Find novel genetic signatures and/or biomarkers for early detection of human diseases.
Our goal is to understand the mechanistic basis of coordinated cytoskeleton remodelling events in collective cell migration and cancer invasion, and link those to normal gut homeostasis and/or specific disease phenotypes. Our lab exploits specific separation-of-function mutants in a multi-pronged approach across scales, from reconstituted proteins to cellular models, including 3D intestinal organoids. We use a range of techniques from biochemistry using single-molecule assays to genetics, proteomics, cell biology and cell imaging, including quantitative advanced live imaging and super-resolution microscopy. The ultimate goal is to find novel biomarkers for early detection and assist in the design for personalised therapies. Our research will advance an emerging field by defining molecular mechanisms that underlie a host of fundamental biological processes and identify genetic mutations that will serve as signatures for early prevention of human diseases.
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The people who make it all possible
Mari Ángeles Juanes Ortiz
Our scientific contributions
Cytoskeletal Control and Wnt Signaling-APC's Dual Contributions in Stem Cell Division and Colorectal Cancer.
Cancers, 2020 Dec,  DOI:  10.3390/cancers12123811,  Vol. 12,  pag.
EB1 Directly Regulates APC-Mediated Actin Nucleation.
Juanes MA, Fees CP, Hoeprich GJ, Jaiswal R and Goode BL
CURRENT BIOLOGY, 2020 Dec,  DOI:  10.1016/j.cub.2020.08.094,  Vol. 30,  pag.
The role of APC-mediated actin assembly in microtubule capture and focal adhesion turnover.
Juanes MA, Isnardon D, Badache A, Brasselet S, Mavrakis M and Goode BL
JOURNAL OF CELL BIOLOGY, 2019 Oct,  DOI:  10.1083/jcb.201904165,  Vol. 218,  pag. 3415-3435
Recruitment of the mitotic exit network to yeast centrosomes couples septin displacement to actomyosin constriction.
Tamborrini D, Juanes MA, Ibanes S, Rancati G and Piatti S
Nature Communications, 2018 Oct,  DOI:  10.1038/s41467-018-06767-0,  Vol. 9,  pag. 4308-4308
Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover.
Juanes MA, Bouguenina H, Eskin JA, Jaiswal R, Badache A and Goode BL
JOURNAL OF CELL BIOLOGY, 2017 Sep,  DOI:  10.1083/jcb.201702007,  Vol. 216,  pag. 2859-2875