SEMINAR: Marko Miler

Speaker: Marko Miller
Department of Cytology, Institute for Biological Research “Siniša Stanković“-National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia

Geroprotective Effects of Citrus Flavanones on Hepatic Redox Regulation: Modulation of Antioxidant Defense, H₂S Signaling, and Protein Persulfidation in Naturally Aged Rats

Sinopsis: As we age, our antioxidant defenses weaken, redox signaling becomes dysregulated, and protective modifications like protein persulfidation decline—especially in metabolically active organs like the liver. This redox imbalance contributes to increased cellular stress, metabolic dysfunction, and age-related disease.

In this talk, I’ll present data from our study using naturally aged Wistar rats to explore how citrus flavanones—naringenin, hesperetin, and eriocitrin—can act as geroprotective agents by restoring redox homeostasis in the liver. We focused on three interconnected mechanisms: classic antioxidant enzyme defense, hydrogen sulfide (H₂S) signaling, and protein persulfidation, a key posttranslational modification that protects cysteine residues from irreversible oxidation.

This presentation will highlight how simple dietary components can influence complex systemic redox processes, and why persulfidation deserves more attention in aging and geroprotection research.