Our goal is to translate the knowledge gained from basic sciences by developing new treatments for patients.
Our group takes several different approaches to try to clarify the molecular and cellular mechanisms involved in inherited retinal diseases such as retinitis pigmentosa (RP). This rare disease is the main genetic cause of blindness in the developed world. We are also study more common disorders affecting the eye and vision.
Like most rare diseases, RP is very heterogeneous, both in terms of its clinical presentation and its genetic features. The genetic defect responsible for RP causes the death of photoreceptors and pigmented epithelium and results in the progressive loss of vision. However, the upregulation of inflammatory mediators such as tumor necrosis factor alpha (TNFα), combined with oxidative stress, can exacerbate neurodegenerative processes in this disease.
Our ultimate goal is to translate the knowledge gained from basic sciences by using it to develop new treatments for patients. To achieve this goal, we focus on searching for new pharmacological approaches to create mutation-independent therapies designed to reduce the deleterious effects of the chronic inflammation and oxidative stress present in these diseases. Thus, we assess novel anti-inflammatory and antioxidant therapies in cell models, retinal explants, and murine models and we are also currently carrying out a study to try to slow down vision loss in patients with RP.
Get to know us better
The people who make it all possible
Regina Rodrigo Nicolás
Isabel Campillo Nuevo
Lorena Olivares González
Our scientific contributions
Intravitreal administration of adalimumab delays retinal degeneration in rd10 mice.
Olivares-González L, Velasco S, Millán JM and Rodrigo R
FASEB JOURNAL, 2020 Oct,  DOI:  10.1096/fj.202000044RR,  Vol. 34,  pag. 13839-13861
HIF-1a stabilization reduces retinal degeneration in a mouse model of retinitis pigmentosa.
Olivares-González L, Martínez-Fernández de la Cámara C, Hervás D, Millán JM and Rodrigo R
FASEB JOURNAL, 2018 May,  DOI:  10.1096/fj.201700985R,  Vol. 32,  pag. 2438-2451
cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants.
Olivares-González L, Martínez-Fernández de la Cámara C, Hervás D, Marín MP, Lahoz A, Millán JM and Rodrigo R
Plos One, 2016 Nov,  DOI:  10.1371/journal.pone.0166717,  Vol. 11,  pag. e0166717
Adalimumab Reduces Photoreceptor Cell Death in A Mouse Model of Retinal Degeneration.
Martínez-Fernández de la Cámara C, Hernández-Pinto AM, Olivares-González L, Cuevas-Martín C, Sánchez-Aragó M, Hervás D, Salom D, Cuezva JM, de la Rosa EJ, Millán JM and Rodrigo R
Scientific Reports, 2015 Jul,  DOI:  10.1038/srep11764,  Vol. 5,  pag. 11764-11764
Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa.
Martínez-Fernández de la Cámara C, Salom D, Sequedo MD, Hervás D, Marín-Lambíes C, Aller E, Jaijo T, Díaz-Llopis M, Millán JM and Rodrigo R
Plos One, 2013 Sep,  DOI:  10.1371/journal.pone.0074223,  Vol. 8,  pag. e74223