THE NEURONAL AND TISSUE REGENERATION LAB (NTRL), ESTABLISHED IN 2010 AT THE CIPF, HAS BEEN AT THE FOREFRONT OF SPINAL CORD INJURY (SCI) RESEARCH—A FIELD THAT REMAINS A MAJOR UNMET CLINICAL CHALLENGE.
Recognizing the complexity and multiphasic nature of SCI, our team has spent the past two decades developing and refining combinatorial strategies for effective cell- and gene-based therapies.
Given the urgent need for innovative approaches beyond conventional treatments, the NTRL is actively pursuing advanced therapeutic strategies aimed at promoting neuroplasticity and enhancing the limited functional recovery typically observed in severe and chronic SCI. Our goal is to translate preclinical findings into realistic opportunities for recovery.
Most recently, the NTRL has been pioneering remote neuromodulation techniques based on on-demand, molecularly guided neuronal activation—used alone or in combination with cell transplantation. These strategies have demonstrated strong potential to enhance neuronal plasticity and improve both motor and sensory functional recovery in rodent models of SCI. Our multidisciplinary toolkit includes optogenetics, conditional genetic manipulation, smart and responsive biomaterials, localized electrical stimulation, and novel neurorehabilitation paradigms—all aligned toward restoring lost neuronal function.
PRESENTATION
GET TO KNOW US BETTER
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CIPF Combination Therapy Based on Cell Therapyand Nanomedicine in Neuronal Regeneration
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CIPF Neuronal and Tissue Regeneration Lab
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Presentation Dr. Victoria Moreno Manzano
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RESEARCH STAFF
THE PEOPLE WHO MAKE IT ALL POSSIBLE
Victoria Moreno Manzano
vmorenom@cipf.es
Guillem Paniagua Soriano
gpaniagua@cipf.es
Eric López Mocholi
elopezm@cipf.es
Samuel Martín Pérez
smartin@cipf.es
Ana Isabel Fraga Sánchez
aifraga@cipf.es
PUBLICATIONS
OUR SCIENTIFIC CONTRIBUTIONS
Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury.
Nature Communications 2022 May, DOI: 10.1038/s41467-022-30467-5, Vol. 13, pag. 2933-2933
NPC transplantation rescues sci-driven cAMP/EPAC2 alterations, leading to neuroprotection and microglial modulation
CELLULAR AND MOLECULAR LIFE SCIENCES 2022 Aug, DOI: 10.1007/s00018-022-04494-w, Vol. 79, pag. 455-455
