Cytoskeletal Dynamics In Cell Migration And Cancer Invasion

Our goal is to understand the mechanistic basis of coordinated cytoskeleton remodelling events in collective cell migration and cancer invasion, and link those to normal gut homeostasis and/or specific disease phenotypes. Our lab exploits specific separation-of-function mutants in a multi-pronged approach across scales, from reconstituted proteins to cellular models, including 3D intestinal organoids. We use a range of techniques from biochemistry using single-molecule assays to genetics, proteomics, cell biology and cell imaging, including quantitative advanced live imaging and super-resolution microscopy. The ultimate goal is to find novel biomarkers for early detection and assist in the design for personalised therapies. Our research will advance an emerging field by defining molecular mechanisms that underlie a host of fundamental biological processes and identify genetic mutations that will serve as signatures for early prevention of human diseases.