The Joint Unit on Neurological Impairment CIPF-INCLIVA performs basic and translational research on cognitive, motor, sleep and circadian rhythms alterations in different pathological situations, including: minimal and clinical hepatic encephalopathy (HE), hyperammonemia and developmental exposure to food and environmental contaminants. We also apply our wide range of methodologies to other pathological situations. The aims are:
In animal models:
- Unveil the molecular mechanisms leading to neurological impairment.
- Identify new therapeutic targets for its treatment.
- Design and assess new therapeutic procedures to reverse neurological impairment.
In patients:
- Study the mechanisms, diagnosis and treatment of neurological impairment.
- Identify early diagnostic procedures for neurological impairment.
- Bring to the clinic the diagnostic procedures identified.
Presentation
Get to know us better
Research Staff
The people who make it all possible
Carmina Montoliu Felix
Alejandra Hernández Hernández
ahernandezh@cipf.es
Publications
Our scientific contributions
Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-kappa B pathway
T. BALZANO, Y. ARENAS, S. DADSETAN, J. FORTEZA, S. GIL-PEROTIN, L. CUBAS-NUNEZ, B. CASANOVA, F. GRACIA, N. VARELA-ANDRES, C. MONTOLIU, M. LLANSOLA and V. FELIPO
Journal of Neuroinflammation, 2020 Feb, DOI: 10.1186/s12974-020-01746-z, Vol. 17, pag. 70-70
Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy
C. SAN MARTIN-VALENZUELA, A. BORRAS-BARRACHINA, J. GALLEGO, A. URIOS, V. MESTRE-SALVADOR, P. CORREA-GHISAYS, M. BALLESTER, D. ESCUDERO-GARCIA, J. TOSCA, C. MONTON, M. RIOS, E. KOSENKO, V. FELIPO, R. TABARES-SEISDEDOS, G. SELVA-VERA and C. MONTOLIU
Journal of Clinical Medicine, 2020 Jul, DOI: 10.3390/jcm9072154, Vol. 9, pag.
Hyperammonemia alters the mismatch negativity in the auditory evoked potential by altering functional connectivity and neurotransmission
R. GARCIA-GARCIA, J. GUERRERO, M. LAVILLA-MIYASATO, J. MAGDALENA, J. ORDONO, M. LLANSOLA, C. MONTOLIU, V. TERUEL-MARTI and V. FELIPO
JOURNAL OF NEUROCHEMISTRY, 2020 Jul, DOI: 10.1111/jnc.14941, Vol. 154, pag. 56-70
Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats
P. IZQUIERDO-ALTAREJOS, A. CABRERA-PASTOR, H. GONZALEZ-KING, C. MONTOLIU and V. FELIPO
Cells, 2020 Mar, DOI: 10.3390/cells9030572, Vol. 9, pag.
The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence.
Kosenko E, Tikhonova L, Alilova G, Urios A and Montoliu C
Journal of Clinical Medicine, 2020 Jan, DOI: 10.3390/jcm9010206, Vol. 9, pag.
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