How to engineer human pluripotent stem cells to understand human development and disease.

Speaker: Núria Montserrat
Institution: PhD, ICREA Research Professor at the Institute for Bioengineering of Catalonia. Barcelona, Spain.
Place: Jerónimo Forteza conference room, CIPF

Abstract:

In recent years considerable progress has been made in the development of faithful procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step in this direction has also been the derivation of three-dimensional cell cultures that represent micrometer to centimeter size versions of human organs, the so-called organoids.

Here we will discuss current developments in the hPSCs-organoid field and emphasize the achievements and ongoing challenges of bringing together hPSC organoid differentiation, bioengineering and disease modelling with a particular focus on genetic and systemic disorders compromising kidney and heart. We will further discuss on how the convergence of stem cell biology and bioengineering now offers the possibility to provide physiologically relevant stimuli in a controlled fashion in these model systems resulting in the development of naturally inspired approaches to overcome major limitations of the organoid field.

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