We study microbiome functions and their regulation to understand interactions with the host in health and disease.
The goal of our group is to understand which functions are being performed by the microorganisms in the gut microbiota and how they are regulated, to rationally develop targeted strategies to modulate the activity of our inner microbes.
Microorganisms, and in particular, bacteria, have a large functional plasticity to adapt to changes in their environment and survive. However, this functional plasticity is poorly understood in the context of complex ecosystems such as the gut microbiota. Our group will study what is the natural transcriptional variation in human gut bacteria, which host-related factors (such as diet or different diseases) alter this gene expression and what are the regulatory mechanisms underlying these changes. We will then harness this knowledge to develop novel strategies to modulate the activity of the gut microbiota in disorders where this functionality is altered.
To achieve our goals, we will use a Systems Biology approach that combines experimental work, using in vitro and in vivo models of the gut microbial communities, with multiomic profiling and computational data analysis and integration.
PRESENTATION
GET TO KNOW US BETTER
RESEARCH STAFF
THE PEOPLE WHO MAKE IT ALL POSSIBLE
Verónica Llorens Rico
vllorens@cipf.es
Tania Gaviria Cantin
tgaviria@cipf.es
Cristina Marti Ibáñez
mcmarti@cipf.es
Francisco Merino Casallo
fmerino@cipf.es
Laura Sanchez Salom
lsanchezs@cipf.es
Ana Rosa Marquez Blesa
armarquez@cipf.es
PUBLICATIONS
OUR SCIENTIFIC CONTRIBUTIONS
Bacteria in metastatic sites: Unveiling hidden players in cancer progression.
CANCER CELL 2024 Jul, DOI: 10.1016/j.ccell.2024.05.022, Vol. 42, pag. 1142-1146
Microbiome confounders and quantitative profiling challenge predicted microbial targets in colorectal cancer development.
NATURE MEDICINE 2024 May, DOI: 10.1038/s41591-024-02963-2, Vol. 30, pag. 1339-1348
Single-cell approaches in human microbiome research.
CELL 2022 Jul, DOI: 10.1016/j.cell.2022.06.040, Vol. 185, pag. 2725-2738
