PRÓXIMOS EVENTOS
COMPARTIENDO IDEAS Y RESULTADOS DE INVESTIGACIÓN
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PRÓXIMOS EVENTOS
COMPARTIENDO IDEAS Y RESULTADOS DE INVESTIGACIÓN
NUESTROS PRÓXIMOS EVENTOS
EVENTOS
Trabajamos para ser una referencia en el conocimiento, la difusión y la formación científica en Valencia, realizando regularmente eventos públicos y fortaleciendo las conexiones con entidades educativas y cívicas locales. Ofrecemos un calendario de eventos específicos para el público en general y para la comunidad científica.
este
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July 2024
03jul12:0013:00SEMINAR: Mª del Mar Sánchez / Mohammed M. Anwar
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín Optogenetic stimulation of stem cell grafts for the treatment of spinal cord injuries Spinal Cord Injury (SCI) disrupts the communication between the brain and
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín
Optogenetic stimulation of stem cell grafts for the treatment of spinal cord injuries
Spinal Cord Injury (SCI) disrupts the communication between the brain and the spinal circuits responsible for a variety of neurological functions and coordinated movement, leading to motor, sensory and autonomic dysfunctions. Neural progenitor cells (NPC) emerge as one of the most promising treatments for SCI due to its multifaceted capabilities in replacing host cells (Kadoya et al., 2016), providing trophic support, modulating neuroinflammation, bridging lesions, thereby reinstating neuronal circuitry and connectivity. However, several challenges remain, such as improving graft survival, directing NPC differentiation towards desires neuronal lineages and establishing functional synaptic connections (Fischer et al., 2020).
Optogenetics has been extensively used for elucidating circuit dynamics and graft-host connectivity (Ceto et al., 2020). However, its immense potential for activating stem cell grafts remains largely unexplored. The application of optogenetics to precisely modulate stem cell graft activity in vivo presents a novel and noninvasive approach for manipulating cell behaviour following stem cell transplant after SCI. This strategy holds great promise for advancing our understanding and enhancing therapeutic interventions for SCI. Therefore, our research proposes the use of optogenetic to precisely modulate spinal cord-derived NPCs expressing the light-sensitive cation channel channelrhodopsin-2 (ChR2), under ubiquitous promoter, transplanted into an in vivo model of spinal cord injury. Our findings demonstrated that optogenetic stimulation of NPCs enhance early functional locomotor recovery following a T8 hemisection in rats by increasing graft survival, modifying graft identity and activity. Additionally, optostimulation of NPC has been shown to influence astrocyte reactivity at the lesion border, thereby improving the neuroprotective properties of stem cells. Furthermore, considering the critical role of excitatory synapsis in functional recovery after SCI (Kathe et al., 2022), we further aim to directly excite human neural stem cell (hNSC) by expressing the ChR2 under CAMKII promoter in vitro. Our results revealed that direct optogenetic stimulation effectively increase human neural stem cell activity and synchrony in cell culture, highlighting its potential as a promising strategy for further testing in a clinically relevant model of SCI. This approach holds promise for providing a more excitatory neural landscape to influencing the establishment of crucial new connections at the lesion site, thereby leading to improved locomotor function.
12:30 – 13:00 Mohammed M. Anwar
Title
Abstract
Time
03.07.2024 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
04jul12:3013:30FBR: Maria MittelbrunnDecoding the contribution of the immune system to aging
Event Details
Decoding the contribution of the immune system to aging Speaker: Maria Mittelbrunn Herrero Institution: Inmunometabolism & Inflammation Lab, Centro de Biología Molecular Severo Ochoa, Madrid, Spain Place: Jerónimo Forteza conference room, CIPF
Event Details
Decoding the contribution of the immune system to aging
Speaker: Maria Mittelbrunn Herrero
Institution: Inmunometabolism & Inflammation Lab, Centro de Biología Molecular Severo Ochoa, Madrid, Spain
Place: Jerónimo Forteza conference room, CIPF
Abstract: To investigate the consequences of the aging of the immune system, we have induced age-associated mitochondrial dysfunction prematurely in T cell. Targeting mitochondrial function in T cells recapitulates metabolic, phenotypic and functional features of aged T cells, including susceptibility to infections and premature inflammaging. We found that inducing age-associated mitochondrial decline in T lymphocytes, does not only cause an immunometabolic dysfunction that drives T cell senescence, but actually causes a general, body-wide deterioration of health with multiple aging-related features, including metabolic, musculoskeletal, cardiovascular and cognitive alterations, altogether resulting in premature death. Thus, premature aging of T lymphocytes may be ‘contagious’, driving a generalized acceleration of aging throughout multiple organ systems. Our results place the metabolism of T cells at the crossroad between inflammation, senescence and aging, highlighting that immunometabolism can be a therapeutic target to delay aging. This presentation will decode the molecular mechanism by which mitochondrial defective T cells contribute to inflammaging and age-related diseases and will discuss novel therapeutic opportunities to promote healthy aging.
Funding: This study was supported by the European Regional Development Fund (ERDF) and the European Commission through H2020-EU.1.1, European Research Council grant ERC-2021-CoG 101044248-LetTBe
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-07/2024 and CIAORG/2023/147
Time
04.07.2024 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Title: Machine Learning en Resonancia Magnética. Describiendo la Fisiopatología del Dolor Lumbar Autor: Jhon Jairo Saenz Gamboa Director: Dra. María de la Iglesia Vayá Abstract:
Event Details
Title: Machine Learning en Resonancia Magnética. Describiendo la Fisiopatología del Dolor Lumbar
Autor: Jhon Jairo Saenz Gamboa
Director: Dra. María de la Iglesia Vayá
Abstract:
Time
12.07.2024 11:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
THE ROLE OF GUT MICROBIOTA IN HEALTH: FROM PROTECTION AGAINST OPPORTUNISTIC PATHOGENS TO MICROBIOTA-HOST METABOLIC CROSSTALK Ana Djukovic, Memorial Sloan Kettering Cancer Center, New York Julio 29 – 12:00h Salón Forteza, CIPF
Event Details
THE ROLE OF GUT MICROBIOTA IN HEALTH: FROM PROTECTION AGAINST OPPORTUNISTIC PATHOGENS TO MICROBIOTA-HOST METABOLIC CROSSTALK
Ana Djukovic, Memorial Sloan Kettering Cancer Center, New York
Julio 29 – 12:00h
Salón Forteza, CIPF
Abstract:
Time
29.07.2024 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
más
eventos
September 2024
October 2024
Time
17.10.2024 09:00 - 18.10.2024 18:30(GMT+02:00)
Location
Palacio de Congresos de Alicante
Organizer
17oct12:3013:30FBR: Ivan Dikic Goethe
Event Details
Title Speaker: Ivan Dikic Goethe Institution: Molecular Signaling Lab, Goethe University Frankfurt, Frankfurt, Germany Place: Jerónimo Forteza conference room, CIPF Abstract: PATROCINADO POR: With support
Event Details
Title
Speaker: Ivan Dikic Goethe
Institution: Molecular Signaling Lab, Goethe University Frankfurt, Frankfurt, Germany
Place: Jerónimo Forteza conference room, CIPF
Abstract:
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-07/2024 and CIAORG/2023/147
Time
17.10.2024 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
November 2024
14nov12:3013:30FBR: Lea-Laetitia Pontani
Event Details
Title Speaker: Lea-Laetitia Pontani Institution: Laboratoire Jean Perrin, Sorbonne Université, Paris, France Place: Jerónimo Forteza conference room, CIPF Abstract: PATROCINADO POR: With support from the
Event Details
Title
Speaker: Lea-Laetitia Pontani
Institution: Laboratoire Jean Perrin, Sorbonne Université, Paris, France
Place: Jerónimo Forteza conference room, CIPF
Abstract:
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-07/2024 and CIAORG/2023/147
Time
14.11.2024 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
December 2024