


13feb12:0013:00Xavier TrepatBottom-up mechanobiology: from cell sheets to organoids
Event Details
BOTTOM-UP MECHANOBIOLOGY: FROM CELL SHEETS TO ORGANOIDS Xavier Trepat, ICREA Institute for Bioengineering of Catalonia, Barcelona, Spain February 13 – 12:00h Salón Forteza, CIPF Abstract: Epithelial sheets form specialized 3D structures
Event Details
BOTTOM-UP MECHANOBIOLOGY: FROM CELL SHEETS TO ORGANOIDS
Xavier Trepat, ICREA Institute for Bioengineering of Catalonia, Barcelona, Spain
February 13 – 12:00h
Salón Forteza, CIPF
Abstract: Epithelial sheets form specialized 3D structures suited to their physiological roles, such as branched alveoli in the lungs, tubes in the kidney, and villi in the intestine. To generate and maintain these structures, epithelia must undergo complex 3D deformations across length and time scales. How epithelial shape arises from active stresses, viscoelasticity and luminal pressure remains poorly understood. I will present different approaches to study the mechanobiology of epithelial shape from the bottom up. I will discuss new technologies to design epithelia of arbitrary size and geometry and to subject them to controlled mechanical deformations in 3D. I will show that monolayers exhibit superelastic behavior when stretch is applied and that they readily buckle when compressed. We use this phenomenology and a 3D vertex model to rationally direct spontaneous pattern formation, and hence engineer tissue folding. I will also present our recent advances to understand the mechanobiology of intestinal organoids. We show that these organoids exhibit a non-monotonic stress distribution that defines mechanical and functional compartments. Finally, I will discuss how intestinal mechanobiology is derailed in patient-derived colorectal cancer organoids.
Time
13.02.2025 12:00 – 13:00(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Why do some individuals live longer? Mapping and controlling the stochastic dynamics of aging systems. Nicholas Stroustrup, Centre for Genomic Regulation & the Barcelona Collaboratorium for Modelling and Predictive Biology March 10
Event Details
Why do some individuals live longer? Mapping and controlling the stochastic dynamics of aging systems.
Nicholas Stroustrup, Centre for Genomic Regulation & the Barcelona Collaboratorium for Modelling and Predictive Biology
March 10 – 12:00h
Salón Forteza, CIPF
Abstract:
Time
10.03.2025 12:00 – 13:00(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Time
31.03.2025 19:30 – 20:30(GMT+01:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain