may, 2022

20may12:0013:00SEMINAR: Stefania Carobbio / Diego Leiva12:00 - 13:00 Event Type :SEMINAR

Event Details

12:00 – 12:30 Stefania Carobbio

Obesity, Diabetes and Comorbidities: A stem cell based approach.

My talk will focus on my current research program at the CIPF on white adipose tissue expansion and brown adipose tissue thermogenesis using a human stem cell approach.

 

12:30 – 13:00 Diego Leiva

Targeting MCL1-BOK TMD interaction as a novel strategy to induce cell death in tumours

Induced myeloid leukemia cell differentiation protein (MCL1) is an anti-apoptotic member of the B cell Lymphoma-2 (BCL2) family of proteins, overexpressed in different tumours. Its overexpression is associated with poor prognosis and resistance to therapies. MCL1 inhibitors, currently in clinical trials, target the cytosolic Bcl-2 homology 3 (BH3) domain and induce cell death mediated by apoptotic BAX/BAK executors. However, there are several tumours in which this therapy is not effective, such as those that decrease BAX expression. We have recently discovered that MCL1 interacts with BCL2-related ovarian killer (BOK), another cell death effector member of the BCL2 family, through the transmembrane domain (TMD). In a high throughput screen, we have identified drugs that breaks the transmembrane interaction between MCL1 and BOK (MBoINs), releasing BOK to induce cell death. Our studies demonstrate that MBoINs treatment activates cell death by apoptosis in a BOK dependent and BAX/BAK independent manner. This novel mechanism of action would represent a new therapeutic alternative in oncology.

Time

(Friday) 12:00 - 13:00

Location

Centro de Investigación Príncipe Felipe

Eduardo Primo Yúfera, 3 Valencia Spain

Organizer

Centro de Investigación Príncipe Felipe Eduardo Primo Yúfera, 3

Health Guidelines for this Event

Masks Required
Physical Distance Maintained
Event Area Sanitized