We work in the field of Regenerative Medicine, looking for efficient cellular therapies, with a focus on the functional rescue of neuronal activity after spinal cord injury.

In the Neuronal and Tissue Regeneration Laboratory (LRTN, in its Spanish acronym) our work is focused on the search for efficient cell therapies and adapting them to treat an increasing range of pathological processes. We also aim to translate these different treatment modalities from experimental models into clinical settings.

Our group’s primary line of research is the functional rescue of the neuronal activity lost after a spinal cord injury (SCI). SCIs are very complex and involve multiphasic processes. This has led us to prospectively design alternative cell-based treatments that combine pharmacological supplements, tissue engineering and biomaterials, electrical-magnetic stimulation, neuronal interfaces, and neurorehabilitation approaches, with the ultimate objective of favoring neuroplasticity and producing functional results.

At the preclinical level, our overriding goal is the efficient translation of the therapies we are developing into clinical practice. Proof of this vision is the creation of the FactorStem spin-off biotechnological company (www.factorstem.es), whose objective is the development and application of cell therapies in veterinary medicine. We are also working closely with different reference hospitals for translational research (Hospital La Fe and Hospital Casa de la Salud in Valencia, and Hospital Vall de Hebron in Barcelona) to further our aim of achieving bench to bedside medicine.

Presentation

Get to know us better

Research Staff

The people who make it all possible

M Victoria Moreno Manzano
vmorenom@cipf.es

Esther Giraldo Reboloso
egiraldo@cipf.es

Belén Mollá Moliner
bmolla@cipf.es

Ana Alastrue Agudo
aalastrue@cipf.es

Eric López Mocholi
elopezm@cipf.es

Pablo Bonilla Villamil
pbonilla@cipf.es

Beatriz Martinez Rojas
bmartinez@cipf.es

Sonia Prakash Lalwani 
splalwani@cipf.es

Maria Del Mar Sánchez Martín
mmsanchez@cipf.es

Maria De Les Neus Torres Hernández
ntorres@cipf.es

Publications

Our scientific contributions

FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury
A. ALASTRUE-AGUDO, F. RODRIGUEZ-JIMENEZ, E. MOCHOLI, F. DE GIORGIO, S. ERCEG and V. MORENO-MANZANO
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018 Jan,  DOI:  10.3390/ijms19010200,  Vol. 19,  pag. 200

Combined polymer-curcumin conjugate and ependymal progenitor/stem cell treatment enhances spinal cord injury functional recovery
R. REQUEJO-AGUILAR, A. ALASTRUE-AGUDO, M. CASES-VILLAR, E. LOPEZ-MOCHOLI, R. ENGLAND, M. VICENT and V. MORENO-MANZANO
BIOMATERIALS, 2017 Jan,  DOI:  10.1016/j.biomaterials.2016.10.032,  Vol. 113,  pag. 18-30

Human Suprapatellar Fat Pad-Derived Mesenchymal Stem Cells Induce Chondrogenesis and Cartilage Repair in a Model of Severe Osteoarthritis
I. MUNOZ-CRIADO, J. MESEGUER-RIPOLLES, M. MELLADO-LOPEZ, A. ALASTRUE-AGUDO, R. GRIFFETH, J. FORTEZA-VILA, R. CUGAT, M. GARCIA and V. MORENO-MANZANO
Stem Cells International, 2017 Jan,  DOI:  10.1155/2017/4758930,  Vol. 2017,  pag. 4758930-4758930

Methacrylate-endcapped caprolactone and FM19G11 provide a proper niche for spinal cord-derived neural cells
T. VALDES-SANCHEZ, F. RODRIGUEZ-JIMENEZ, D. GARCIA-CRUZ, J. ESCOBAR-IVIRICO, A. ALASTRUE-AGUDO, S. ERCEG, M. MONLEON and V. MORENO-MANZANO
Journal of Tissue Engineering and Regenerative Medicine, 2015 Jun,  DOI:  10.1002/term.1735,  Vol. 9,  pag. 734-739

Purinergic Receptors in Spinal Cord-Derived Ependymal Stem/Progenitor Cells and Their Potential Role in Cell-Based Therapy for Spinal Cord Injury
R. GOMEZ-VILLAFUERTES, F. RODRIGUEZ-JIMENEZ, A. ALASTRUE-AGUDO, M. STOJKOVIC, M. MIRAS-PORTUGAL and V. MORENO-MANZANO
CELL TRANSPLANTATION, 2015 Jan,  DOI:  10.3727/096368914X682828,  Vol. 24,  pag. 1493-1509

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