The Joint Unit on Neurological Impairment CIPF-INCLIVA performs basic and translational research on cognitive, motor, sleep and circadian rhythms alterations in different pathological situations, including: minimal and clinical hepatic encephalopathy (HE), hyperammonemia and developmental exposure to food and environmental contaminants. We also apply our wide range of methodologies to other pathological situations. The aims are:

In animal models:

  1. Unveil the molecular mechanisms leading to neurological impairment.
  2. Identify new therapeutic targets for its treatment.
  3. Design and assess new therapeutic procedures to reverse neurological impairment.

In patients:

  1. Study the mechanisms, diagnosis and treatment of neurological impairment.
  2. Identify early diagnostic procedures for neurological impairment.
  3. Bring to the clinic the diagnostic procedures identified.

Presentation

Get to know us better

Research Staff

The people who make it all possible

Carmina Montoliu Felix

Publications

Our scientific contributions

Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-kappa B pathway
T. BALZANO, Y. ARENAS, S. DADSETAN, J. FORTEZA, S. GIL-PEROTIN, L. CUBAS-NUNEZ, B. CASANOVA, F. GRACIA, N. VARELA-ANDRES, C. MONTOLIU, M. LLANSOLA and V. FELIPO
Journal of Neuroinflammation, 2020 Feb,  DOI:  10.1186/s12974-020-01746-z,  Vol. 17,  pag. 70-70

Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy
C. SAN MARTIN-VALENZUELA, A. BORRAS-BARRACHINA, J. GALLEGO, A. URIOS, V. MESTRE-SALVADOR, P. CORREA-GHISAYS, M. BALLESTER, D. ESCUDERO-GARCIA, J. TOSCA, C. MONTON, M. RIOS, E. KOSENKO, V. FELIPO, R. TABARES-SEISDEDOS, G. SELVA-VERA and C. MONTOLIU
Journal of Clinical Medicine, 2020 Jul,  DOI:  10.3390/jcm9072154,  Vol. 9,  pag. 2154

Hyperammonemia alters the mismatch negativity in the auditory evoked potential by altering functional connectivity and neurotransmission
R. GARCIA-GARCIA, J. GUERRERO, M. LAVILLA-MIYASATO, J. MAGDALENA, J. ORDONO, M. LLANSOLA, C. MONTOLIU, V. TERUEL-MARTI and V. FELIPO
JOURNAL OF NEUROCHEMISTRY, 2020 Jul,  DOI:  10.1111/jnc.14941,  Vol. 154,  pag. 56-70

Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats
P. IZQUIERDO-ALTAREJOS, A. CABRERA-PASTOR, H. GONZALEZ-KING, C. MONTOLIU and V. FELIPO
Cells, 2020 Mar,  DOI:  10.3390/cells9030572,  Vol. 9,  pag. 572

The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence.
Kosenko E, Tikhonova L, Alilova G, Urios A and Montoliu C
Journal of Clinical Medicine, 2020 Jan,  DOI:  10.3390/jcm9010206,  Vol. 9,  pag. 

 

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