – including epigenetic programs and non-coding RNA — to the aggressive behavior of melanoma. We have found that melanoma metastatic potential often results from retention or re-activation of transcriptional programs characteristic of neural crest cells, the melanocyte cell of origin and a multipotent and highly migratory cell type. We are also investigating the molecular basis for melanoma’s notorious ability to adapt to the brain microenvironment. Our studies are revealing novel drivers of melanoma maintenance and progression, which might become novel prognostic or therapeutic targets.
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Thursday) 12:30 - 13:30
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
next
month
december 2023
14dec12:0013:00SEMINAR: Alihamze Fathinajabadi / To be confirmed
Event Details
12:00 – 12:30 Alihamze Fathinajabadi Title Abstract 12:30 – 13:00 To be confirmed Title Abstract
Event Details
12:00 – 12:30 Alihamze Fathinajabadi
Title
Abstract
12:30 – 13:00 To be confirmed
Title
Abstract
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
15dec13:0014:00FBR: Prof. Simon Matoori Repurposing drug delivery systems for diagnostics
Event Details
Repurposing drug delivery systems for diagnostics Speaker: Prof. Joern Dengjel Institution: Faculté de Pharmacie, Université de Montréal, Montréal, Canada Place: Jerónimo Forteza conference room, CIPF Abstract: In the last
Event Details
Repurposing drug delivery systems for diagnostics
Speaker: Prof. Joern Dengjel
Institution: Faculté de Pharmacie, Université de Montréal, Montréal, Canada
Place: Jerónimo Forteza conference room, CIPF
Abstract:
In the last two decades, a number of drug delivery systems were repurposed for diagnostic applications. Traditional uses of diagnostic delivery systems are nanocarriers of diagnostic cargo (e.g., contrast agents) with controlled release kinetics or active targeting properties. In this seminar, I will demonstrate how established delivery systems can be used for diagnostics in less conventional ways. First, I will present the development of an enzyme-loaded vesicular reaction compartment for the quantification of lactate in whole blood. Isolating the lactate-sensing reaction in the liposomal lumen allowed this reaction to occur in whole blood as interfering substances were incapable of crossing the membrane. This vesicular reaction compartment forms the basis of a novel blood lactate assay for bedside use in sepsis. The fluorescence assay was tested in fresh human blood in an Institutional Review Board-approved study and successfully combined with a portable fluorometer. This system highlighted how the selectively permeable membrane of liposomes could be utilized to isolate an enzymatic reaction in order to enable it in a prohibiting matrix. Second, I will present the development of a series of novel non-releasing hydrogels for diagnostic applications. Hydrogels are widely used in tissue engineering and drug delivery, and their localization is tied to their function. As means for hydrogel localization in the body are limited, we developed a new and broadly applicable method to track hydrogels by encapsulating a clinically used oil-based contrast agent. This non-releasing system was visualized in mice using computed tomography. Another example of a non-releasing hydrogel is a pH-sensing diagnostic wound dressing for chronic wounds. Hydrogels loaded with pH-sensitive fluorescent microparticles were developed and sensed the pH in a clinically relevant range on dorsal mouse wounds. The dye was highly retained on microparticles in the presence of biological fluids to minimize the risk of wound exposure to the dye. These liposomal and hydrogel systems highlight the high versatility and usefulness of drug delivery systems for diagnostic applications.
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Friday) 13:00 - 14:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
more
events
january 2024
18jan12:0013:00SEMINAR: Javier Martínez / Carlos Camps
Event Details
12:00 – 12:30 Javier Martínez Latorre Title Abstract 12:30 – 13:00 Carlos Camps Title Abstract
Event Details
12:00 – 12:30 Javier Martínez Latorre
Title
Abstract
12:30 – 13:00 Carlos Camps
Title
Abstract
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
february 2024
22feb12:0013:00SEMINAR: Verónica Llorens / Jose Luís López
Event Details
12:00 – 12:30 Verónica Llorens Title Abstract 12:30 – 13:00 Jose Luís López Title Abstract
Event Details
12:00 – 12:30 Verónica Llorens
Title
Abstract
12:30 – 13:00 Jose Luís López
Title
Abstract
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
april 2024
11apr12:0013:00SEMINAR: Edna Ripollés / Jesús Alejandro Alzate
Event Details
12:00 – 12:30 Edna Ripollés Title Abstract 12:30 – 13:00 Jesús Alejandro Alzate Title Abstract
Event Details
12:00 – 12:30 Edna Ripollés
Title
Abstract
12:30 – 13:00 Jesús Alejandro Alzate
Title
Abstract
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
may 2024
16may12:0013:00SEMINAR: To be confirmed / Regina Rodrigo
Event Details
12:00 – 12:30 To be confirmed Abstract 12:30 – 13:00 Regina Rodrigo Title Abstract
Event Details
12:00 – 12:30 To be confirmed
Abstract
12:30 – 13:00 Regina Rodrigo
Title
Abstract
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Organizer
june 2024
20jun12:0013:00SEMINAR: Mª del Mar Sánchez / Mª Ángeles Juanes
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín Abstract 12:30 – 13:00 Mª Ángeles Juanes Title Abstract
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín
Abstract
12:30 – 13:00 Mª Ángeles Juanes
Title
Abstract
Time
(Thursday) 12:00 - 13:00
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain