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November
Time
04.11.2024 15:00 - 06.11.2024 14:00(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
07nov12:3013:30FBR: Tambet Teesalu
Event Details
Title Speaker: Dr. Tambet Teesalu Institution: Laboratory of Precision and Nanomedicine, University of Tartu, Estonia Place: Jerónimo Forteza conference room, CIPF Abstract: PATROCINADO POR:
Event Details
Title
Speaker: Dr. Tambet Teesalu
Institution: Laboratory of Precision and Nanomedicine, University of Tartu, Estonia
Place: Jerónimo Forteza conference room, CIPF
Abstract:
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-07/2024 and CIAORG/2023/147
Time
07.11.2024 12:30 - 13:30(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
13nov(nov 13)17:0015(nov 15)15:30XVI SDDNSpanish Drug Discovery Network
Time
13.11.2024 17:00 - 15.11.2024 15:30(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Emulsions as a tool to study tissue mechanics in vitro and in vivo Speaker: Lea-Laetitia Pontani Institution: Jean Perrin Laboratory, Sorbonne University, Paris, France Place: Jerónimo Forteza conference room, CIPF Abstract: We
Event Details
Emulsions as a tool to study tissue mechanics in vitro and in vivo
Speaker: Lea-Laetitia Pontani
Institution: Jean Perrin Laboratory, Sorbonne University, Paris, France
Place: Jerónimo Forteza conference room, CIPF
Abstract: We use biomimetic emulsions to study the physical basis of collective remodeling during development. Indeed, emulsions made of oil droplets in water can be tailored to mimic the minimal mechanical and adhesive properties of cells in biological tissues. This reductionist approach allows us to study the mechanical properties of tissues in a simplified framework in which the inherent biological complexity due to intracellular regulations is bypassed.
We focus on the interplay between adhesion and mechanical forces and how this interplay regulates the emergence of tissue architecture during morphogenesis. To do so, we study the elasto-plasticity of these emulsions as a function of interdroplet adhesion through microfluidici approaches. We show that adhesion alone is able to guide the emergence of structuration in adhesive emulsions when they are submitted to mechanical constraints.
In parallel to this in vitro approach, droplets can be used to probe cellular forces inside biological tissues. Indeed, droplets can be made soft enough to probe forces exerted by cells or tissues: knowing their surface tension, it is then possible to quantify the local exerted stress from their observed deformation. We are currently using droplets to unravel the role of the extracellular matrix in the mechanical coupling of cells and tissues during morphogenesis.
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-07/2024 and CIAORG/2023/147
Time
14.11.2024 12:30 - 13:30(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
21nov12:0013:00Xavier TrepatBottom-up mechanobiology: from cell sheets to organoids
Event Details
BOTTOM-UP MECHANOBIOLOGY: FROM CELL SHEETS TO ORGANOIDS Xavier Trepat, ICREA Institute for Bioengineering of Catalonia, Barcelona, Spain November 21 – 12:00h Salón Forteza, CIPF Abstract: Epithelial sheets form specialized 3D structures
Event Details
BOTTOM-UP MECHANOBIOLOGY: FROM CELL SHEETS TO ORGANOIDS
Xavier Trepat, ICREA Institute for Bioengineering of Catalonia, Barcelona, Spain
November 21 – 12:00h
Salón Forteza, CIPF
Abstract: Epithelial sheets form specialized 3D structures suited to their physiological roles, such as branched alveoli in the lungs, tubes in the kidney, and villi in the intestine. To generate and maintain these structures, epithelia must undergo complex 3D deformations across length and time scales. How epithelial shape arises from active stresses, viscoelasticity and luminal pressure remains poorly understood. I will present different approaches to study the mechanobiology of epithelial shape from the bottom up. I will discuss new technologies to design epithelia of arbitrary size and geometry and to subject them to controlled mechanical deformations in 3D. I will show that monolayers exhibit superelastic behavior when stretch is applied and that they readily buckle when compressed. We use this phenomenology and a 3D vertex model to rationally direct spontaneous pattern formation, and hence engineer tissue folding. I will also present our recent advances to understand the mechanobiology of intestinal organoids. We show that these organoids exhibit a non-monotonic stress distribution that defines mechanical and functional compartments. Finally, I will discuss how intestinal mechanobiology is derailed in patient-derived colorectal cancer organoids.
Time
21.11.2024 12:00 - 13:00(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
25nov12:3013:30FBR: Irene Casanova Salas
Event Details
Title Speaker: Dr. Irene Casanova Salas Institution: Prostate Cancer Translational Research Team. Vall Hebron Institute of Oncology (VHIO). Barcelona, Spain. Place: Jerónimo Forteza conference room, CIPF Abstract: PATROCINADO POR:
Event Details
Title
Speaker: Dr. Irene Casanova Salas
Institution: Prostate Cancer Translational Research Team. Vall Hebron Institute of Oncology (VHIO). Barcelona, Spain.
Place: Jerónimo Forteza conference room, CIPF
Abstract:
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-07/2024 and CIAORG/2023/147
Time
25.11.2024 12:30 - 13:30(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
December
Event Details
Event Details
Time
09.09.2024 15:00 - 22.11.2024 19:00(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Event Details
Time
14.10.2024 15:00 - 13.12.2024 19:00(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Time
04.11.2024 15:00 - 06.11.2024 14:00(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
07nov12:3013:30FBR: Tambet Teesalu
Event Details
Title Speaker: Dr. Tambet Teesalu Institution: Laboratory of Precision and Nanomedicine, University of Tartu, Estonia Place: Jerónimo Forteza conference room, CIPF Abstract: PATROCINADO POR:
Event Details
Title
Speaker: Dr. Tambet Teesalu
Institution: Laboratory of Precision and Nanomedicine, University of Tartu, Estonia
Place: Jerónimo Forteza conference room, CIPF
Abstract:
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-07/2024 and CIAORG/2023/147
Time
07.11.2024 12:30 - 13:30(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
13nov(nov 13)17:0015(nov 15)15:30XVI SDDNSpanish Drug Discovery Network
Time
13.11.2024 17:00 - 15.11.2024 15:30(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Emulsions as a tool to study tissue mechanics in vitro and in vivo Speaker: Lea-Laetitia Pontani Institution: Jean Perrin Laboratory, Sorbonne University, Paris, France Place: Jerónimo Forteza conference room, CIPF Abstract: We
Event Details
Emulsions as a tool to study tissue mechanics in vitro and in vivo
Speaker: Lea-Laetitia Pontani
Institution: Jean Perrin Laboratory, Sorbonne University, Paris, France
Place: Jerónimo Forteza conference room, CIPF
Abstract: We use biomimetic emulsions to study the physical basis of collective remodeling during development. Indeed, emulsions made of oil droplets in water can be tailored to mimic the minimal mechanical and adhesive properties of cells in biological tissues. This reductionist approach allows us to study the mechanical properties of tissues in a simplified framework in which the inherent biological complexity due to intracellular regulations is bypassed.
We focus on the interplay between adhesion and mechanical forces and how this interplay regulates the emergence of tissue architecture during morphogenesis. To do so, we study the elasto-plasticity of these emulsions as a function of interdroplet adhesion through microfluidici approaches. We show that adhesion alone is able to guide the emergence of structuration in adhesive emulsions when they are submitted to mechanical constraints.
In parallel to this in vitro approach, droplets can be used to probe cellular forces inside biological tissues. Indeed, droplets can be made soft enough to probe forces exerted by cells or tissues: knowing their surface tension, it is then possible to quantify the local exerted stress from their observed deformation. We are currently using droplets to unravel the role of the extracellular matrix in the mechanical coupling of cells and tissues during morphogenesis.
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-07/2024 and CIAORG/2023/147
Time
14.11.2024 12:30 - 13:30(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
21nov12:0013:00Xavier TrepatBottom-up mechanobiology: from cell sheets to organoids
Event Details
BOTTOM-UP MECHANOBIOLOGY: FROM CELL SHEETS TO ORGANOIDS Xavier Trepat, ICREA Institute for Bioengineering of Catalonia, Barcelona, Spain November 21 – 12:00h Salón Forteza, CIPF Abstract: Epithelial sheets form specialized 3D structures
Event Details
BOTTOM-UP MECHANOBIOLOGY: FROM CELL SHEETS TO ORGANOIDS
Xavier Trepat, ICREA Institute for Bioengineering of Catalonia, Barcelona, Spain
November 21 – 12:00h
Salón Forteza, CIPF
Abstract: Epithelial sheets form specialized 3D structures suited to their physiological roles, such as branched alveoli in the lungs, tubes in the kidney, and villi in the intestine. To generate and maintain these structures, epithelia must undergo complex 3D deformations across length and time scales. How epithelial shape arises from active stresses, viscoelasticity and luminal pressure remains poorly understood. I will present different approaches to study the mechanobiology of epithelial shape from the bottom up. I will discuss new technologies to design epithelia of arbitrary size and geometry and to subject them to controlled mechanical deformations in 3D. I will show that monolayers exhibit superelastic behavior when stretch is applied and that they readily buckle when compressed. We use this phenomenology and a 3D vertex model to rationally direct spontaneous pattern formation, and hence engineer tissue folding. I will also present our recent advances to understand the mechanobiology of intestinal organoids. We show that these organoids exhibit a non-monotonic stress distribution that defines mechanical and functional compartments. Finally, I will discuss how intestinal mechanobiology is derailed in patient-derived colorectal cancer organoids.
Time
21.11.2024 12:00 - 13:00(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
25nov12:3013:30FBR: Irene Casanova Salas
Event Details
Title Speaker: Dr. Irene Casanova Salas Institution: Prostate Cancer Translational Research Team. Vall Hebron Institute of Oncology (VHIO). Barcelona, Spain. Place: Jerónimo Forteza conference room, CIPF Abstract: PATROCINADO POR:
Event Details
Title
Speaker: Dr. Irene Casanova Salas
Institution: Prostate Cancer Translational Research Team. Vall Hebron Institute of Oncology (VHIO). Barcelona, Spain.
Place: Jerónimo Forteza conference room, CIPF
Abstract:
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-07/2024 and CIAORG/2023/147
Time
25.11.2024 12:30 - 13:30(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
27nov10:0012:00A Practical Lipidomic Data Analysis SessionBIOINFORMATICS TRAINING COURSES 2024
Event Details
Event Details
Time
27.11.2024 10:00 - 12:00(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
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Josep Forment and Paola Marco-Casanova
Targeting the DNA damage response in cancer treatment Speaker: Josep Forment,...
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