THE LABORATORY OF PATHOPHYSIOLOGY AND THERAPIES FOR VISION DISEASES, PART OF THE JOINT RESEARCH UNIT ON RARE DISEASES CIPF-IIS La Fe and a member of CIBERER, focuses on the development of neuroprotective pharmacological therapies for degenerative retinal diseases such as retinitis pigmentosa and diabetic retinopathy.
It employs cellular and animal models to study the mechanisms of neurodegeneration and to advance therapeutic strategies with clinical potential. The lab has translated part of its research into patient-oriented studies, including NUTRARET and the ADARET clinical trial.
Its research lines include anti-inflammatory therapies, antioxidants, and bioactive lipids derived from omega-3. In recent years, the lab has incorporated the use of both polymeric and lipid-based nanocarriers, in collaboration with specialized groups in nanotechnology.
It is equipped with tools to assess visual function in vivo, such as electroretinography (ERG), fundus imaging, and behavioral tests. The group actively collaborates with hospitals such as La Fe, Clínico, and Manises, as well as with patient associations, particularly RETINA CV, to ensure clinical translation of its findings. In addition, the lab maintains a strong commitment to scientific outreach and public engagement. Its projects are funded by the Instituto de Salud Carlos III (ISCIII), Fundación ONCE, Generalitat Valenciana, among others.
PRESENTATION
GET TO KNOW US BETTER
RESEARCH STAFF
THE PEOPLE WHO MAKE IT ALL POSSIBLE
Regina Rodrigo Nicolás
rrodrigo@cipf.es
M Carmen Castro Quero
mcastro@cipf.es
Isabel Campillo Nuevo
icampillo@cipf.es
PUBLICATIONS
OUR SCIENTIFIC CONTRIBUTIONS
Noninvasive ocular delivery of adalimumab-loaded nanostructured lipid carriers for targeted retinitis pigmentosa therapy.
BIOMEDICINE & PHARMACOTHERAPY 2025 Apr, DOI: 10.1016/j.biopha.2025.117962, Vol. 185, pag. 117962-117962
An SPM-Enriched Marine Oil Supplement Shifted Microglia Polarization toward M2, Ameliorating Retinal Degeneration in rd10 Mice.
Antioxidants 2022 Dec, DOI: 10.3390/antiox12010098, Vol. 12, pag.
NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial
Frontiers in Nutrition 2022 Mar, DOI: 10.3389/fnut.2022.847910, Vol. 9, pag. 847910-847910
