OUR RESEARCH PROGRAM EXPLORES THE MOLECULAR MECHANISMS INVOLVED IN CONTROLLING ENERGY EXPENDITURE, FAT DEPOSITION AND THE MECHANISMS CONTROLLING THE PARTITION OF ENERGY TOWARDS OXIDATION OR STORAGE. ARE INTERESTED IN THE FOLLOWING INTERRELATED QUESTIONS:
- How the expansion of adipose tissue relates to the development of the Metabolic Syndrome?
- How lipotoxicity and/or changes in adipokines secreted by adipose tissue affect insulin sensitivity in skeletal muscle, heart, liver, brain, beta cells and macrophages?
- Whether modifications in adipogenesis and remodeling of adipose tissue may be good strategies to ameliorate the metabolic effects of obesity?
- Elucidation of the molecular mechanisms that control energy expenditure and brown fat activation.
- Investigating how mechanisms modulating the partitioning of nutrients towards fatty acid oxidation in skeletal muscle and away from storage in adipose tissue may prevent the devastating metabolic effects of obesity.
To address these challenges is a daunting task that requires the modulation of highly integrated and complex mechanisms of energy homeostasis designed to energy balance. According to this integrated concept of energy homeostasis, our laboratory uses an Integrated Physiology approach that relies significantly upon the generation and detailed in vivo phenotyping of genetically modified organisms. Following a Systems Biology approach, we integrate transcriptomic and lipidomic analysis using bioinformatics to identify organ-specific lipid metabolic networks relevant to insulin resistance and metabolic disease.
PRESENTATION
GET TO KNOW US BETTER
RESEARCH STAFF
THE PEOPLE WHO MAKE IT ALL POSSIBLE
Antonio Vidal Puig
avidal-puig@cipf.es
Magdalena Villarroya Grau
mvillarroya@cipf.es
Maria Luque Tévar
mluque@cipf.es
Vivien Chavanelle
vchavanelle@cipf.es
Ana López Rodríguez
alopezr@cipf.es
PUBLICATIONS
OUR SCIENTIFIC CONTRIBUTIONS
SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation.
Nature Metabolism 2021 Sep, DOI: 10.1038/s42255-021-00440-5, Vol. 3, pag. 1150-1162
Allostatic hypermetabolic response in PGC1a/ß heterozygote mouse despite mitochondrial defects.
FASEB JOURNAL 2021 Sep, DOI: 10.1096/fj.202100262RR, Vol. 35, pag.
Unraveling the Developmental Roadmap toward Human Brown Adipose Tissue
Stem Cell Reports 2021 Mar, DOI: 10.1016/j.stemcr.2021.01.013, Vol. 16, pag. 641-655
