Neurological Impairment

(CIPF - INCLIVA) Carmina Montoliu Felix

THE JOINT UNIT ON NEUROLOGICAL IMPAIRMENT CIPF-INCLIVA PERFORMS BASIC AND TRANSLATIONAL RESEARCH ON COGNITIVE, MOTOR, SLEEP AND CIRCADIAN RHYTHMS ALTERATIONS IN DIFFERENT PATHOLOGICAL SITUATIONS, INCLUDING: MINIMAL AND CLINICAL HEPATIC ENCEPHALOPATHY (HE), HYPERAMMONEMIA AND DEVELOPMENTAL EXPOSURE TO FOOD AND ENVIRONMENTAL CONTAMINANTS.

We also apply our wide range of methodologies to other pathological situations. The aims are:

In animal models:

Unveil the molecular mechanisms leading to neurological impairment.
Identify new therapeutic targets for its treatment.
Design and assess new therapeutic procedures to reverse neurological impairment.

In patients:

Study the mechanisms, diagnosis and treatment of neurological impairment.
Identify early diagnostic procedures for neurological impairment.
Bring to the clinic the diagnostic procedures identified.

PRESENTATION

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PUBLICATIONS

OUR SCIENTIFIC CONTRIBUTIONS

Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-kappa B pathway

T. BALZANO, Y. ARENAS, S. DADSETAN, J. FORTEZA, S. GIL-PEROTIN, L. CUBAS-NUNEZ, B. CASANOVA, F. GRACIA, N. VARELA-ANDRES, C. MONTOLIU, M. LLANSOLA and V. FELIPO

Journal of Neuroinflammation 2020 Feb, DOI: 10.1186/s12974-020-01746-z, Vol. 17, pag. 70-70

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Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy

C. SAN MARTIN-VALENZUELA, A. BORRAS-BARRACHINA, J. GALLEGO, A. URIOS, V. MESTRE-SALVADOR, P. CORREA-GHISAYS, M. BALLESTER, D. ESCUDERO-GARCIA, J. TOSCA, C. MONTON, M. RIOS, E. KOSENKO, V. FELIPO, R. TABARES-SEISDEDOS, G. SELVA-VERA and C. MONTOLIU

Journal of Clinical Medicine 2020 Jul, DOI: 10.3390/jcm9072154, Vol. 9, pag.

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Hyperammonemia alters the mismatch negativity in the auditory evoked potential by altering functional connectivity and neurotransmission

R. GARCIA-GARCIA, J. GUERRERO, M. LAVILLA-MIYASATO, J. MAGDALENA, J. ORDONO, M. LLANSOLA, C. MONTOLIU, V. TERUEL-MARTI and V. FELIPO

JOURNAL OF NEUROCHEMISTRY 2020 Jul, DOI: 10.1111/jnc.14941, Vol. 154, pag. 56-70

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Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats

P. IZQUIERDO-ALTAREJOS, A. CABRERA-PASTOR, H. GONZALEZ-KING, C. MONTOLIU and V. FELIPO

Cells 2020 Mar, DOI: 10.3390/cells9030572, Vol. 9, pag.

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The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence.

Kosenko E, Tikhonova L, Alilova G, Urios A and Montoliu C